Hepatocyte‐Specific β‐Catenin Deletion During Severe Liver Injury Provokes Cholangiocytes to Differentiate Into Hepatocytes

Jacquelyn O. Russell, Wei‐Yu Lu, Hirohisa Okabe, Marc Abrams, Michael Oertel, Minakshi Poddar, Sucha Singh, Stuart J. Forbes, Satdarshan P. Monga – 14 September 2018 – Liver regeneration after injury is normally mediated by proliferation of hepatocytes, although recent studies have suggested biliary epithelial cells (BECs) can differentiate into hepatocytes during severe liver injury when hepatocyte proliferation is impaired. We investigated the effect of hepatocyte‐specific β‐catenin deletion in recovery from severe liver injury and BEC‐to‐hepatocyte differentiation.

Hepatocyte‐Specific β‐Catenin Deletion During Severe Liver Injury Provokes Cholangiocytes to Differentiate Into Hepatocytes

Jacquelyn O. Russell, Wei‐Yu Lu, Hirohisa Okabe, Marc Abrams, Michael Oertel, Minakshi Poddar, Sucha Singh, Stuart J. Forbes, Satdarshan P. Monga – 14 September 2018 – Liver regeneration after injury is normally mediated by proliferation of hepatocytes, although recent studies have suggested biliary epithelial cells (BECs) can differentiate into hepatocytes during severe liver injury when hepatocyte proliferation is impaired. We investigated the effect of hepatocyte‐specific β‐catenin deletion in recovery from severe liver injury and BEC‐to‐hepatocyte differentiation.

Changes in Cerebral Hemodynamics in Patients With Cirrhosis After Liver Transplantation

Ricardo Ulises Macías‐Rodríguez, Astrid Ruiz‐Margáin, Carlos Cantú‐Brito, Daniel Fernando Flores‐Silva, Octavio René García‐Flores, Francisco Javier Cubero, Elena Larrieta‐Carrasco, Aldo Torre – 12 September 2018 – Improvement in cognitive function after orthotopic liver transplantation (LT) has been demonstrated in the acute setting immediately after LT and in acute liver failure. However, the longterm changes in cerebral hemodynamics after LT remain unexplored. Therefore, we aimed to evaluate the longterm changes in cerebral hemodynamics of patients with cirrhosis after LT.

De Novo Malignancies Screening After Liver Transplantation for Alcoholic Liver Disease: A Comparative Opportunistic Study

Laurence Renaud, Marie‐Noëlle Hilleret, Elsa Thimonier, Olivier Guillaud, Francois Arbib, Gilbert Ferretti, Adrien Jankowski, Christine Chambon‐Augoyard, Domitille Erard‐Poinsot, Thomas Decaens, Olivier Boillot, Vincent Leroy, Jérôme Dumortier – 12 September 2018 – Patients having received a liver transplantation (LT) for alcoholic liver disease (ALD) have a high risk of de novo malignancies, especially in the upper aerodigestive tract and lungs due to their smoking and alcohol history.

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