CD8+ T Cells Promote Maturation of Liver‐Resident NK Cells Through the CD70‐CD27 axis

Lu Bai, Hui Peng, Xiaolei Hao, Ling Tang, Cheng Sun, Meijuan Zheng, Fubao Liu, Zhexiong Lian, Li Bai, Haiming Wei, Rui Sun, Zhigang Tian – 11 May 2019 – Liver‐resident natural killer (LrNK) cells are a unique subset of NK cells that are distinct from conventional NK cells. However, little is known about the mechanisms by which LrNK cells mature. In this study, we discovered that LrNK cells exhibit a relatively immature phenotype and impaired cytotoxic capacity in the absence of CD8+ T cells.

Necroptotic Cell Death in Liver Transplantation and Underlying Diseases: Mechanisms and Clinical Perspective

Shaojun Shi, Monique M. A. Verstegen, Laura Mezzanotte, Jeroen Jonge, Clemens W. G. M. Löwik, Luc J. W. Laan – 11 May 2019 – Cell death is a natural process for the turnover of aged cells, but it can also arise as a result of pathological conditions. Cell death is recognized as a key feature in both acute and chronic hepatobiliary diseases caused by drug, alcohol, and fat uptake; by viral infection; or after surgical intervention. In the case of chronic disease, cell death can lead to (chronic) secondary inflammation, cirrhosis, and the progression to liver cancer.

Methionine Adenosyltransferase α1 Is Targeted to the Mitochondrial Matrix and Interacts with Cytochrome P450 2E1 to Lower Its Expression

Ben Murray, Hui Peng, Lucia Barbier‐Torres, Aaron E. Robinson, Tony W. H. Li, Wei Fan, Maria Lauda Tomasi, Roberta A. Gottlieb, Jenny Van Eyk, Zhimin Lu, Maria L. Martínez‐Chantar, Suthat Liangpunsakul, Nicholas J. Skill, José M. Mato, Shelly C. Lu – 11 May 2019 – Methionine adenosyltransferase α1 (MATα1, encoded by MAT1A) is responsible for hepatic biosynthesis of S‐adenosyl methionine, the principal methyl donor. MATα1 also act as a transcriptional cofactor by interacting and influencing the activity of several transcription factors.

Dependency of Cholangiocarcinoma on Cyclin D–Dependent Kinase Activity

Gunya Sittithumcharee, Orawan Suppramote, Kulthida Vaeteewoottacharn, Chumphon Sirisuksakun, Supawan Jamnongsong, Phatthamon Laphanuwat, Monthira Suntiparpluacha, Arriya Matha, Porncheera Chusorn, Pongsakorn Buraphat, Chumpot Kakanaporn, Komgrid Charngkaew, Atit Silsirivanit, Krittiya Korphaisarn, Somchai Limsrichamrern, Pinpat Tripatara, Chawalit Pairojkul, Sopit Wongkham, Somponnat Sampattavanich, Seiji Okada, Siwanon Jirawatnotai – 11 May 2019 – Cholangiocarcinoma (CCA) is a bile duct cancer with a very poor prognosis.

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