Vasantha L. Kolachala, Sirish K. Palle, Ming Shen, Asha Shenoi, Dmitry M. Shayakhmetov, Nitika A. Gupta – 25 April 2019 – Current understanding is that receptor interacting serine/threonine protein kinase 1 (RIPK1) can lead to two distinct forms of cell death: RIPK3‐mediated necroptosis or caspase 8 (Casp8)‐mediated apoptosis. Here, we report that RIPK1 signaling is indispensable for protection from hepatocellular injury in a steatotic liver undergoing ischemia reperfusion injury (IRI) but not in the lean liver.

George V. Mazariegos, Abhinav Humar – 25 April 2019

Paolo Magistri, Tiziana Olivieri, Giacomo Assirati, Gian Piero Guerrini, Roberto Ballarin, Giuseppe Tarantino, Fabrizio Benedetto – 25 April 2019

Sotiria Bedreli, Katja Straub, Anne Achterfeld, Katharina Willuweit, Antonios Katsounas, Fuat Saner, Heiner Wedemeyer, Kerstin Herzer – 25 April 2019 – Everolimus (EVR) is a mammalian target of rapamycin (mTOR) inhibitor commonly used for immunosuppression (IS) after liver transplantation (LT). However, there are concerns about whether mTOR inhibitors may move the hemostatic balance toward a higher likelihood of thrombosis. The present study aimed to investigate potential coagulation disorders after the administration of EVR.

Nedim Hadžić – 25 April 2019

Yi‐Ming Li, Zhen‐Yu Liu, Jian‐Chao Wang, Jing‐Min Yu, Zhu‐Chun Li, Hai‐Jiao Yang, Juan Tang, Zhi‐Nan Chen – 25 April 2019 – Receptor‐interacting protein kinase 3 (RIP3) is the core regulator that switches cell death from apoptosis to necrosis. However, its role in tumor immunity is unknown. In this study, decreased RIP3 expression was observed in patients with hepatocellular carcinoma (HCC), which correlates with myeloid‐derived suppressor cell (MDSC) accumulation. Moreover, RIP3 is a prognosis factor for patients with HCC.

Amanda J. Chaney, Maria L. Yataco – 23 April 2019 – The evolving role of nurse practitioners (NPs) and physician assistants (PAs) in the United States continues to progress. NP and PA responsibilities have expanded from primary care practices to medical and surgical specialties. They provide acute care in hospitals and intensive care units, and they serve as educators, lobbyists, and researchers. Questions have arisen from NP/PA leaders, physician leaders, and administrators on how to best implement a successful NP/PA model within their practice.

Steven P. O’Hara, Nicholas F. LaRusso – 23 April 2019

Tianpeng Zhang, Min Chen, Lianxia Guo, Fangjun Yu, Cui Zhou, Haiman Xu, Baojian Wu – 23 April 2019 – Metabolic homeostasis of amino acids is essential for human health. Here, we aimed to investigate a potential role for the clock component reverse erythroblastosis virus α (Rev‐erbα) in circadian regulation of amino acid metabolism. RNA‐seq with Rev‐erbα‐/‐ mice showed expression changes in genes involved in amino acid metabolism, particularly, the urea cycle and methionine metabolism.

Veeral H. Ajmera, Edward Cachay, Christian Ramers, Irine Vodkin, Shirin Bassirian, Seema Singh, Neeraj Mangla, Richele Bettencourt, Jeannette L.