Toward novel immunocompetent animal models for hepatitis B virus infection
Laurent Mailly, Mirjam B. Zeisel, Thomas F. Baumert – 3 May 2017
Toward novel immunocompetent animal models for hepatitis B virus infection
Laurent Mailly, Mirjam B. Zeisel, Thomas F. Baumert – 3 May 2017
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Neehar D. Parikh, Amit G. Singal, Anna S. Lok, Rajesh Balkrishnan, Vahakn Shahinian, Vincent D. Marshall – 3 May 2017
How healthy are the “Healthy volunteers”? Penetrance of NAFLD in the biomedical research volunteer pool
Varun Takyar, Anand Nath, Andrea Beri, Ahmed M. Gharib, Yaron Rotman – 3 May 2017 – Healthy volunteers are crucial for biomedical research. Inadvertent inclusion of subjects with nonalcoholic fatty liver disease (NAFLD) as controls can compromise study validity and subject safety. Given the rising prevalence of NAFLD in the general population, we sought to identify its prevalence and potential impact in volunteers for clinical trials. We conducted a cross‐sectional study of subjects who were classified as healthy volunteers between 2011 and 2015 and had no known liver disease.
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3 May 2017
Pentamidine blocks hepatotoxic injury in mice
Enpeng Zhao, Ghulam Ilyas, Francesca Cingolani, Jae Ho Choi, François Ravenelle, Kathryn E. Tanaka, Mark J. Czaja – 3 May 2017 – Toxin‐induced liver diseases lack effective therapies despite increased understanding of the role factors such as an overactive innate immune response play in the pathogenesis of this form of hepatic injury. Pentamidine is an effective antimicrobial agent against several human pathogens, but studies have also suggested that this drug inhibits inflammation.
Autoreactive monoclonal antibodies from patients with primary biliary cholangitis recognize environmental xenobiotics
Toshihiro Tanaka, Weici Zhang, Ying Sun, Zongwen Shuai, Asiya Seema Chida, Thomas P. Kenny, Guo‐Xiang Yang, Ignacio Sanz, Aftab Ansari, Christopher L. Bowlus, Gregory C. Ippolito, Ross L. Coppel, Kazuichi Okazaki, Xiao‐Song He, Patrick S.C. Leung, M. Eric Gershwin – 3 May 2017 – A major problem in autoimmunity has been identification of the earliest events that lead to breach of tolerance.
Cellular senescence, neuropeptides and hepatic fibrosis: Additional insights into increasing complexity
Steven P. O'Hara, Nicholas F. La Russo – 2 May 2017
Alcohol abstinence ameliorates the dysregulated immune profiles in patients with alcoholic hepatitis: A prospective observational study
Wei Li, Tohti Amet, Yanyan Xing, Dennis Yang, Suthat Liangpunsakul, Puneet Puri, Patrick S. Kamath, Arun J. Sanyal, Vijay H. Shah, Barry P. Katz, Svetlana Radaeva, David W. Crabb, Naga Chalasani, Qigui Yu – 2 May 2017 – Alcoholic hepatitis (AH) develops in only a small proportion of heavy drinkers. To better understand the mechanisms underlying this disparity, we conducted a study to define the relationship between AH development and dysregulated immune responses that might be ameliorated by alcohol abstinence.
Main drivers of outcome differ between short term and long term in severe alcoholic hepatitis: A prospective study
Alexandre Louvet, Julien Labreuche, Florent Artru, Alexis Bouthors, Benjamin Rolland, Pierre Saffers, Julien Lollivier, Elise Lemaître, Sébastien Dharancy, Guillaume Lassailly, Valérie Canva‐Delcambre, Alain Duhamel, Philippe Mathurin – 29 April 2017 – Understanding the mechanisms of outcome according to the time frame can help optimize the therapeutic development in severe alcoholic hepatitis.