Therapeutic recovery of hepatitis B virus (HBV)‐induced hepatocyte‐intrinsic immune defect reverses systemic adaptive immune tolerance

Peixiang Lan, Cai Zhang, Qiuju Han, Jian Zhang, Zhigang Tian – 27 February 2013 – Hepatitis B virus (HBV) persistence aggravates hepatic immunotolerance, leading to the failure of cell‐intrinsic type I interferon and antiviral response, but whether and how HBV‐induced hepatocyte‐intrinsic tolerance influences systemic adaptive immunity has never been reported, which is becoming the major obstacle for chronic HBV therapy.

Liver transplantation for children with biliary atresia in the pediatric end‐stage liver disease era: The role of insurance status

Ronen Arnon, Rachel A. Annunziato, Asha Willis, Meera Parbhakar, Jaime Chu, Nanda Kerkar, Benjamin L. Shneider – 27 February 2013 – Socioeconomic status influences health outcomes, although its impact on liver transplantation (LT) in children with biliary atresia (BA) is unknown. We hypothesized that governmental insurance [public insurance (PU)], rather than private insurance (PR), would be associated with poorer outcomes for children with BA.

Strengthening protections for human subjects: Proposed restrictions on the publication of transplant research involving prisoners

Maryam Valapour, Kristin M. Paulson, Alisha Hilde – 27 February 2013 – Publication is one of the primary rewards in the academic research community and is the first step in the dissemination of a new discovery that could lead to recognition and opportunity. Because of this, the publication of research can serve as a tacit endorsement of the methodology behind the science. This becomes a problem when vulnerable populations that are incapable of giving legitimate informed consent, such as prisoners, are used in research.

Cholestasis in a patient with gallstones and a normal gamma‐glutamyl transferase

Sheida Moghadamrad, Matteo Montani, Rosemarie Weimann, Andrea De Gottardi – 27 February 2013 – Cholestasis with normal gamma glutamyl transferase characterizes functional deficiencies in the gene ABCB11, which encodes the bile salt export pump (BSEP), a liver‐specific adenosine triphosphate (ATP)‐binding cassette transporter. Here we report the case of a patient presenting with features of benign recurrent intrahepatic cholestasis associated with a heterozygous mutation in the ABCB11 gene.

Left hepatectomy versus right hepatectomy for living donor liver transplantation: Shifting the risk from the donor to the recipient

Garrett R. Roll, Justin R. Parekh, William F. Parker, Mark Siegler, Elizabeth A. Pomfret, Nancy L. Ascher, John Paul Roberts – 27 February 2013 – Living donor liver transplantation (LDLT), originally used in children with left lateral segment grafts, has been expanded to adults who require larger grafts to support liver function. Most adult LDLT procedures have been performed with right lobe grafts, and this means a significant risk of morbidity for the donors. To minimize the donor risk for adults, there is renewed interest in smaller left lobe grafts.

Sorafenib perpetuates cellular anticancer effector functions by modulating the crosstalk between macrophages and natural killer cells

Martin Franz Sprinzl, Florian Reisinger, Andreas Puschnik, Marc Ringelhan, Kerstin Ackermann, Daniel Hartmann, Matthias Schiemann, Arndt Weinmann, Peter Robert Galle, Marcus Schuchmann, Helmut Friess, Gerd Otto, Mathias Heikenwalder, Ulrike Protzer – 19 February 2013 – Alternatively polarized macrophages (Mϕ) shape the microenvironment of hepatocellular carcinoma (HCC) and temper anticancer immune responses. We investigated if sorafenib alters the HCC microenvironment by restoring classical macrophage polarization and triggering tumor‐directed natural killer (NK) cell responses.

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