Randomized trial of emtricitabine/tenofovir disoproxil fumarate after hepatitis B immunoglobulin withdrawal after liver transplantation

Lewis W. Teperman, Fred Poordad, Natalie Bzowej, Paul Martin, Surakit Pungpapong, Thomas Schiano, John Flaherty, Phillip Dinh, Stephen Rossi, G. Mani Subramanian, James Spivey – 27 February 2013 – Long‐term prophylaxis with hepatitis B immunoglobulin (HBIG) for the prevention of hepatitis B virus (HBV) recurrence after orthotopic liver transplantation (OLT) in patients with chronic HBV infection is inconvenient and costly.

Technical aspects and outcomes of living donor liver transplantation for pediatric patients with situs inversus

Rodrigo Vincenzi, Joao Seda‐Neto, Eduardo Antunes da Fonseca, Bernardo Mazzini Ketzer, Marcel Benavides, Helry Lopes Cândido, Gilda Porta, Irene Kazue Miura, Renata Pugliese, Vera Baggio Danesi, Teresa Cristina Guimaraes, Adriana Porta, Cristian Barbieri Borges, Mario Kondo, Paulo Chapchap – 27 February 2013 – The vascular anomalies encountered in patients with biliary atresia associated with polysplenia syndrome and situs inversus (SI) demand technical refinements when liver transplantation is being performed.

Erythrocytosis after liver transplantation: The experience of a university hospital

Gabriella Cordone, Fabiana Zingone, Giuseppe Cardillo, Vincenzo Martinelli, Novella Pugliese, Lucienne Pellegrini, Carolina Ciacci, Gianpaolo Parrilli – 27 February 2013 – The prevalence and causes of erythrocytosis after liver transplantation have never been studied, even though this condition is known to predispose patients to thrombosis leading to graft failure or death. Erythrocytosis after orthotopic liver transplantation (OLT) can be defined as an increase in the red cell mass >125% in patients without a pre‐OLT history of this condition.

Combination of lamivudine and adefovir without hepatitis B immune globulin is safe and effective prophylaxis against hepatitis B virus recurrence in hepatitis B surface antigen–positive liver transplant candidates

Edward J. Gane, Scott Patterson, Simone I. Strasser, Geoffrey W. McCaughan, Peter W. Angus – 27 February 2013 – Without effective prophylaxis, liver transplantation for hepatitis B virus (HBV)–related liver disease is frequently complicated by severe and rapidly progressive HBV recurrence. Combination prophylaxis with hepatitis B immune globulin (HBIG) and lamivudine (LAM) reduces long‐term recurrence rates below 10%; however, HBIG is costly and inconvenient to administer.

Therapeutic recovery of hepatitis B virus (HBV)‐induced hepatocyte‐intrinsic immune defect reverses systemic adaptive immune tolerance

Peixiang Lan, Cai Zhang, Qiuju Han, Jian Zhang, Zhigang Tian – 27 February 2013 – Hepatitis B virus (HBV) persistence aggravates hepatic immunotolerance, leading to the failure of cell‐intrinsic type I interferon and antiviral response, but whether and how HBV‐induced hepatocyte‐intrinsic tolerance influences systemic adaptive immunity has never been reported, which is becoming the major obstacle for chronic HBV therapy.

Director of anesthesiology for liver transplantation: Existing practices and recommendations by the united network for organ sharing

M. Susan Mandell, Elizabeth A. Pomfret, Randall Steadman, Ryutaro Hirose, David J. Reich, Roman Schumann, Ann Walia – 27 February 2013 – A new Organ Procurement and Transplantation Network/United Network for Organ Sharing bylaw recommends that all centers appoint a director of liver transplant anesthesia with a uniform set of criteria. We obtained survey data from the Liver Transplant Anesthesia Consortium so that we could compare existing criteria for a director in the United States with the current recommendations.

Treatment strategy for recurrent hepatocellular carcinoma: Salvage transplantation, repeated resection, or radiofrequency ablation?

Albert C. Y. Chan, See Ching Chan, Kenneth S. H. Chok, Tan To Cheung, Dai Wing Chiu, Ronnie T. P. Poon, Sheung Tat Fan, Chung Mau Lo – 27 February 2013 – The objective of this study was to evaluate the efficacy of salvage liver transplantation (SLT), repeated hepatic resection (RR), and repeated radiofrequency ablation (rRFA) for patients with postoperative tumor recurrence. The optimal treatment strategy for patients with recurrent hepatocellular carcinoma (HCC) remains unclear.

Liver stiffness is influenced by a standardized meal in patients with chronic hepatitis C virus at different stages of fibrotic evolution

Umberto Arena, Monica Lupsor Platon, Cristina Stasi, Stefania Moscarella, Alì Assarat, Giorgio Bedogni, Valeria Piazzolla, Radu Badea, Giacomo Laffi, Fabio Marra, Alessandra Mangia, Massimo Pinzani – 27 February 2013 – Transient elastography (TE) is increasingly employed in clinical practice for the noninvasive detection of tissue fibrosis in patients with chronic liver disease (CLD), and particularly chronic hepatitis C virus (HCV)‐related hepatitis.

Subscribe to