Hepatitis B virus infection and decreased risk of nonalcoholic fatty liver disease: A cohort study
Chia‐Chi Wang, Jia‐Horng Kao – 8 May 2017
Mesenchymal stem cells attenuate acute liver injury by altering ratio between interleukin 17 producing and regulatory natural killer T cells
Neda Milosavljevic, Marina Gazdic, Bojana Simovic Markovic, Aleksandar Arsenijevic, Jasmin Nurkovic, Zana Dolicanin, Valentin Djonov, Miodrag L. Lukic, Vladislav Volarevic – 8 May 2017 – Mesenchymal stem cells (MSCs) are, due to immunomodulatory characteristics, considered as novel agents in the treatment of immune‐mediated acute liver failure. Although it is known that MSCs can regulate activation of T lymphocytes, their capacity to modulate function of neutrophils and natural killer T (NKT) cells, major interleukin (IL) 17–producing cells in acute liver injury, is still unknown.
The clinical outcomes of patients with portal vein tumor thrombi after living donor liver transplantation
Ho Joong Choi, Dong Goo Kim, Gun Hyung Na, Tae Ho Hong, Si Hyun Bae, Young Kyoung You, Jong Young Choi, Seung Kew Yoon – 8 May 2017 – The purpose of this study was to evaluate the feasibility of living donor liver transplantation for treatment of patients with hepatocellular carcinoma and segmental portal vein tumor thrombus (PVTT) below the second‐order branch. Between January 2005 and December 2015, we retrospectively analyzed 242 patients in a control group (n = 184), a microvascular invasion (MVI) group (n = 24), and a PVTT group (n = 34).
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Eun‐Jeong Joo, Yoosoo Chang, Seungho Ryu – 8 May 2017
Tips and pitfalls in direct ligation of large spontaneous splenorenal shunt during liver transplantation
Hyeyoung Kim, Kyung Chul Yoon, Kwang‐Woong Lee, Nam‐Joon Yi, Hae Won Lee, YoungRok Choi, Dongkyu Oh, Hyo‐Sin Kim, Suk Kyun Hong, Sung Woo Ahn, Kyung‐Suk Suh – 8 May 2017 – Patients with large spontaneous splenorenal shunts (SRSs) prove challenging during liver transplantation (LT), regardless of organizing portal vein (PV) thrombosis. Here, we detail the clinical outcomes of 26 patients who underwent direct ligation of large SRSs during LT. Direct ligation of large SRS was applied in poor portal flow during LT.
Impact of transplant accessibility for sensitized patients by avoiding unacceptable antigens
Arnaud Del Bello, Nicolas Congy‐Jolivet, Benoit Audry, Corinne Antoine, Laure Esposito, Anne‐Laure Hebral, Nassim Kamar – 6 May 2017 – Recent data have confirmed the negative impact of preformed donor‐specific antibodies (pDSAs) after liver transplantation (LT).
Interview with American Association for the Study of Liver Diseases president Dr. Anna Lok
Anna S.F. Lok – 3 May 2017
How healthy are the “Healthy volunteers”? Penetrance of NAFLD in the biomedical research volunteer pool
Varun Takyar, Anand Nath, Andrea Beri, Ahmed M. Gharib, Yaron Rotman – 3 May 2017 – Healthy volunteers are crucial for biomedical research. Inadvertent inclusion of subjects with nonalcoholic fatty liver disease (NAFLD) as controls can compromise study validity and subject safety. Given the rising prevalence of NAFLD in the general population, we sought to identify its prevalence and potential impact in volunteers for clinical trials. We conducted a cross‐sectional study of subjects who were classified as healthy volunteers between 2011 and 2015 and had no known liver disease.
Acetyl‐coenzyme A carboxylase inhibition reduces de novo lipogenesis in overweight male subjects: A randomized, double‐blind, crossover study
Kathryn Stiede, Wenyan Miao, Heather S. Blanchette, Carine Beysen, Geraldine Harriman, H. James Harwood, Heather Kelley, Rosana Kapeller, Tess Schmalbach, William F. Westlin – 3 May 2017 – NDI‐010976, an allosteric inhibitor of acetyl‐coenzyme A carboxylases (ACC) ACC1 and ACC2, reduces hepatic de novo lipogenesis (DNL) and favorably affects steatosis, inflammation, and fibrosis in animal models of fatty liver disease.