Mammalian Target of Rapamycin Complex 1 Signaling Is Required for the Dedifferentiation From Biliary Cell to Bipotential Progenitor Cell in Zebrafish Liver Regeneration

Jianbo He, Jingying Chen, Xiangyong Wei, Hui Leng, Hongliang Mu, Pengcheng Cai, Lingfei Luo – 28 May 2019 – The liver has a high regenerative capacity. Upon two‐thirds partial hepatectomy, the hepatocytes proliferate and contribute to liver regeneration. After severe liver injury, when the proliferation of residual hepatocytes is blocked, the biliary epithelial cells (BECs) lose their morphology and express hepatoblast and endoderm markers, dedifferentiate into bipotential progenitor cells (BP‐PCs), then proliferate and redifferentiate into mature hepatocytes.

Blocking Sodium‐Taurocholate Cotransporting Polypeptide Stimulates Biliary Cholesterol and Phospholipid Secretion in Mice

Reinout L.P. Roscam Abbing, Davor Slijepcevic, Joanne M. Donkers, Rick Havinga, Suzanne Duijst, Coen C. Paulusma, Johan Kuiper, Folkert Kuipers, Albert K. Groen, Ronald P.J. Oude Elferink, Stan F.J. Graaf – 28 May 2019 – Active secretion of bile salts into the canalicular lumen drives bile formation and promotes biliary cholesterol and phospholipid output. Disrupting hepatic bile salt uptake, by inhibition of sodium‐taurocholate cotransporting polypetide (NTCP; Slc10a1) with Myrcludex B, is expected to limit bile salt flux through the liver and thereby to decrease biliary lipid excretion.

Acetyl‐3‐Aminoethyl Salicylate Ameliorates Hepatic Ischemia/Reperfusion Injury and Liver Graft Survival Through a High‐Mobility Group Box 1/Toll‐Like Receptor 4–Dependent Mechanism

Xing Lai, Junhua Gong, Weiming Wang, Ding Cao, Menghao Wang, Yiming Liu, Hao Wu, Yakun Wu, Yong Chen, Zhong Zeng, Jinzheng Li, Jianping Gong – 24 May 2019 – In liver transplant cases, severe hepatic ischemia/reperfusion injury (HIRI) is a strong predictor of adverse liver graft and overall outcomes. During HIRI, high‐mobility group box 1 (HMGB1) promotes hepatocellular death and proinflammatory cytokine secretion by toll‐like receptor 4 (TLR4).

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