Seeing Both the Forest and the Trees: Where Does 3‐Dimensional Printing Fit in Pediatric Living Donor Liver Transplantation?
George V. Mazariegos, Abhinav Humar – 25 April 2019
Robotic Liver Resection Expands the Opportunities of Bridging Before Liver Transplantation
Paolo Magistri, Tiziana Olivieri, Giacomo Assirati, Gian Piero Guerrini, Roberto Ballarin, Giuseppe Tarantino, Fabrizio Benedetto – 25 April 2019
The Effect of Immunosuppression on Coagulation After Liver Transplantation
Sotiria Bedreli, Katja Straub, Anne Achterfeld, Katharina Willuweit, Antonios Katsounas, Fuat Saner, Heiner Wedemeyer, Kerstin Herzer – 25 April 2019 – Everolimus (EVR) is a mammalian target of rapamycin (mTOR) inhibitor commonly used for immunosuppression (IS) after liver transplantation (LT). However, there are concerns about whether mTOR inhibitors may move the hemostatic balance toward a higher likelihood of thrombosis. The present study aimed to investigate potential coagulation disorders after the administration of EVR.
Metabolic Indications for Pediatric Liver Transplantation: A Slow Train Coming
Nedim Hadžić – 25 April 2019
Receptor‐Interacting Protein Kinase 3 Deficiency Recruits Myeloid‐Derived Suppressor Cells to Hepatocellular Carcinoma Through the Chemokine (C‐X‐C Motif) Ligand 1–Chemokine (C‐X‐C Motif) Receptor 2 Axis
Yi‐Ming Li, Zhen‐Yu Liu, Jian‐Chao Wang, Jing‐Min Yu, Zhu‐Chun Li, Hai‐Jiao Yang, Juan Tang, Zhi‐Nan Chen – 25 April 2019 – Receptor‐interacting protein kinase 3 (RIP3) is the core regulator that switches cell death from apoptosis to necrosis. However, its role in tumor immunity is unknown. In this study, decreased RIP3 expression was observed in patients with hepatocellular carcinoma (HCC), which correlates with myeloid‐derived suppressor cell (MDSC) accumulation. Moreover, RIP3 is a prognosis factor for patients with HCC.
The Emerging Role of Nurse Practitioners and Physician Assistants in Liver Transplantation
Amanda J. Chaney, Maria L. Yataco – 23 April 2019 – The evolving role of nurse practitioners (NPs) and physician assistants (PAs) in the United States continues to progress. NP and PA responsibilities have expanded from primary care practices to medical and surgical specialties. They provide acute care in hospitals and intensive care units, and they serve as educators, lobbyists, and researchers. Questions have arisen from NP/PA leaders, physician leaders, and administrators on how to best implement a successful NP/PA model within their practice.
The Gut‐Liver Axis in Primary Sclerosing Cholangitis: Are Pathobionts the Missing Link?
Steven P. O’Hara, Nicholas F. LaRusso – 23 April 2019
Reverse Erythroblastosis Virus α Antagonism Promotes Homocysteine Catabolism and Ammonia Clearance
Tianpeng Zhang, Min Chen, Lianxia Guo, Fangjun Yu, Cui Zhou, Haiman Xu, Baojian Wu – 23 April 2019 – Metabolic homeostasis of amino acids is essential for human health. Here, we aimed to investigate a potential role for the clock component reverse erythroblastosis virus α (Rev‐erbα) in circadian regulation of amino acid metabolism. RNA‐seq with Rev‐erbα‐/‐ mice showed expression changes in genes involved in amino acid metabolism, particularly, the urea cycle and methionine metabolism.
MRI Assessment of Treatment Response in HIV‐associated NAFLD: A Randomized Trial of a Stearoyl‐Coenzyme‐A‐Desaturase‐1 Inhibitor (ARRIVE Trial)
Veeral H. Ajmera, Edward Cachay, Christian Ramers, Irine Vodkin, Shirin Bassirian, Seema Singh, Neeraj Mangla, Richele Bettencourt, Jeannette L.
Mannose Phosphate Isomerase and Mannose Regulate Hepatic Stellate Cell Activation and Fibrosis in Zebrafish and Humans
Charles DeRossi, Kathryn Bambino, Joshua Morrison, Isabel Sakarin, Carlos Villacorta‐Martin, Changwen Zhang, Jillian L. Ellis, M. Isabel Fiel, Maria Ybanez, Youngmin A. Lee, Kuan‐lin Huang, Chunyue Yin, Takuya F. Sakaguchi, Scott L. Friedman, Augusto Villanueva, Jaime Chu – 23 April 2019 – The growing burden of liver fibrosis and lack of effective antifibrotic therapies highlight the need for identification of pathways and complementary model systems of hepatic fibrosis.