Jiesi Xu, Yuanyuan Li, Wei‐Dong Chen, Yang Xu, Liya Yin, Xuemei Ge, Kavita Jadhav, Luciano Adorini, Yanqiao Zhang – 28 August 2013 – Nonalcoholic fatty liver disease (NAFLD) is one of the major health concerns worldwide. Farnesoid X receptor (FXR) is considered a therapeutic target for treatment of NAFLD. However, the mechanism by which activation of FXR lowers hepatic triglyceride (TG) levels remains unknown. Here we investigated the role of hepatic carboxylesterase 1 (CES1) in regulating both normal and FXR‐controlled lipid homeostasis.

Bo Wang, Shu‐hao Hsu, Xinmei Wang, Huban Kutay, Hemant Kumar Bid, Jianhua Yu, Ramesh K. Ganju, Samson T. Jacob, Mariia Yuneva, Kalpana Ghoshal – 28 August 2013 – c‐Myc is a well‐known oncogene frequently up‐regulated in different malignancies, whereas liver‐specific microRNA (miR)‐122, a bona fide tumor suppressor, is down‐regulated in hepatocellular cancer (HCC). Here we explored the underlying mechanism of reciprocal regulation of these two genes.

Wahiba Berrabah, Pierrette Aumercier, Céline Gheeraert, Hélène Dehondt, Emmanuel Bouchaert, Jérémy Alexandre, Maheul Ploton, Claire Mazuy, Sandrine Caron, Anne Tailleux, Jérôme Eeckhoute, Tony Lefebvre, Bart Staels, Philippe Lefebvre – 28 August 2013 – Bile acid metabolism is intimately linked to the control of energy homeostasis and glucose and lipid metabolism. The nuclear receptor farnesoid X receptor (FXR) plays a major role in the enterohepatic cycling of bile acids, but the impact of nutrients on bile acid homeostasis is poorly characterized.

Klaas Poelstra – 28 August 2013

David S. Goldberg, George Makar, Therese Bittermann, Benjamin French – 27 August 2013 – The Model for End‐Stage Liver Disease (MELD) score is an imperfect prognosticator of waitlist dropout, so transplant centers may apply for exception points to increase a waitlist candidate's priority on the waitlist. Exception applications are categorized as recognized exceptional diagnoses (REDs; eg, hepatocellular carcinoma) and non‐REDs (eg, cholangitis). Although prior work has demonstrated regional variation in the use of exceptions, no work has examined the between‐center variability.

Andres Duarte‐Rojo, Vikram Budhraja, Bart J. Veldt, David D. Goldstein, Kymberly D. Watt, Julie K. Heimbach, John G. McHutchison, Hans L. Tillman, John J. Poterucha, Michael R. Charlton – 27 August 2013 – Chronic hepatitis C (CHC)–related cirrhosis is the leading indication for liver transplantation (LT). However, the recurrence of a hepatitis C virus (HCV) infection after transplantation is universal and is associated with worse outcomes.

Mettu Srinivas Reddy, Gomathy Narasimhan, Pradeep Thomas Cherian, Mohamed Rela – 27 August 2013

Abdl‐Rawf Al‐Nowaylati, Benjamin J. S. Al‐Haddad, Rob B. Dorman, Osama A. Alsaied, John R. Lake, Srinath Chinnakotla, Bridget M. Slusarek, Barbara K. Sampson, Sayeed Ikramuddin, Henry Buchwald, Daniel B. Leslie – 27 August 2013 – Few data are available for assessing the outcomes of bariatric surgery for patients who have undergone orthotopic liver transplantation (OLT).

Mariya L. Samoylova, Jennifer L. Dodge, Eric Vittinghoff, Francis Y. Yao, John Paul Roberts – 27 August 2013 – The Organ Procurement and Transplantation Network (OPTN)/United Network for Organ Sharing (UNOS) database is the most comprehensive collection of liver transplantation data, but the quality of these data with respect to hepatocellular carcinoma (HCC) recurrence has not been well assessed.

Seong Chul Kim, Chun‐Ki Kim, David Axe, Aaron Cook, Mikang Lee, Tiangang Li, Nicole Smallwood, John Y.L. Chiang, James P. Hardwick, David D. Moore, Yoon Kwang Lee – 26 August 2013