Tumor Necrosis Factor Receptor–Associated Factor 6 Promotes Hepatocarcinogenesis by Interacting With Histone Deacetylase 3 to Enhance c‐Myc Gene Expression and Protein Stability

Hua Wu, Tian‐Yu Yang, Yi Li, Wen‐Long Ye, Feng Liu, Xiao‐Shun He, Jing‐Ru Wang, Wen‐Juan Gan, Xiu‐Ming Li, Shen Zhang, Yuan‐Yuan Zhao, Jian‐Ming Li – 3 June 2019 – The oncogene c‐Myc is aberrantly expressed and plays a key role in malignant transformation and progression of hepatocellular carcinoma (HCC). Here, we report that c‐Myc is significantly up‐regulated by tumor necrosis factor receptor–associated factor 6 (TRAF6), an E3 ubiquitin ligase, in hepatocarcinogenesis.

Graft‐Versus‐Tumor Effect in Major Histocompatibility Complex–Mismatched Mouse Liver Transplantation

Dongdong Yu, Lidong Wang, Tianchun Wu, Yaohui Zhang, Yang Tian, Yan Wang, Chenwei Cui, Hui Li, Jinhua Zhang, Lin Zhou, Sheng Yan, Shusen Zheng – 1 June 2019 – Liver transplantation (LT) is currently considered an important method in treating hepatocellular carcinoma (HCC) and an alternative treatment for other liver malignancies. Here, we demonstrated that the graft‐versus‐tumor (GVT) effect exists in allogeneic liver transplantation (allo LT).

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