Claudia A. Couto, Paulo L. Bittencourt, Gilda Porta, Clarice P. Abrantes‐Lemos, Flair J. Carrilho, Bianca D. Guardia, Eduardo L.R. Cançado – 8 August 2013 – Reactivity and titers of autoantibodies vary during the course of autoimmune hepatitis (AIH), and some autoantibodies have been associated with disease activity and adverse outcomes after treatment. The aim of this study was to assess the autoantibody behavior in AIH and its significance as predictors of biochemical and histological remission.

Jason Grebely, Bart Grady, Behzad Hajarizadeh, Kimberly Page, Gregory J. Dore, On Behalf of the INC Study Group – 8 August 2013

Yi Zhang, Wei Cai, Qingrong Huang, Yuting Gu, Yufang Shi, Jiefang Huang, Fang Zhao, Qiang Liu, Xunbin Wei, Min Jin, Changping Wu, Qing Xie, Yi Zhang, Bing Wan, Yanyun Zhang – 8 August 2013 – Fulminant hepatic failure (FHF) is a clinical syndrome characterized by sudden and severe impairment of liver function. Mesenchymal stem cells (MSCs) have been proposed as a promising therapeutic approach for FHF. In this study we used Propionibacterium acnes (P. acnes)‐primed, lipopolysaccharide (LPS)‐induced liver injury in mice as an animal model of human FHF.

Wajahat Z. Mehal – 8 August 2013

Anne Robins, Anne Bowden, William Watson, Fiona Smith, William Gelson, William Griffiths – 8 August 2013

Alberto Q. Farias, Odilson M. Silvestre, Guadalupe Garcia‐Tsao, Luis F.B. Seguro, Daniel F. Mazo, Fernando Bacal, José L. Andrade, Luciana L. Gonçalves, Célia Strunz, Danusa S. Ramos, Demerson Polli, Vincenzo Pugliese, Ana C.T. Rodrigues, Meive S. Furtado, Flair J. Carrilho, Luiz A.C. D'Albuquerque – 2 August 2013 – Heart failure (HF) is, after cirrhosis, the second‐most common cause of ascites. Serum B‐type natriuretic peptide (BNP) plays an important role in the diagnosis of HF. Therefore, we hypothesized that BNP would be useful in the differential diagnosis of ascites.

Szun S. Tay, Bo Lu, Fred Sierro, Volker Benseler, Claire M. McGuffog, G. Alex Bishop, Peter J. Cowan, Geoffrey W. McCaughan, Karen M. Dwyer, David G. Bowen, Patrick Bertolino – 2 August 2013 – Donor passenger leukocytes (PLs) from transplanted livers migrate to recipient lymphoid tissues, where they are thought to induce the deletion of donor‐specific T cells and tolerance.

Jason Grebely, Kimberly Page, Rachel Sacks‐Davis, Maarten Schim Loeff, Thomas M. Rice, Julie Bruneau, Meghan D. Morris, Behzad Hajarizadeh, Janaki Amin, Andrea L. Cox, Arthur Y. Kim, Barbara H. McGovern, Janke Schinkel, Jacob George, Naglaa H. Shoukry, Georg M. Lauer, Lisa Maher, Andrew R. Lloyd, Margaret Hellard, Gregory J. Dore, Maria Prins, the InC3 Study Group – 2 August 2013 – Although 20%‐40% of persons with acute hepatitis C virus (HCV) infection demonstrate spontaneous clearance, the time course and factors associated with clearance remain poorly understood.

Santseharay Ramirez, Yi‐Ping Li, Sanne B. Jensen, Jannie Pedersen, Judith M. Gottwein, Jens Bukh – 2 August 2013 – Hepatitis C virus (HCV) is a genetically diverse virus with multiple genotypes exhibiting remarkable differences, particularly in drug susceptibility. Drug and vaccine development will benefit from high‐titer HCV cultures mimicking the complete viral life cycle, but such systems only exist for genotypes 1a and 2a. We developed efficient culture systems for the epidemiologically important genotype 2b.

Lionel Lim, Asha Balakrishnan, Noelle Huskey, Kirk D. Jones, Mona Jodari, Raymond Ng, Guisheng Song, Jesse Riordan, Brittany Anderton, Siu‐Tim Cheung, Holger Willenbring, Adam Dupuy, Xin Chen, David Brown, Aaron N. Chang, Andrei Goga – 2 August 2013 – Hepatocellular carcinoma (HCC) is associated with poor survival for patients and few effective treatment options, raising the need for novel therapeutic strategies. MicroRNAs (miRNAs) play important roles in tumor development and show deregulated patterns of expression in HCC.