Dual Roles of Mammalian Target of Rapamycin in Regulating Liver Injury and Tumorigenesis in Autophagy‐Defective Mouse Liver

Hong‐Min Ni, Xiaojuan Chao, Hua Yang, Fengyan Deng, Shaogui Wang, Qingyun Bai, Hui Qian, Yue Cui, Wei Cui, Yinghong Shi, Wei‐Xing Zong, Zhengtao Wang, Li Yang, Wen‐Xing Ding – 16 May 2019 – Autophagy is a lysosomal degradation pathway that degrades cytoplasmic proteins and organelles. Absence of autophagy in hepatocytes has been linked to promoting liver injury and tumorigenesis; however, the mechanisms behind why a lack of autophagy induces these complications are not fully understood.

Dysregulated Autophagy and Lysosome Function Are Linked to Exosome Production by Micro‐RNA 155 in Alcoholic Liver Disease

Mrigya Babuta, Istvan Furi, Shashi Bala, Terence N. Bukong, Patrick Lowe, Donna Catalano, Charles Calenda, Karen Kodys, Gyongyi Szabo – 15 May 2019 – Cellular homeostais, that is normally maintained through autophagy, is disrupted in alcoholic liver disease (ALD). Because autophagy and exosome biogenesis share common elements, we hypothesized that increased exosome production in ALD may be linked to disruption of autophagic function.

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