Lipoprotein Lipase Up‐regulation in Hepatic Stellate Cells Exacerbates Liver Fibrosis in Nonalcoholic Steatohepatitis in Mice

Toshiaki Teratani, Kengo Tomita, Hirotaka Furuhashi, Nao Sugihara, Masaaki Higashiyama, Makoto Nishikawa, Rie Irie, Takeshi Takajo, Akinori Wada, Kazuki Horiuchi, Kenichi Inaba, Yoshinori Hanawa, Naoki Shibuya, Yoshikiyo Okada, Chie Kurihara, Shin Nishii, Akinori Mizoguchi, Hideaki Hozumi, Chikako Watanabe, Shunsuke Komoto, Shigeaki Nagao, Junji Yamamoto, Soichiro Miura, Ryota Hokari, Tananori Kanai – 6 June 2019 – Lipoprotein lipase (LPL) plays a central role in incorporating plasma lipids into tissues and regulates lipid metabolism and energy balance in the human body.

Childhood Socioeconomic Disadvantage and Risk of Fatty Liver in Adulthood: The Cardiovascular Risk in Young Finns Study

Tomi T. Laitinen, Jussi Vahtera, Katja Pahkala, Costan G. Magnussen, Joel Nuotio, Nina Hutri‐Kähönen, Mika Kivimäki, Terho Lehtimäki, Eero Jokinen, Tomi Laitinen, Päivi Tossavainen, Jaana Pentti, Jorma S.A. Viikari, Markus Juonala, Olli T. Raitakari – 6 June 2019 – Fatty liver is a preventable cause of liver failure, but early risk factors for adulthood fatty liver are poorly understood. We examined the association of childhood socioeconomic disadvantage with adulthood fatty liver and tested adulthood risk factors of fatty liver as possible mediators of this link.

High Risk of Fatty Liver Disease Amplifies the Alanine Transaminase–Lowering Effect of a HSD17B13 Variant

Helene Gellert‐Kristensen, Børge Grønne Nordestgaard, Anne Tybjærg‐Hansen, Stefan Stender – 3 June 2019 – A common loss‐of‐function variant in HSD17B13 (rs72613567:TA) was recently found to protect from chronic liver disease. Whether the variant confers protection from specific risk factors for liver disease is unclear. We tested the association of rs72613567 with plasma levels of alanine transaminase (ALT) and clinical liver disease and mortality in 111,612 individuals from the Danish general population, including 497 with cirrhosis and 113 with hepatocellular carcinoma.

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