Liver fatty acid binding protein (L‐Fabp) modulates murine stellate cell activation and diet‐induced nonalcoholic fatty liver disease

Anping Chen, Youcai Tang, Victoria Davis, Fong‐Fu Hsu, Susan M. Kennedy, Haowei Song, John Turk, Elizabeth M. Brunt, Elizabeth P. Newberry, Nicholas O. Davidson – 11 February 2013 – Activation of hepatic stellate cells (HSCs) is crucial to the development of fibrosis in nonalcoholic fatty liver disease. Quiescent HSCs contain lipid droplets (LDs), whose depletion upon activation induces a fibrogenic gene program.

Embolization of large spontaneous portosystemic shunts for refractory hepatic encephalopathy: A multicenter survey on safety and efficacy

Wim Laleman, Macarena Simon‐Talero, Geert Maleux, Mercedes Perez, Koen Ameloot, German Soriano, Jordi Villalba, Juan‐Carlos Garcia‐Pagan, Marta Barrufet, Rajiv Jalan, Jocelyn Brookes, Evangelos Thalassinos, Andrew K. Burroughs, Juan Cordoba, Frederik Nevens, on behalf of the EASL‐CLIF‐Consortium – 7 February 2013 – Refractory hepatic encephalopathy (HE) remains a major cause of morbidity in cirrhosis patients. Large spontaneous portosystemic shunts (SPSSs) have been previously suggested to sustain HE in these patients.

The impact of timing and prioritization on the cost‐effectiveness of birth cohort testing and treatment for hepatitis C virus in the United States

Phil McEwan, Thomas Ward, Yong Yuan, Ray Kim, Gilbert L'Italien – 6 February 2013 – Recent United States guidelines recommend one‐time birth cohort testing for hepatitis C infection in persons born between 1945 and 1965; this represents a major public health policy undertaking. The purpose of this study was to assess the role of treatment timing and prioritization on predicted cost‐effectiveness.

GABA induces the differentiation of small into large cholangiocytes by activation of Ca2+/CaMK I‐dependent adenylyl cyclase 8

Romina Mancinelli, Antonio Franchitto, Shannon Glaser, Fanyin Meng, Paolo Onori, Sharon DeMorrow, Heather Francis, Julie Venter, Guido Carpino, Kimberley Baker, Yuyan Han, Yoshiyuki Ueno, Eugenio Gaudio, Gianfranco Alpini – 6 February 2013 – Large, but not small, cholangiocytes (1) secrete bicarbonate by interaction with secretin receptors (SRs) through activation of cystic fibrosis transmembrane regulator (CFTR), Cl−/HCO3− (apex) anion exchanger 2 (Cl−/HCO3− AE2), and adenylyl cyclase (AC)8 (proteins regulating large biliary functions) and (2) proliferate in response to bile duct ligation

The Stroop smartphone application is a short and valid method to screen for minimal hepatic encephalopathy

Jasmohan S. Bajaj, Leroy R. Thacker, Douglas M. Heuman, Michael Fuchs, Richard K. Sterling, Arun J. Sanyal, Puneet Puri, Mohammad S. Siddiqui, Richard T. Stravitz, Iliana Bouneva, Velimir Luketic, Nicole Noble, Melanie B. White, Pamela Monteith, Ariel Unser, James B. Wade – 6 February 2013 – Minimal hepatic encephalopathy (MHE) detection is difficult because of the unavailability of short screening tools. Therefore, MHE patients can remain undiagnosed and untreated. The aim of this study was to use a Stroop smartphone application (app) (EncephalApp_Stroop) to screen for MHE.

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