Baseline Level of Hepatitis B Core Antibody Predicts Spontaneous Hepatitis B e Antigen (HBeAg) Seroconversion in HBeAg‐Positive Children With a Normal Alanine Aminotransferase Level

Ho‐Sheng Chen, Jia‐Feng Wu, Tung‐Hung Su, Huey‐Ling Chen, Hong‐Yuan Hsu, Ning‐Shao Xia, Pei‐Jer Chen, Mei‐Hwei Chang – 23 May 2019 – It is not clear whether baseline hepatitis B core antibody (anti‐HBc) level in hepatitis B e antigen (HBeAg)‐positive children with a normal alanine aminotransferase (ALT) level is predictive of spontaneous HBeAg seroconversion.

Biliary Obstruction Promotes Multilineage Differentiation of Hepatic Stem Cells

Mladen I. Yovchev, Edward J. Lee, Waldemar Rodriguez‐Silva, Joseph Locker, Michael Oertel – 23 May 2019 – Because of their high regenerative potential, stem cells are an ideal resource for development of therapies that replace injured tissue mass and restore function in patients with end‐stage liver diseases. Using a rat model of bile duct ligation (BDL) and biliary fibrosis, we investigated cell engraftment, liver repopulation, and ectopic tissue formation after intrasplenic transplantation of epithelial stem/progenitor cells.

The Novel N,N‐bis‐2‐Hydroxyethyl‐2‐Aminoethanesulfonic Acid–Gluconate–Polyethylene Glycol–Hypothermic Machine Perfusion Solution Improves Static Cold Storage and Reduces Ischemia/Reperfusion Injury in Rat Liver Transplant

Matías E. Carnevale, Natalia Lausada, Leonardo Juan de Paz, Pablo Stringa, Mariana Machuca, Martin Rumbo, Edgardo E. Guibert, Claudio Tiribelli, Gabriel E. Gondolesi, Joaquin V. Rodriguez – 23 May 2019 – Organ transplantation is the treatment of choice against terminal and irreversible organ failure. Optimal preservation of the graft is crucial to counteract cold ischemia effects.

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Benedikt Schaefer, Armin Finkenstedt, Maria Effenberger, André Viveiros, Herbert Tilg, Heinz Zoller – 23 May 2019

Improved Survival Following Living Donor Liver Transplantation for Pediatric Acute Liver Failure: Analysis of 20 Years of US National Registry Data

Daniel J. Firl, Kazunari Sasaki, John McVey, Vera Hupertz, Kadakkal Radhakrishnan, Masato Fujiki, Bijan Eghtesad, Charles M. Miller, Cristiano Quintini, Koji Hashimoto – 22 May 2019 – This study estimated the utility of technical variant grafts (TVGs), such as split/reduced liver transplantation (SRLT) and living donor liver transplantation (LDLT), in pediatric acute liver failure (PALF). PALF is a devastating condition portending a poor prognosis without liver transplantation (LT).

Impact of a Prohibitive Versus Restrictive Tobacco Policy on Liver Transplant Candidate Outcomes

Alisa Likhitsup, Ammar Hassan, Jessica Mellinger, Frederick Askari, Gerald S. Winder, Naba Saeed, Christopher J. Sonnenday, Pratima Sharma, Robert J. Fontana – 22 May 2019 – Tobacco use has been associated with poorer outcomes after liver transplantation (LT). Our study examined the effect on LT listing outcomes of a newly implemented policy prohibiting the use of all tobacco products compared with a prior restrictive policy.

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