Donor PNPLA3 rs738409 genotype affects fibrosis progression in liver transplantation for hepatitis C

Winston Dunn, Maura O'Neil, Jie Zhao, Chuang Hong Wu, Benjamin Roberts, Shweta Chakraborty, Craig Sherman, Brandy Weaver, Ryan Taylor, Jody Olson, Mojtaba Olyaee, Richard Gilroy, Timothy Schmitt, Yu‐Jui Yvonne Wan, Steven A. Weinman – 1 October 2013 – The rs738409 G>C single nucleotide polymorphism occurring in the patatin‐like phospholipase 3 gene has been identified as a novel genetic marker for hepatic steatosis. Recent studies also associated rs738409 with fibrosis in hepatitis C (HCV).

Endothelin‐1 receptor A blocker darusentan decreases hepatic changes and improves liver repopulation after cell transplantation in rats

Ralf Bahde, Sorabh Kapoor, Preeti Viswanathan, Hans‐Ullrich Spiegel, Sanjeev Gupta – 1 October 2013 – Cell transplantation‐induced hepatic ischemia and recruitment of vasoconstrictors (e.g., endothelin‐1; Edn1) leads to clearance of transplanted cells and poses problems for liver repopulation. Therefore, we determined whether darusentan (DAR), which potently blocks Edn1 receptor type A, could benefit cell engraftment. We transplanted primary F344 rat hepatocytes with or without DAR in dipeptidyl peptidase IV–deficient rats.

Neoadjuvant stereotactic body radiation therapy, capecitabine, and liver transplantation for unresectable hilar cholangiocarcinoma

Theodore H. Welling, Mary Feng, Shanshan Wan, Sin Ye Hwang, Michael L. Volk, Theodore S. Lawrence, Mark M. Zalupski, Christopher J. Sonnenday – 1 October 2013 – Hilar cholangiocarcinoma (CCA) is a difficult malignancy to treat surgically because of its anatomical location and its frequent association with primary sclerosing cholangitis. Neoadjuvant chemoradiotherapy followed by liver transplantation in lymph node–negative patients has been advanced by select liver transplant centers for the treatment of patients with unresectable disease.

On‐treatment alpha‐fetoprotein is a specific tumor marker for hepatocellular carcinoma in patients with chronic hepatitis B receiving entecavir

Grace L.H. Wong, Henry L.Y. Chan, Yee‐Kit Tse, Hoi‐Yun Chan, Chi‐Hang Tse, Angeline O.S. Lo, Vincent W.S. Wong – 1 October 2013 – Alpha‐fetoprotein (AFP) is the most widely used biomarker for hepatocellular carcinoma (HCC) surveillance, which is criticized as neither sensitive nor specific in active hepatitis and liver cirrhosis. The aim of this study was to determine the performance of AFP as a tumor marker for HCC in entecavir‐treated patients with chronic hepatitis B (CHB).

G‐protein‐coupled receptor 30/adenylyl cyclase/protein kinase A pathway is involved in estradiol 17ß‐d‐glucuronide‐induced cholestasis

Andrés E. Zucchetti, Ismael R. Barosso, Andrea C. Boaglio, Cecilia L. Basiglio, Gisel Miszczuk, M. Cecilia Larocca, M. Laura Ruiz, Carlos A. Davio, Marcelo G. Roma, Fernando A. Crocenzi, Enrique J.

Opposing effects of prednisolone treatment on T/NKT cell‐ and hepatotoxin‐mediated hepatitis in mice

Hyo‐Jung Kwon, Young‐Suk Won, Ogyi Park, Dechun Feng, Bin Gao – 1 October 2013 – Prednisolone is a corticosteroid that has been used to treat inflammatory liver diseases such as autoimmune hepatitis and alcoholic hepatitis. However, the results have been controversial, and how prednisolone affects liver disease progression remains unknown.

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