Scavenger receptor BI and ABCG5/G8 differentially impact biliary sterol secretion and reverse cholesterol transport in mice

Arne Dikkers, Jan Freak de Boer, Wijtske Annema, Albert K. Groen, Uwe J.F. Tietge – 11 February 2013 – Biliary lipid secretion plays an important role in gallstone disease and reverse cholesterol transport (RCT). Using Sr‐bI/Abcg5 double knockout mice (dko), the present study investigated the differential contribution of two of the most relevant transporters: adenosine triphosphate (ATP)‐binding cassette subfamily G member 5 and 8 (ABCG5/G8) and scavenger receptor class B type I (SR‐BI) to sterol metabolism and RCT.

MicroRNA‐140‐5p suppresses tumor growth and metastasis by targeting transforming growth factor β receptor 1 and fibroblast growth factor 9 in hepatocellular carcinoma

Hao Yang, Feng Fang, Ruimin Chang, Lianyue Yang – 11 February 2013 – By comparing the expression profiles of microRNAs (miRNAs) in different hepatocellular carcinoma (HCC) subtypes, we identified miR‐140‐5p as an HCC‐related miRNA. We found that miR‐140‐5p was significantly decreased in HCC tissues and all of six liver cancer cell lines examined and its expression levels were correlated with multiple nodules, vein invasion, capsular formation, and differentiation, as well as overall and disease‐free survival of HCC.

Embolization of large spontaneous portosystemic shunts for refractory hepatic encephalopathy: A multicenter survey on safety and efficacy

Wim Laleman, Macarena Simon‐Talero, Geert Maleux, Mercedes Perez, Koen Ameloot, German Soriano, Jordi Villalba, Juan‐Carlos Garcia‐Pagan, Marta Barrufet, Rajiv Jalan, Jocelyn Brookes, Evangelos Thalassinos, Andrew K. Burroughs, Juan Cordoba, Frederik Nevens, on behalf of the EASL‐CLIF‐Consortium – 7 February 2013 – Refractory hepatic encephalopathy (HE) remains a major cause of morbidity in cirrhosis patients. Large spontaneous portosystemic shunts (SPSSs) have been previously suggested to sustain HE in these patients.

MicroRNA‐26a suppresses tumor growth and metastasis of human hepatocellular carcinoma by targeting interleukin‐6‐Stat3 pathway

Xin Yang, Lei Liang, Xiao‐Fei Zhang, Hu‐Liang Jia, Yi Qin, Xu‐Chao Zhu, Xiao‐Mei Gao, Peng Qiao, Yan Zheng, Yuan‐Yuan Sheng, Jin‐Wang Wei, Hai‐Jun Zhou, Ning Ren, Qing‐Hai Ye, Qiong‐Zhu Dong, Lun‐Xiu Qin – 6 February 2013 – Down‐regulation of microRNA‐26a (miR‐26a) is associated with poor prognosis of hepatocellular carcinoma (HCC), but its functional mechanism in HCC remains unclear. In this study, we investigated the roles of miR‐26a in tumor growth and metastasis of HCC and found that miR‐26a was frequently down‐regulated in HCC tissues.

Up‐regulation of circulating miR‐20a is correlated with hepatitis C virus‐mediated liver disease progression

Shubham Shrivastava, Jessica Petrone, Robert Steele, Georg M. Lauer, Adrian M. Bisceglie, Ratna B. Ray – 6 February 2013 – Chronic hepatitis C virus (HCV) infection is one of the major causes of liver fibrosis and liver transplantation in the United States. Circulating microRNAs (miRNAs) in the blood are emerging as biomarkers for pathological conditions. In the present study we performed a systematic screening approach to identify up‐regulated miRNAs in the plasma/serum of HCV‐infected patients with different stages of hepatic histological disease severity.

Dietary fructose in nonalcoholic fatty liver disease

Miriam B. Vos, Joel E. Lavine – 6 February 2013 – Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in adults and children. A number of genetic and environmental factors are known to predispose individuals to NAFLD. Certain dietary sugars, particularly fructose, are suspected to contribute to the development of NAFLD and its progression. The increasing quantity of fructose in the diet comes from sugar additives (most commonly sucrose and high fructose corn syrup) in beverages and processed foods.

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