The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation

Soumik BasuRay, Eriks Smagris, Jonathan C. Cohen, Helen H. Hobbs – 18 May 2017 – A sequence variation (I148M) in patatin‐like phospholipase domain‐containing protein 3 (PNPLA3) is strongly associated with fatty liver disease, but the underlying mechanism remains obscure. In this study, we used knock‐in (KI) mice (Pnpla3148M/M) to examine the mechanism responsible for accumulation of triglyceride (TG) and PNPLA3 in hepatic lipid droplets (LDs). No differences were found between Pnpla3148M/M and Pnpla3+/+ mice in hepatic TG synthesis, utilization, or secretion.

Clinical burden of liver disease from hemochromatosis at an academic medical center

Sergio A. Sánchez‐Luna, Kyle E. Brown – 18 May 2017 – Hereditary hemochromatosis (HH) can cause cirrhosis and hepatocellular carcinoma (HCC), but the frequency of these complications is controversial. To address this question, we reviewed the experience with HH at an academic medical center that is the sole liver transplantation center in a state with a population that is >90% Caucasian.

The Braden Scale, A standard tool for assessing pressure ulcer risk, predicts early outcomes after liver transplantation

Vinay Sundaram, Jane Lim, Danielle M. Tholey, Sentia Iriana, Irene Kim, Vignan Manne, Nicholas N. Nissen, Andrew S. Klein, Tram T. Tran, Walid S. Ayoub, Barry Schlansky – 17 May 2017 – The Braden Scale is a standardized tool to assess pressure ulcer risk that is reported for all hospitalized patients in the United States per requirements of the Center for Medicare and Medicaid Services. Previous data have shown the Braden Scale can predict both frailty and mortality risk in patients with decompensated cirrhosis.

Hepatic natural killer T‐cell and CD8+ T‐cell signatures in mice with nonalcoholic steatohepatitis

Jashdeep Bhattacharjee, Michelle Kirby, Samir Softic, Lili Miles, Rosa‐Maria Salazar‐Gonzalez, Pranav Shivakumar, Rohit Kohli – 16 May 2017 – Hepatic inflammation is a key pathologic feature of nonalcoholic steatohepatitis (NASH). Natural killer T (NKT) cells and clusters of differentiation (CD)8+ T‐cells are known to play an important role in obesity‐related adipose tissue inflammation. We hypothesized that these same inflammatory phenotypes would be present in progressive NASH.

Risk factors for recurrence of primary biliary cholangitis after liver transplantation in female patients: A Japanese multicenter retrospective study

Tomomi Kogiso, Hiroto Egawa, Satoshi Teramukai, Makiko Taniai, Etsuko Hashimoto, Katsutoshi Tokushige, Shotaro Sakisaka, Satomi Sakabayashi, Masakazu Yamamoto, Koji Umeshita, Shinji Uemoto – 16 May 2017 – Primary biliary cholangitis (PBC) is diagnosed mainly in female individuals, and risk factors for PBC recurrence (rPBC) after liver transplantation (LT) from cadaveric donors have been reported. We conducted a retrospective multicenter study of rPBC in female patients after living‐donor LT (LDLT).

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