Lei Yu, Iris W. Liou, Scott W. Biggins, Matthew Yeh, Florencia Jalikis, Lingtak‐Neander Chan, Jason Burkhead – 26 June 2019 – Copper is an indispensable trace element. It serves as a cofactor for enzymes involved in cellular energy metabolism, antioxidant defense, iron transport, and fibrogenesis. Although these processes are central in the pathogenesis of liver disorders, few studies have attributed them to copper deficiency.

Grace Lai‐Hung Wong, Vincent Wai‐Sun Wong, Becky Wing‐Yan Yuen, Yee‐Kit Tse, Hester Wing‐Sum Luk, Terry Cheuk‐Fung Yip, Vicki Wing‐Ki Hui, Lilian Yan Liang, Grace Chung‐Yan Lui, Henry Lik‐Yuen Chan – 25 June 2019 – Patients with chronic hepatitis B (CHB) are aging because of improved survival under better health care. This has an important implication on the choice of antiviral treatment (AVT), given that long‐term safety would be a concern in the presence of multiple comorbidities.

Omar Y. Mousa, Justin H. Nguyen, Yaohua Ma, Bhupendra Rawal, Kaitlyn R. Musto, Marjorie K. Dougherty, Jefree A. Shalev, Denise M. Harnois – 24 June 2019 – The need for liver transplantation (LT) among older patients is increasing, but the role of LT in the elderly (≥70 years) is not well defined. We retrospectively reviewed all primary LTs from 1998 through 2016 at our center. Survival and associated risk factors were analyzed with Cox regression and Kaplan‐Meier methods for LT recipients in 3 age groups: <60, 60‐69, and ≥70 years.

Alkistis‐Maria Papatheodoridi, Lampros Chrysavgis, Michael Koutsilieris, Antonios Chatzigeorgiou – 23 June 2019 – In recent years, cellular senescence has generated a lot of interest among researchers because of its involvement in both the normal aging process and common human diseases. During senescence, cells undergo alterations that include telomere shortening, nuclear area enlargement, and genomic and mitochondrial DNA damage, leading to irreversible cell cycle arrest, and secretion of proinflammatory cytokines.

Sonja Lang, Yi Duan, Jinyuan Liu, Manolito G. Torralba, Claire Kuelbs, Meritxell Ventura‐Cots, Juan G. Abraldes, Francisco Bosques‐Padilla, Elizabeth C. Verna, Robert S. Brown, Victor Vargas, Jose Altamirano, Juan Caballería, Debbie Shawcross, Michael R. Lucey, Alexandre Louvet, Philippe Mathurin, Guadalupe Garcia‐Tsao, Samuel B. Ho, Xin M. Tu, Ramon Bataller, Peter Stärkel, Derrick E.

Michael H. Le, Yee Hui Yeo, Ramsey Cheung, Linda Henry, Anna S. Lok, Mindie H. Nguyen – 22 June 2019 – Hepatitis B virus (HBV) infection remains a major global health problem, exacerbated by poor linkage to care. We aimed to determine the prevalence of HBV infection, exposure, self‐reported vaccination, vaccine‐induced immunity, disease awareness, and treatment in the United States by birthplace and race/ethnicity during 1999‐2016.

20 June 2019

Richard K. Sterling, Wendy C. King, Abdus S. Wahed, David E. Kleiner, Mandana Khalili, Mark Sulkowski, Raymond T. Chung, Mamta K. Jain, Mauricio Lisker‐Melman, David K. Wong, Marc G. Ghany, the HIV‐HBV Cohort Study of the Hepatitis B Research Network – 20 June 2019 – Noninvasive biomarkers are used increasingly to assess fibrosis in patients with chronic liver disease.

Kathleen B. Schwarz, Philip Rosenthal, Karen F. Murray, Jonathan R. Honegger, Winita Hardikar, Rosie Hague, Naveen Mittal, Benedetta Massetto, Diana M. Brainard, Chia‐Hsiang Hsueh, Jiang Shao, Bandita Parhy, Michael R. Narkewicz, Girish S. Rao, Suzanne Whitworth, Sanjay Bansal, William F. Balistreri – 20 June 2019 – For children under 12 years of age who have chronic hepatitis C virus (HCV) infection, there are currently no approved treatments with direct‐acting antiviral agents.

Varman T. Samuel, Max C. Petersen, Brandon M. Gassaway, Daniel F. Vatner, Jesse Rinehart, Gerald I. Shulman – 20 June 2019