Prospective Evaluation of Single‐Operator Peroral Cholangioscopy in Liver Transplant Recipients Requiring an Evaluation of the Biliary Tract

Domingo Balderramo, Oriol Sendino, Rosa Miquel, Cristina Rodriguez de Miguel, Josep M. Bordas, Graciela Martinez‐Palli, Maria L. Leoz, Antoni Rimola, Miguel Navasa, Josep Llach, Andrés Cardenas – 12 February 2013 – In this descriptive study, we examined the role of single‐operator cholangioscopy (SOC) in the evaluation of biliary complications after liver transplantation (LT). We prospectively included adult recipients of deceased donor LT who were referred for endoscopic retrograde cholangiopancreatography between June 2009 and July 2011.

Liver fatty acid binding protein (L‐Fabp) modulates murine stellate cell activation and diet‐induced nonalcoholic fatty liver disease

Anping Chen, Youcai Tang, Victoria Davis, Fong‐Fu Hsu, Susan M. Kennedy, Haowei Song, John Turk, Elizabeth M. Brunt, Elizabeth P. Newberry, Nicholas O. Davidson – 11 February 2013 – Activation of hepatic stellate cells (HSCs) is crucial to the development of fibrosis in nonalcoholic fatty liver disease. Quiescent HSCs contain lipid droplets (LDs), whose depletion upon activation induces a fibrogenic gene program.

Scavenger receptor BI and ABCG5/G8 differentially impact biliary sterol secretion and reverse cholesterol transport in mice

Arne Dikkers, Jan Freak de Boer, Wijtske Annema, Albert K. Groen, Uwe J.F. Tietge – 11 February 2013 – Biliary lipid secretion plays an important role in gallstone disease and reverse cholesterol transport (RCT). Using Sr‐bI/Abcg5 double knockout mice (dko), the present study investigated the differential contribution of two of the most relevant transporters: adenosine triphosphate (ATP)‐binding cassette subfamily G member 5 and 8 (ABCG5/G8) and scavenger receptor class B type I (SR‐BI) to sterol metabolism and RCT.

MicroRNA‐140‐5p suppresses tumor growth and metastasis by targeting transforming growth factor β receptor 1 and fibroblast growth factor 9 in hepatocellular carcinoma

Hao Yang, Feng Fang, Ruimin Chang, Lianyue Yang – 11 February 2013 – By comparing the expression profiles of microRNAs (miRNAs) in different hepatocellular carcinoma (HCC) subtypes, we identified miR‐140‐5p as an HCC‐related miRNA. We found that miR‐140‐5p was significantly decreased in HCC tissues and all of six liver cancer cell lines examined and its expression levels were correlated with multiple nodules, vein invasion, capsular formation, and differentiation, as well as overall and disease‐free survival of HCC.

Embolization of large spontaneous portosystemic shunts for refractory hepatic encephalopathy: A multicenter survey on safety and efficacy

Wim Laleman, Macarena Simon‐Talero, Geert Maleux, Mercedes Perez, Koen Ameloot, German Soriano, Jordi Villalba, Juan‐Carlos Garcia‐Pagan, Marta Barrufet, Rajiv Jalan, Jocelyn Brookes, Evangelos Thalassinos, Andrew K. Burroughs, Juan Cordoba, Frederik Nevens, on behalf of the EASL‐CLIF‐Consortium – 7 February 2013 – Refractory hepatic encephalopathy (HE) remains a major cause of morbidity in cirrhosis patients. Large spontaneous portosystemic shunts (SPSSs) have been previously suggested to sustain HE in these patients.

MicroRNA‐26a suppresses tumor growth and metastasis of human hepatocellular carcinoma by targeting interleukin‐6‐Stat3 pathway

Xin Yang, Lei Liang, Xiao‐Fei Zhang, Hu‐Liang Jia, Yi Qin, Xu‐Chao Zhu, Xiao‐Mei Gao, Peng Qiao, Yan Zheng, Yuan‐Yuan Sheng, Jin‐Wang Wei, Hai‐Jun Zhou, Ning Ren, Qing‐Hai Ye, Qiong‐Zhu Dong, Lun‐Xiu Qin – 6 February 2013 – Down‐regulation of microRNA‐26a (miR‐26a) is associated with poor prognosis of hepatocellular carcinoma (HCC), but its functional mechanism in HCC remains unclear. In this study, we investigated the roles of miR‐26a in tumor growth and metastasis of HCC and found that miR‐26a was frequently down‐regulated in HCC tissues.

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