Sorafenib perpetuates cellular anticancer effector functions by modulating the crosstalk between macrophages and natural killer cells

Martin Franz Sprinzl, Florian Reisinger, Andreas Puschnik, Marc Ringelhan, Kerstin Ackermann, Daniel Hartmann, Matthias Schiemann, Arndt Weinmann, Peter Robert Galle, Marcus Schuchmann, Helmut Friess, Gerd Otto, Mathias Heikenwalder, Ulrike Protzer – 19 February 2013 – Alternatively polarized macrophages (Mϕ) shape the microenvironment of hepatocellular carcinoma (HCC) and temper anticancer immune responses. We investigated if sorafenib alters the HCC microenvironment by restoring classical macrophage polarization and triggering tumor‐directed natural killer (NK) cell responses.

Albumin: Pathophysiologic basis of its role in the treatment of cirrhosis and its complications

Rita Garcia‐Martinez, Paolo Caraceni, Mauro Bernardi, Pere Gines, Vicente Arroyo, Rajiv Jalan – 19 February 2013 – Since the introduction of human serum albumin as a plasma expander in the 1940s, considerable research has allowed a better understanding of its biochemical properties and potential clinical benefits. Albumin has a complex structure, which is responsible for a variety of biological functions. In disease, the albumin molecule is susceptible to modifications that may alter its biological activity.

Albumin: Pathophysiologic basis of its role in the treatment of cirrhosis and its complications

Rita Garcia‐Martinez, Paolo Caraceni, Mauro Bernardi, Pere Gines, Vicente Arroyo, Rajiv Jalan – 19 February 2013 – Since the introduction of human serum albumin as a plasma expander in the 1940s, considerable research has allowed a better understanding of its biochemical properties and potential clinical benefits. Albumin has a complex structure, which is responsible for a variety of biological functions. In disease, the albumin molecule is susceptible to modifications that may alter its biological activity.

Alcohol dehydrogenase–specific T‐cell responses are associated with alcohol consumption in patients with alcohol‐related cirrhosis

Fang Lin, Nicholas J. Taylor, Haibin Su, Xiaohong Huang, Munther J. Hussain, Robin Daniel Abeles, Laura Blackmore, Yunyun Zhou, Mohammad Mashfick Ikbal, Nigel Heaton, Wayel Jassem, Debbie L. Shawcross, Diego Vergani, Yun Ma – 19 February 2013 – Patients with alcohol‐related liver disease (ALD) have antibodies directed to alcohol dehydrogenase (ADH), anti‐ADH titers being associated with disease severity and active alcohol consumption. ADH‐specific T‐cell responses have not been characterized.

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