Receptor‐Interacting Protein Kinase 3 Deficiency Recruits Myeloid‐Derived Suppressor Cells to Hepatocellular Carcinoma Through the Chemokine (C‐X‐C Motif) Ligand 1–Chemokine (C‐X‐C Motif) Receptor 2 Axis

Yi‐Ming Li, Zhen‐Yu Liu, Jian‐Chao Wang, Jing‐Min Yu, Zhu‐Chun Li, Hai‐Jiao Yang, Juan Tang, Zhi‐Nan Chen – 25 April 2019 – Receptor‐interacting protein kinase 3 (RIP3) is the core regulator that switches cell death from apoptosis to necrosis. However, its role in tumor immunity is unknown. In this study, decreased RIP3 expression was observed in patients with hepatocellular carcinoma (HCC), which correlates with myeloid‐derived suppressor cell (MDSC) accumulation. Moreover, RIP3 is a prognosis factor for patients with HCC.

Reverse Erythroblastosis Virus α Antagonism Promotes Homocysteine Catabolism and Ammonia Clearance

Tianpeng Zhang, Min Chen, Lianxia Guo, Fangjun Yu, Cui Zhou, Haiman Xu, Baojian Wu – 23 April 2019 – Metabolic homeostasis of amino acids is essential for human health. Here, we aimed to investigate a potential role for the clock component reverse erythroblastosis virus α (Rev‐erbα) in circadian regulation of amino acid metabolism. RNA‐seq with Rev‐erbα‐/‐ mice showed expression changes in genes involved in amino acid metabolism, particularly, the urea cycle and methionine metabolism.

The Emerging Role of Nurse Practitioners and Physician Assistants in Liver Transplantation

Amanda J. Chaney, Maria L. Yataco – 23 April 2019 – The evolving role of nurse practitioners (NPs) and physician assistants (PAs) in the United States continues to progress. NP and PA responsibilities have expanded from primary care practices to medical and surgical specialties. They provide acute care in hospitals and intensive care units, and they serve as educators, lobbyists, and researchers. Questions have arisen from NP/PA leaders, physician leaders, and administrators on how to best implement a successful NP/PA model within their practice.

Mannose Phosphate Isomerase and Mannose Regulate Hepatic Stellate Cell Activation and Fibrosis in Zebrafish and Humans

Charles DeRossi, Kathryn Bambino, Joshua Morrison, Isabel Sakarin, Carlos Villacorta‐Martin, Changwen Zhang, Jillian L. Ellis, M. Isabel Fiel, Maria Ybanez, Youngmin A. Lee, Kuan‐lin Huang, Chunyue Yin, Takuya F. Sakaguchi, Scott L. Friedman, Augusto Villanueva, Jaime Chu – 23 April 2019 – The growing burden of liver fibrosis and lack of effective antifibrotic therapies highlight the need for identification of pathways and complementary model systems of hepatic fibrosis.

Platelets and Platelet‐Derived Extracellular Vesicles in Liver Physiology and Disease

Alexandre Balaphas, Jeremy Meyer, Karin Sadoul, Pierre Fontana, Philippe Morel, Carmen Gonelle‐Gispert, Leo H. Bühler – 22 April 2019 – Beyond their role in hemostasis, platelets are proposed as key mediators of several physiological and pathophysiological processes of the liver, such as liver regeneration, toxic or viral acute liver injury, liver fibrosis, and carcinogenesis. The effects of platelets on the liver involve interactions with sinusoidal endothelial cells and the release of platelet‐contained molecules following platelet activation.

Liver Macrophages: Old Dogmas and New Insights

Adrien Guillot, Frank Tacke – 22 April 2019 – Inflammation is a hallmark of virtually all liver diseases, such as liver cancer, fibrosis, nonalcoholic steatohepatitis, alcoholic liver disease, and cholangiopathies. Liver macrophages have been thoroughly studied in human disease and mouse models, unravelling that the hepatic mononuclear phagocyte system is more versatile and complex than previously believed. Liver macrophages mainly consist of liver‐resident phagocytes, or Kupffer cells (KCs), and bone marrow‐derived recruited monocytes.

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