Taurolithocholate‐induced MRP2 retrieval involves MARCKS phosphorylation by protein kinase Cϵ in HUH‐NTCP Cells

Christopher M. Schonhoff, Cynthia R. L. Webster, M. Sawkat Anwer – 19 February 2013 – Taurolithocholate (TLC) acutely inhibits the biliary excretion of multidrug‐resistant associated protein 2 (Mrp2) substrates by inducing Mrp2 retrieval from the canalicular membrane, whereas cyclic adenosine monophosphate (cAMP) increases plasma membrane (PM)–MRP2. The effect of TLC may be mediated via protein kinase Cϵ (PKCϵ). Myristoylated alanine‐rich C kinase substrate (MARCKS) is a membrane‐bound F‐actin crosslinking protein and is phosphorylated by PKCs.

Interstrain differences in chronic hepatitis and tumor development in a murine model of inflammation‐mediated hepatocarcinogenesis

Tamara Potikha, Evgeniy Stoyanov, Orit Pappo, Antonina Frolov, Lina Mizrahi, Deborah Olam, Temima Shnitzer‐Perlman, Ido Weiss, Neta Barashi, Amnon Peled, Gabriele Sass, Gisa Tiegs, Francoise Poirier, Gabriel A. Rabinovich, Eithan Galun, Daniel Goldenberg – 19 February 2013 – Chronic inflammation is strongly associated with an increased risk for hepatocellular carcinoma (HCC) development.

Alcohol dehydrogenase–specific T‐cell responses are associated with alcohol consumption in patients with alcohol‐related cirrhosis

Fang Lin, Nicholas J. Taylor, Haibin Su, Xiaohong Huang, Munther J. Hussain, Robin Daniel Abeles, Laura Blackmore, Yunyun Zhou, Mohammad Mashfick Ikbal, Nigel Heaton, Wayel Jassem, Debbie L. Shawcross, Diego Vergani, Yun Ma – 19 February 2013 – Patients with alcohol‐related liver disease (ALD) have antibodies directed to alcohol dehydrogenase (ADH), anti‐ADH titers being associated with disease severity and active alcohol consumption. ADH‐specific T‐cell responses have not been characterized.

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