Optimal Biliary Drainage for Patients With Biliary Anastomotic Strictures After Right Lobe Living Donor Liver Transplantation

Min Su You, Woo Hyun Paik, Young Hoon Choi, Bang‐sup Shin, Sang Hyub Lee, Ji Kon Ryu, Yong‐Tae Kim, Kyung‐Suk Suh, Kwang‐Woong Lee, Nam‐Joon Yi, Suk Kyun Hong – 12 April 2019 – Right lobe (RL) living donor liver transplantation (LDLT) usually includes 2 bile duct anastomosis sites, namely, the right anterior and the right posterior segmental ducts. This study aimed to evaluate the optimal treatment for biliary strictures following RL LDLT with respect to unilateral or bilateral drainage techniques.

A Single‐Center Experience on Outcomes of Complementary and Alternative Medicine Use Among Patients With Cirrhosis

Cyriac Abby Philips, Rajaguru Paramaguru, Philip Augustine, Sasidharan Rajesh, Rizwan Ahamed, Tom George, Guruprasad Padsalgi – 12 April 2019 – Drug‐induced liver injury (DILI) due to complementary and alternative medicine (CAM) use is on the rise throughout the world by patients looking for “safer” alternatives. However, data on acute‐on‐chronic liver failure (ACLF) due to CAM are lacking. In a large cohort of patients with cirrhosis, we retrospectively studied CAM‐related health‐seeking behavior and attempted to identify those who developed possible CAM‐DILI‐related ACLF.

Hepatology Highlights

Hirsh D. Trivedi, Daryl T.Y. Lau, Tasha B. Kulai, Harmeet Malhi, Robert E. Schwartz, Joseph F. Pisa, Robert S. Brown, Nicholas Russo, Kavitha M. Nair, Giorgio Roccaro, Petra Hirsova, Vikas Gupta, Xu Xu, Tibor Krisko, Enis Kostallari – 12 April 2019

Hepatology Highlights

Hirsh D. Trivedi, Daryl T.Y. Lau, Tasha B. Kulai, Harmeet Malhi, Robert E. Schwartz, Joseph F. Pisa, Robert S. Brown, Nicholas Russo, Kavitha M. Nair, Giorgio Roccaro, Petra Hirsova, Vikas Gupta, Xu Xu, Tibor Krisko, Enis Kostallari – 12 April 2019

Causes of hOCT1‐Dependent Cholangiocarcinoma Resistance to Sorafenib and Sensitization by Tumor‐Selective Gene Therapy

Elisa Lozano, Rocio I.R. Macias, Maria J. Monte, Maitane Asensio, Sofia Carmen, Laura Sanchez‐Vicente, Marta Alonso‐Peña, Ruba Al‐Abdulla, Patricia Munoz‐Garrido, Letizia Satriano, Colm J. O'Rourke, Jesus M. Banales, Matias A. Avila, Maria L. Martinez‐Chantar, Jesper B. Andersen, Oscar Briz, Jose J.G. Marin – 10 April 2019 – Although the multi‐tyrosine kinase inhibitor sorafenib is useful in the treatment of several cancers, cholangiocarcinoma (CCA) is refractory to this drug.

Hyperglycemia‐Triggered Sphingosine‐1‐Phosphate and Sphingosine‐1‐Phosphate Receptor 3 Signaling Worsens Liver Ischemia/Reperfusion Injury by Regulating M1/M2 Polarization

Yuanchang Hu, Chao Yang, Gefengqiang Shen, Shikun Yang, Xuyu Cheng, Feng Cheng, Jianhua Rao, Xuehao Wang – 10 April 2019 – Hyperglycemia aggravates hepatic ischemia/reperfusion injury (IRI), but the underlying mechanism for the aggravation remains elusive. Sphingosine‐1‐phosphate (S1P) and sphingosine‐1‐phosphate receptors (S1PRs) have been implicated in metabolic and inflammatory diseases. Here, we discuss whether and how S1P/S1PRs are involved in hyperglycemia‐related liver IRI.

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