27 June 2019

Julianna C. Hsing, Mindie H. Nguyen, Baiyu Yang, Yan Min, Summer S. Han, Emily Pung, Sandra J. Winter, Xueyin Zhao, Da Gan, Ann W. Hsing, Shankuan Zhu, C. Jason Wang – 27 June 2019 – Nonalcoholic fatty liver disease (NAFLD) is one of the most common forms of liver disease worldwide and has emerged as a significant public health concern in China. A better understanding of the etiology of NAFLD can inform effective management strategies for this disease.

27 June 2019

Daniel J. Firl, Kazunari Sasaki, Vatche G. Agopian, Andre Gorgen, Shoko Kimura, Wethit Dumronggittigule, John C. McVey, Samuele Iesari, Gianluca Mennini, Alessandro Vitale, Armin Finkenstedt, Simona Onali, Maria Hoppe‐Lotichius, Giovanni Vennarecci, Tommaso M. Manzia, Daniele Nicolini, Alfonso W. Avolio, Salvatore Agnes, Marco Vivarelli, Giuseppe Tisone, Giuseppe M. Ettorre, Gerd Otto, Emmanuel Tsochatzis, Massimo Rossi, Andre Viveiros, Umberto Cillo, James F.

Lei Yu, Iris W. Liou, Scott W. Biggins, Matthew Yeh, Florencia Jalikis, Lingtak‐Neander Chan, Jason Burkhead – 26 June 2019 – Copper is an indispensable trace element. It serves as a cofactor for enzymes involved in cellular energy metabolism, antioxidant defense, iron transport, and fibrogenesis. Although these processes are central in the pathogenesis of liver disorders, few studies have attributed them to copper deficiency.

Keiichi Fujiwara, Shin Yasui, Osamu Yokosuka, Naoya Kato – 26 June 2019

Poh Hwa Ooi, Amber Hager, Vera C. Mazurak, Khaled Dajani, Ravi Bhargava, Susan M. Gilmour, Diana R. Mager – 26 June 2019 – Malnutrition is a common complication in patients with end‐stage liver disease (ESLD) awaiting liver transplantation (LT). Malnutrition and sarcopenia overlap in etiology and outcomes, with sarcopenia being defined as reduced skeletal muscle mass and muscle function.

Grace Lai‐Hung Wong, Vincent Wai‐Sun Wong, Becky Wing‐Yan Yuen, Yee‐Kit Tse, Hester Wing‐Sum Luk, Terry Cheuk‐Fung Yip, Vicki Wing‐Ki Hui, Lilian Yan Liang, Grace Chung‐Yan Lui, Henry Lik‐Yuen Chan – 25 June 2019 – Patients with chronic hepatitis B (CHB) are aging because of improved survival under better health care. This has an important implication on the choice of antiviral treatment (AVT), given that long‐term safety would be a concern in the presence of multiple comorbidities.

Omar Y. Mousa, Justin H. Nguyen, Yaohua Ma, Bhupendra Rawal, Kaitlyn R. Musto, Marjorie K. Dougherty, Jefree A. Shalev, Denise M. Harnois – 24 June 2019 – The need for liver transplantation (LT) among older patients is increasing, but the role of LT in the elderly (≥70 years) is not well defined. We retrospectively reviewed all primary LTs from 1998 through 2016 at our center. Survival and associated risk factors were analyzed with Cox regression and Kaplan‐Meier methods for LT recipients in 3 age groups: <60, 60‐69, and ≥70 years.

Alkistis‐Maria Papatheodoridi, Lampros Chrysavgis, Michael Koutsilieris, Antonios Chatzigeorgiou – 23 June 2019 – In recent years, cellular senescence has generated a lot of interest among researchers because of its involvement in both the normal aging process and common human diseases. During senescence, cells undergo alterations that include telomere shortening, nuclear area enlargement, and genomic and mitochondrial DNA damage, leading to irreversible cell cycle arrest, and secretion of proinflammatory cytokines.