Randomized trial of emtricitabine/tenofovir disoproxil fumarate after hepatitis B immunoglobulin withdrawal after liver transplantation

Lewis W. Teperman, Fred Poordad, Natalie Bzowej, Paul Martin, Surakit Pungpapong, Thomas Schiano, John Flaherty, Phillip Dinh, Stephen Rossi, G. Mani Subramanian, James Spivey – 27 February 2013 – Long‐term prophylaxis with hepatitis B immunoglobulin (HBIG) for the prevention of hepatitis B virus (HBV) recurrence after orthotopic liver transplantation (OLT) in patients with chronic HBV infection is inconvenient and costly.

Offer patterns of nationally placed livers by donation service area

Jennifer C. Lai, Sandy Feng, Eric Vittinghoff, John P. Roberts – 27 February 2013 – We previously reported that national liver distribution is highly concentrated in 6 US centers, and this raises the possibility of expedited placement. Therefore, we evaluated all national offers of nationally placed livers (n=1625) to adult wait‐list candidates from February 2005 to January 2010. We developed a model to predict national utilization pathways; pathways exceeding the best‐fit linear unbiased predictions by ≥3 standard errors were defined as preferred.

Frequency of the cholesteryl ester storage disease common LIPA E8SJM mutation (c.894G>A) in various racial and ethnic groups

Stuart A. Scott, Benny Liu, Irina Nazarenko, Suparna Martis, Julia Kozlitina, Yao Yang, Charina Ramirez, Yumi Kasai, Tommy Hyatt, Inga Peter, Robert J. Desnick – 19 February 2013 – Cholesteryl ester storage disease (CESD) and Wolman disease are autosomal recessive later‐onset and severe infantile disorders, respectively, which result from the deficient activity of lysosomal acid lipase (LAL). LAL is encoded by LIPA (10q23.31) and the most common mutation associated with CESD is an exon 8 splice junction mutation (c.894G>A; E8SJM), which expresses only ∼3%‐5% of normally spliced LAL.

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