aPKC‐ι/P‐Sp1/Snail signaling induces epithelial–mesenchymal transition and immunosuppression in cholangiocarcinoma

Yawei Qian, Wei Yao, Tao Yang, Yan Yang, Yan Liu, Qi Shen, Jian Zhang, Weipeng Qi, Jianming Wang – 2 June 2017 – Cholangiocarcinoma (CCA) is a highly malignant bile duct cancer that tends to invade and metastasize early. The epithelial–mesenchymal transition (EMT) has been implicated in cancer cell invasion and metastasis, as well as in cancer cell evasion of host immunity. In this study, we investigated the interaction between atypical protein kinase C‐iota (aPKC‐ι) and Snail in the regulation of EMT and its relationship to CCA immunosuppression.

Serum extracellular vesicles contain protein biomarkers for primary sclerosing cholangitis and cholangiocarcinoma

Ander Arbelaiz, Mikel Azkargorta, Marcin Krawczyk, Alvaro Santos‐Laso, Ainhoa Lapitz, Maria J. Perugorria, Oihane Erice, Esperanza Gonzalez, Raul Jimenez‐Agüero, Adelaida Lacasta, Cesar Ibarra, Alberto Sanchez‐Campos, Juan P. Jimeno, Frank Lammert, Piotr Milkiewicz, Marco Marzioni, Rocio I.R. Macias, Jose J.G. Marin, Tushar Patel, Gregory J. Gores, Ibon Martinez, Félix Elortza, Juan M. Falcon‐Perez, Luis Bujanda, Jesus M. Banales – 26 May 2017 – Cholangiocarcinoma (CCA) includes a heterogeneous group of biliary cancers with poor prognosis.

Serum extracellular vesicles contain protein biomarkers for primary sclerosing cholangitis and cholangiocarcinoma

Ander Arbelaiz, Mikel Azkargorta, Marcin Krawczyk, Alvaro Santos‐Laso, Ainhoa Lapitz, Maria J. Perugorria, Oihane Erice, Esperanza Gonzalez, Raul Jimenez‐Agüero, Adelaida Lacasta, Cesar Ibarra, Alberto Sanchez‐Campos, Juan P. Jimeno, Frank Lammert, Piotr Milkiewicz, Marco Marzioni, Rocio I.R. Macias, Jose J.G. Marin, Tushar Patel, Gregory J. Gores, Ibon Martinez, Félix Elortza, Juan M. Falcon‐Perez, Luis Bujanda, Jesus M. Banales – 26 May 2017 – Cholangiocarcinoma (CCA) includes a heterogeneous group of biliary cancers with poor prognosis.

Recommendations on the use of magnetic resonance imaging in PSC‐A position statement from the International PSC Study Group

Christoph Schramm, John Eaton, Kristina I. Ringe, Sudhakar Venkatesh, Jin Yamamura, for the MRI working group of the IPSCSG – 26 May 2017 – Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disorder characterized by inflammation and fibrosis of the intra‐ and/or extrahepatic bile ducts. Magnetic resonance imaging (MRI) is a noninvasive imaging modality that can be used to diagnose PSC and detect disease related complications. Quantitative MRI technologies also have the potential to provide valuable prognostic information.

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