Bharat Bhushan, Swati Banerjee, Shirish Paranjpe, Kelly Koral, Wendy M. Mars, John W. Stoops, Anne Orr, William C. Bowen, Joseph Locker, George K. Michalopoulos – 7 May 2019 – Epidermal growth factor receptor (EGFR) is a critical regulator of hepatocyte proliferation and liver regeneration. Our recent work indicated that EGFR can also regulate lipid metabolism during liver regeneration after partial hepatectomy. Based on these findings, we investigated the role of EGFR in a mouse model of nonalcoholic fatty liver disease (NAFLD) using a pharmacological inhibition strategy.

Jeanne‐Marie Giard, Jennifer L. Dodge, Norah A. Terrault – 7 May 2019 – Alcohol‐associated liver disease (ALD) is the most common indication for liver transplantation (LT) in the United States and Europe. A 6‐month alcohol abstinence period has been required by many transplant programs prior to listing, which may influence wait‐list (WL) outcomes. Therefore, we examined WL events in patients with ALD versus non‐ALD with a special interest in whether these outcomes differed by sex.

Changyong Li, Yuting Jin, Song Wei, Yishuang Sun, Longfeng Jiang, Qiang Zhu, Douglas G. Farmer, Ronald W. Busuttil, Jerzy W. Kupiec‐Weglinski, Bibo Ke – 7 May 2019 – The Hippo pathway, an evolutionarily conserved protein kinase cascade, tightly regulates cell growth and survival. Activation of yes‐associated protein (YAP), a downstream effector of the Hippo pathway, has been shown to modulate tissue inflammation.

Elliot B. Tapper, Shengchen Hao, Menghan Lin, John N. Mafi, Heather McCurdy, Neehar D. Parikh, Anna S. Lok – 7 May 2019 – Cirrhosis is morbid and increasingly prevalent, yet the U.S. health care system lacks enough physicians and specialists to adequately manage patients with cirrhosis. Although advanced practice providers (APPs) can expand access to cirrhosis‐related care, their impact on the quality of care remains unknown.

Adrian M. Di Bisceglie, Jeffrey Teckman – 6 May 2019

Tanja Blumer, Isabel Fofana, Matthias S. Matter, Xueya Wang, Hesam Montazeri, Diego Calabrese, Mairene Coto‐Llerena, Tujana Boldanova, Sandro Nuciforo, Venkatesh Kancherla, Luigi Tornillo, Salvatore Piscuoglio, Stefan Wieland, Luigi M. Terracciano, Charlotte K.Y. Ng, Markus H. Heim – 6 May 2019 – Hepatocellular carcinoma (HCC) is the second leading cause of cancer‐related deaths worldwide. Treatment options for patients with advanced‐stage disease are limited. A major obstacle in drug development is the lack of an in vivo model that accurately reflects the broad spectrum of human HCC.

Yosuke Ashizawa, Satoshi Kuboki, Hiroyuki Nojima, Hideyuki Yoshitomi, Katsunori Furukawa, Tsukasa Takayashiki, Shigetsugu Takano, Masaru Miyazaki, Masayuki Ohtsuka – 2 May 2019 – Olfactomedin 4 (OLFM4) induces signal transducer and activator of transcription 3 (STAT3) activation by inhibiting gene associated with retinoid‐interferon‐induced mortality 19 (GRIM19), a strong STAT3 suppressor gene; however, the mechanisms of OLFM4 for regulating GRIM19‐STAT3 cascade in hepatocellular carcinoma (HCC) remain unclear.

Sandeep Khurana, Harshit S. Khara – 2 May 2019

Lydia Aye, Michael Volk – 1 May 2019

Koichiro Ohashi, Zhijun Wang, Yoon Mee Yang, Sandrine Billet, Wei Tu, Michael Pimienta, Suzanne L. Cassel, Stephen J. Pandol, Shelly C. Lu, Fayyaz S. Sutterwala, Neil Bhowmick, Ekihiro Seki – 1 May 2019 – Nonalcoholic fatty liver disease (NAFLD) enhances the growth and recurrence of colorectal cancer (CRC) liver metastasis. With the rising prevalence of NAFLD, a better understanding of the molecular mechanism underlying NAFLD‐associated liver metastasis is crucial. Tumor‐associated macrophages (TAMs) constitute a large portion of the tumor microenvironment that promotes tumor growth.