MicroRNA‐140‐5p suppresses tumor growth and metastasis by targeting transforming growth factor β receptor 1 and fibroblast growth factor 9 in hepatocellular carcinoma

Hao Yang, Feng Fang, Ruimin Chang, Lianyue Yang – 11 February 2013 – By comparing the expression profiles of microRNAs (miRNAs) in different hepatocellular carcinoma (HCC) subtypes, we identified miR‐140‐5p as an HCC‐related miRNA. We found that miR‐140‐5p was significantly decreased in HCC tissues and all of six liver cancer cell lines examined and its expression levels were correlated with multiple nodules, vein invasion, capsular formation, and differentiation, as well as overall and disease‐free survival of HCC.

Scavenger receptor BI and ABCG5/G8 differentially impact biliary sterol secretion and reverse cholesterol transport in mice

Arne Dikkers, Jan Freak de Boer, Wijtske Annema, Albert K. Groen, Uwe J.F. Tietge – 11 February 2013 – Biliary lipid secretion plays an important role in gallstone disease and reverse cholesterol transport (RCT). Using Sr‐bI/Abcg5 double knockout mice (dko), the present study investigated the differential contribution of two of the most relevant transporters: adenosine triphosphate (ATP)‐binding cassette subfamily G member 5 and 8 (ABCG5/G8) and scavenger receptor class B type I (SR‐BI) to sterol metabolism and RCT.

Liver fatty acid binding protein (L‐Fabp) modulates murine stellate cell activation and diet‐induced nonalcoholic fatty liver disease

Anping Chen, Youcai Tang, Victoria Davis, Fong‐Fu Hsu, Susan M. Kennedy, Haowei Song, John Turk, Elizabeth M. Brunt, Elizabeth P. Newberry, Nicholas O. Davidson – 11 February 2013 – Activation of hepatic stellate cells (HSCs) is crucial to the development of fibrosis in nonalcoholic fatty liver disease. Quiescent HSCs contain lipid droplets (LDs), whose depletion upon activation induces a fibrogenic gene program.

Embolization of large spontaneous portosystemic shunts for refractory hepatic encephalopathy: A multicenter survey on safety and efficacy

Wim Laleman, Macarena Simon‐Talero, Geert Maleux, Mercedes Perez, Koen Ameloot, German Soriano, Jordi Villalba, Juan‐Carlos Garcia‐Pagan, Marta Barrufet, Rajiv Jalan, Jocelyn Brookes, Evangelos Thalassinos, Andrew K. Burroughs, Juan Cordoba, Frederik Nevens, on behalf of the EASL‐CLIF‐Consortium – 7 February 2013 – Refractory hepatic encephalopathy (HE) remains a major cause of morbidity in cirrhosis patients. Large spontaneous portosystemic shunts (SPSSs) have been previously suggested to sustain HE in these patients.

The impact of timing and prioritization on the cost‐effectiveness of birth cohort testing and treatment for hepatitis C virus in the United States

Phil McEwan, Thomas Ward, Yong Yuan, Ray Kim, Gilbert L'Italien – 6 February 2013 – Recent United States guidelines recommend one‐time birth cohort testing for hepatitis C infection in persons born between 1945 and 1965; this represents a major public health policy undertaking. The purpose of this study was to assess the role of treatment timing and prioritization on predicted cost‐effectiveness.

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