Rehabilitation of Discarded Steatotic Livers Using Ex Situ Normothermic Machine Perfusion: A Future Source of Livers for Transplantation
Siavash Raigani, James F. Markmann, Heidi Yeh – 11 May 2019
Necroptotic Cell Death in Liver Transplantation and Underlying Diseases: Mechanisms and Clinical Perspective
Shaojun Shi, Monique M. A. Verstegen, Laura Mezzanotte, Jeroen Jonge, Clemens W. G. M. Löwik, Luc J. W. Laan – 11 May 2019 – Cell death is a natural process for the turnover of aged cells, but it can also arise as a result of pathological conditions. Cell death is recognized as a key feature in both acute and chronic hepatobiliary diseases caused by drug, alcohol, and fat uptake; by viral infection; or after surgical intervention. In the case of chronic disease, cell death can lead to (chronic) secondary inflammation, cirrhosis, and the progression to liver cancer.
Methionine Adenosyltransferase α1 Is Targeted to the Mitochondrial Matrix and Interacts with Cytochrome P450 2E1 to Lower Its Expression
Ben Murray, Hui Peng, Lucia Barbier‐Torres, Aaron E. Robinson, Tony W. H. Li, Wei Fan, Maria Lauda Tomasi, Roberta A. Gottlieb, Jenny Van Eyk, Zhimin Lu, Maria L. Martínez‐Chantar, Suthat Liangpunsakul, Nicholas J. Skill, José M. Mato, Shelly C. Lu – 11 May 2019 – Methionine adenosyltransferase α1 (MATα1, encoded by MAT1A) is responsible for hepatic biosynthesis of S‐adenosyl methionine, the principal methyl donor. MATα1 also act as a transcriptional cofactor by interacting and influencing the activity of several transcription factors.
Dependency of Cholangiocarcinoma on Cyclin D–Dependent Kinase Activity
Gunya Sittithumcharee, Orawan Suppramote, Kulthida Vaeteewoottacharn, Chumphon Sirisuksakun, Supawan Jamnongsong, Phatthamon Laphanuwat, Monthira Suntiparpluacha, Arriya Matha, Porncheera Chusorn, Pongsakorn Buraphat, Chumpot Kakanaporn, Komgrid Charngkaew, Atit Silsirivanit, Krittiya Korphaisarn, Somchai Limsrichamrern, Pinpat Tripatara, Chawalit Pairojkul, Sopit Wongkham, Somponnat Sampattavanich, Seiji Okada, Siwanon Jirawatnotai – 11 May 2019 – Cholangiocarcinoma (CCA) is a bile duct cancer with a very poor prognosis.
Integrated Omics Reveals Tollip as an Regulator and Therapeutic Target for Hepatic Ischemia‐Reperfusion Injury in Mice
Zhen‐Zhen Yan, Yong‐Ping Huang, Xin Wang, Hai‐Ping Wang, Fei Ren, Rui‐Feng Tian, Xu Cheng, Jie Cai, Yan Zhang, Xue‐Yong Zhu, Zhi‐Gang She, Xiao‐Jing Zhang, Zan Huang, Hongliang Li – 11 May 2019 – Hepatic ischemia‐reperfusion (IR) injury is the leading cause of liver dysfunction and failure after liver resection or transplantation and lacks effective therapeutic strategies. Here, we applied a systematic proteomic analysis to identify the prominent contributors to IR‐induced liver damage and promising therapeutic targets for this condition.
Fibrosing Cholestatic Hepatitis–Like Syndrome in an Immunocompetent Patient With an Acute Flare of Chronic Hepatitis B
Nigel Sutherland, Christopher Foong Dhin Li Wai Suen, Christopher Mills, Julie Lokan, Marie Sinclair – 11 May 2019
Fibrosing Cholestatic Hepatitis–Like Syndrome in an Immunocompetent Patient With an Acute Flare of Chronic Hepatitis B
Nigel Sutherland, Christopher Foong Dhin Li Wai Suen, Christopher Mills, Julie Lokan, Marie Sinclair – 11 May 2019
Deficient IL‐6/Stat3 Signaling, High TLR7, and Type I Interferons in Early Human Alcoholic Liver Disease: A Triad for Liver Damage and Fibrosis
Peter Stärkel, Bernd Schnabl, Sophie Leclercq, Mina Komuta, Ramon Bataller, Josepmaria Argemi, Elena Palma, Shilpa Chokshi, Claus Hellerbrand, Luca Maccioni, Nicolas Lanthier, Isabelle Leclercq – 10 May 2019 – Mechanisms underlying alcohol‐induced liver injury and its progression still remain incompletely understood. Animal models can only address some aspects of the pathophysiology that requires studies directly in humans, which are scarce.
Deficient IL‐6/Stat3 Signaling, High TLR7, and Type I Interferons in Early Human Alcoholic Liver Disease: A Triad for Liver Damage and Fibrosis
Peter Stärkel, Bernd Schnabl, Sophie Leclercq, Mina Komuta, Ramon Bataller, Josepmaria Argemi, Elena Palma, Shilpa Chokshi, Claus Hellerbrand, Luca Maccioni, Nicolas Lanthier, Isabelle Leclercq – 10 May 2019 – Mechanisms underlying alcohol‐induced liver injury and its progression still remain incompletely understood. Animal models can only address some aspects of the pathophysiology that requires studies directly in humans, which are scarce.
LiverLearning®: 2019 Webinar: Management of NAFLD: Integrating Strategies from Obesity Medicine into Clinical Practice
NAFLD is an increasing public health crisis. Although there are no FDA approved medications for the treatment of NAFLD, it is well established that weight loss can improve the metabolic and histologic parameters associated with NAFLD. This webinar will identify key lifestyle changes, pharmacotherapy, and the role of bariatric surgery in obesity management in patients with NAFLD.