The sexual transmission rate of HCV among heterosexual couples
Bart P.X. Grady, Maria Prins, Maarten Schim Loeff – 19 February 2013
Elastin‐based molecular MRI of liver fibrosis
Josef Ehling, Matthias Bartneck, Viktor Fech, Britta Butzbach, Richard Cesati, Rene Botnar, Twan Lammers, Frank Tacke – 19 February 2013
Interstrain differences in chronic hepatitis and tumor development in a murine model of inflammation‐mediated hepatocarcinogenesis
Tamara Potikha, Evgeniy Stoyanov, Orit Pappo, Antonina Frolov, Lina Mizrahi, Deborah Olam, Temima Shnitzer‐Perlman, Ido Weiss, Neta Barashi, Amnon Peled, Gabriele Sass, Gisa Tiegs, Francoise Poirier, Gabriel A. Rabinovich, Eithan Galun, Daniel Goldenberg – 19 February 2013 – Chronic inflammation is strongly associated with an increased risk for hepatocellular carcinoma (HCC) development.
Taurolithocholate‐induced MRP2 retrieval involves MARCKS phosphorylation by protein kinase Cϵ in HUH‐NTCP Cells
Christopher M. Schonhoff, Cynthia R. L. Webster, M. Sawkat Anwer – 19 February 2013 – Taurolithocholate (TLC) acutely inhibits the biliary excretion of multidrug‐resistant associated protein 2 (Mrp2) substrates by inducing Mrp2 retrieval from the canalicular membrane, whereas cyclic adenosine monophosphate (cAMP) increases plasma membrane (PM)–MRP2. The effect of TLC may be mediated via protein kinase Cϵ (PKCϵ). Myristoylated alanine‐rich C kinase substrate (MARCKS) is a membrane‐bound F‐actin crosslinking protein and is phosphorylated by PKCs.
Reply to Elastin‐based molecular MRI of liver fibrosis
Antonella Pellicoro, John P. Iredale – 19 February 2013
Jay Donald Ostrow: The yellow giant
Claudio Tiribelli, Libor Vitek, Richard P. Wennberg – 19 February 2013
Frequency of the cholesteryl ester storage disease common LIPA E8SJM mutation (c.894G>A) in various racial and ethnic groups
Stuart A. Scott, Benny Liu, Irina Nazarenko, Suparna Martis, Julia Kozlitina, Yao Yang, Charina Ramirez, Yumi Kasai, Tommy Hyatt, Inga Peter, Robert J. Desnick – 19 February 2013 – Cholesteryl ester storage disease (CESD) and Wolman disease are autosomal recessive later‐onset and severe infantile disorders, respectively, which result from the deficient activity of lysosomal acid lipase (LAL). LAL is encoded by LIPA (10q23.31) and the most common mutation associated with CESD is an exon 8 splice junction mutation (c.894G>A; E8SJM), which expresses only ∼3%‐5% of normally spliced LAL.
Advances in endoscopic management of biliary tract complications after liver transplantation
Mustafa A. Arain, Rajeev Attam, Martin L. Freeman – 15 February 2013 – Biliary tract complications after liver transplantation (LT) most commonly include biliary leaks, strictures, and stone disease. Living donor recipients and donation after cardiac death recipients are at an increased risk of developing biliary complications. Biliary leaks usually occur early after transplantation, whereas strictures and stone disease occur later. The diagnosis of biliary complications relies on a combination of clinical presentation, laboratory abnormalities, and imaging modalities.
Deficiency of intestinal mucin‐2 ameliorates experimental alcoholic liver disease in mice
Phillipp Hartmann, Peng Chen, Hui J. Wang, Lirui Wang, Declan F. McCole, Katharina Brandl, Peter Stärkel, Clara Belzer, Claus Hellerbrand, Hidekazu Tsukamoto, Samuel B. Ho, Bernd Schnabl – 13 February 2013 – The intestinal mucus layer protects the epithelium from noxious agents, viruses, and pathogenic bacteria present in the gastrointestinal tract. It is composed of mucins, predominantly mucin (Muc) 2, secreted by goblet cells of the intestine.