Iván Posso‐Osorio, Tatiana Méndez‐Rayo, Carlos‐Andrés Jimenez, Diana Escobar, Mauricio Sepúlveda, Erika‐Paola Navarro, Gabriel J. Tobón – 18 May 2017

Chun‐Seok Cho, David B. Lombard, Jun Hee Lee – 18 May 2017

Jörg‐Martin Bangen, Linda Hammerich, Roland Sonntag, Maike Baues, Ute Haas, Daniela Lambertz, Thomas Longerich, Twan Lammers, Frank Tacke, Christian Trautwein, Christian Liedtke – 18 May 2017 – Initiation and progression of liver fibrosis requires proliferation and activation of resting hepatic stellate cells (HSCs). Cyclin E1 (CcnE1) is the regulatory subunit of the cyclin‐dependent kinase 2 (Cdk2) and controls cell cycle re‐entry. We have recently shown that genetic inactivation of CcnE1 prevents activation, proliferation, and survival of HSCs and protects from liver fibrogenesis.

Mariya L. Samoylova, Mark J. Nigrini, Jennifer L. Dodge, John P. Roberts – 18 May 2017 – We investigated the possibility that patients with hepatocellular carcinoma (HCC) listed for liver transplant with tumors just outside stage T2 size criteria may be inaccurately reported as just meeting the tumor size criteria for transplant. The United Network for Organ Sharing/Standard Transplant Analysis and Research database identified 12,958 patients listed for liver transplants with HCC exception points from 2006 to 2013, 9,168 of whom were listed with one tumor.

Tanja Cvitanović, Matthias C. Reichert, Miha Moškon, Miha Mraz, Frank Lammert, Damjana Rozman – 18 May 2017 – Understanding the dynamics of human liver metabolism is fundamental for effective diagnosis and treatment of liver diseases. This knowledge can be obtained with systems biology/medicine approaches that account for the complexity of hepatic responses and their systemic consequences in other organs.

Soumik BasuRay, Eriks Smagris, Jonathan C. Cohen, Helen H. Hobbs – 18 May 2017 – A sequence variation (I148M) in patatin‐like phospholipase domain‐containing protein 3 (PNPLA3) is strongly associated with fatty liver disease, but the underlying mechanism remains obscure. In this study, we used knock‐in (KI) mice (Pnpla3148M/M) to examine the mechanism responsible for accumulation of triglyceride (TG) and PNPLA3 in hepatic lipid droplets (LDs). No differences were found between Pnpla3148M/M and Pnpla3+/+ mice in hepatic TG synthesis, utilization, or secretion.

Sergio A. Sánchez‐Luna, Kyle E. Brown – 18 May 2017 – Hereditary hemochromatosis (HH) can cause cirrhosis and hepatocellular carcinoma (HCC), but the frequency of these complications is controversial. To address this question, we reviewed the experience with HH at an academic medical center that is the sole liver transplantation center in a state with a population that is >90% Caucasian.

Kentaro Tominaga, Kenya Kamimura, Akira Sakamaki, Shuji Terai – 18 May 2017

Vinay Sundaram, Jane Lim, Danielle M. Tholey, Sentia Iriana, Irene Kim, Vignan Manne, Nicholas N. Nissen, Andrew S. Klein, Tram T. Tran, Walid S. Ayoub, Barry Schlansky – 17 May 2017 – The Braden Scale is a standardized tool to assess pressure ulcer risk that is reported for all hospitalized patients in the United States per requirements of the Center for Medicare and Medicaid Services. Previous data have shown the Braden Scale can predict both frailty and mortality risk in patients with decompensated cirrhosis.

Jashdeep Bhattacharjee, Michelle Kirby, Samir Softic, Lili Miles, Rosa‐Maria Salazar‐Gonzalez, Pranav Shivakumar, Rohit Kohli – 16 May 2017 – Hepatic inflammation is a key pathologic feature of nonalcoholic steatohepatitis (NASH). Natural killer T (NKT) cells and clusters of differentiation (CD)8+ T‐cells are known to play an important role in obesity‐related adipose tissue inflammation. We hypothesized that these same inflammatory phenotypes would be present in progressive NASH.