Excellent quality of life after liver transplantation for patients with perihilar cholangiocarcinoma who have undergone neoadjuvant chemoradiation

Sarwa Darwish Murad, Julie K. Heimbach, Gregory J. Gores, Charles B. Rosen, Joanne T. Benson, W. Ray Kim – 27 February 2013 – Patients with perihilar cholangiocarcinoma (CCA) undergoing neoadjuvant chemoradiation followed by liver transplantation (LT) have excellent survival. However, little is known about their quality of life (QOL). We assessed the QOL of these patients and compared it to the QOL of patients who underwent transplantation for other liver diseases. From 1993 to 2010, 129 CCA patients underwent LT, and 93 (72%) were alive as of November 2010.

Desmosterol in human nonalcoholic steatohepatitis

Marko Simonen, Ville Männistö, Joel Leppänen, Dorota Kaminska, Vesa Kärjä, Sari Venesmaa, Pirjo Käkelä, Johanna Kuusisto, Helena Gylling, Markku Laakso, Jussi Pihlajamäki – 27 February 2013 – Dysregulation of the cholesterol synthesis pathway and accumulation of cholesterol in the liver are linked to the pathogenesis of nonalcoholic steatohepatitis (NASH). Therefore, we investigated the association of serum and liver levels of cholesterol precursors with NASH.

Visualization of stem cell features in human hepatocellular carcinoma reveals in vivo significance of tumor‐host interaction and clinical course

Shunsuke Muramatsu, Shinji Tanaka, Kaoru Mogushi, Rama Adikrisna, Arihiro Aihara, Daisuke Ban, Takanori Ochiai, Takumi Irie, Atsushi Kudo, Noriaki Nakamura, Koh Nakayama, Hiroshi Tanaka, Shoji Yamaoka, Shigeki Arii – 27 February 2013 – Hepatocellular carcinoma (HCC) is one of the most aggressive malignancies because of recurrence and/or metastasis even after curative resection. Emerging evidence suggests that tumor metastasis and recurrence might be driven by a small subpopulation of stemness cells, so‐called cancer stem cells (CSCs).

Liver stiffness is influenced by a standardized meal in patients with chronic hepatitis C virus at different stages of fibrotic evolution

Umberto Arena, Monica Lupsor Platon, Cristina Stasi, Stefania Moscarella, Alì Assarat, Giorgio Bedogni, Valeria Piazzolla, Radu Badea, Giacomo Laffi, Fabio Marra, Alessandra Mangia, Massimo Pinzani – 27 February 2013 – Transient elastography (TE) is increasingly employed in clinical practice for the noninvasive detection of tissue fibrosis in patients with chronic liver disease (CLD), and particularly chronic hepatitis C virus (HCV)‐related hepatitis.

Cholestasis in a patient with gallstones and a normal gamma‐glutamyl transferase

Sheida Moghadamrad, Matteo Montani, Rosemarie Weimann, Andrea De Gottardi – 27 February 2013 – Cholestasis with normal gamma glutamyl transferase characterizes functional deficiencies in the gene ABCB11, which encodes the bile salt export pump (BSEP), a liver‐specific adenosine triphosphate (ATP)‐binding cassette transporter. Here we report the case of a patient presenting with features of benign recurrent intrahepatic cholestasis associated with a heterozygous mutation in the ABCB11 gene.

Liver stiffness is influenced by a standardized meal in patients with chronic hepatitis C virus at different stages of fibrotic evolution

Umberto Arena, Monica Lupsor Platon, Cristina Stasi, Stefania Moscarella, Alì Assarat, Giorgio Bedogni, Valeria Piazzolla, Radu Badea, Giacomo Laffi, Fabio Marra, Alessandra Mangia, Massimo Pinzani – 27 February 2013 – Transient elastography (TE) is increasingly employed in clinical practice for the noninvasive detection of tissue fibrosis in patients with chronic liver disease (CLD), and particularly chronic hepatitis C virus (HCV)‐related hepatitis.

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