SOX1 functions as a tumor suppressor by antagonizing the WNT/β‐catenin signaling pathway in hepatocellular carcinoma

Chun‐Ming Tsao, Ming‐De Yan, Yu‐Lueng Shih, Pei‐Ning Yu, Chih‐Chi Kuo, Wen‐Chi Lin, Hsin‐Jung Li, Ya‐Wen Lin – 5 July 2012 – Oncogenic activation of the Wnt/β‐catenin signaling pathway is common in hepatocellular carcinoma (HCC). Our recent studies have demonstrated that SRY (sex determining region Y)‐box 1 (SOX1) and secreted frizzled‐related proteins are concomitantly promoter‐hypermethylated, and this might lead to abnormal activation of the Wnt signaling pathway in HCC. SOX1 encodes a transcription factor involved in the regulation of embryonic development and cell fate determination.

Elovl6 promotes nonalcoholic steatohepatitis

Takashi Matsuzaka, Ayaka Atsumi, Rie Matsumori, Tang Nie, Haruna Shinozaki, Noriko Suzuki‐Kemuriyama, Motoko Kuba, Yoshimi Nakagawa, Kiyoaki Ishii, Masako Shimada, Kazuto Kobayashi, Shigeru Yatoh, Akimitsu Takahashi, Kazuhiro Takekoshi, Hirohito Sone, Naoya Yahagi, Hiroaki Suzuki, Soichiro Murata, Makoto Nakamuta, Nobuhiro Yamada, Hitoshi Shimano – 30 June 2012 – Nonalcoholic steatohepatitis (NASH) is associated with obesity and type 2 diabetes, and an increased risk for liver cirrhosis and cancer.

Antimicrobial therapeutic determinants of outcomes from septic shock among patients with cirrhosis

Yaseen M. Arabi, Saqib I. Dara, Ziad Memish, Abdulmajeed Al Abdulkareem, Hani M. Tamim, Nehad Al‐Shirawi, Joseph E. Parrillo, Peter Dodek, Stephen Lapinsky, Daniel Feinstein, Gordon Wood, Sandra Dial, Sergio Zanotti, Anand Kumar, for the Cooperative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group – 30 June 2012 – It is unclear whether practice‐related aspects of antimicrobial therapy contribute to the high mortality from septic shock among patients with cirrhosis.

Liver vitamin D receptor, CYP2R1, and CYP27A1 expression: relationship with liver histology and vitamin D3 levels in patients with nonalcoholic steatohepatitis or hepatitis C virus

Ilaria Barchetta, Simone Carotti, Giancarlo Labbadia, Umberto Vespasiani Gentilucci, Andrea Onetti Muda, Francesco Angelico, Gianfranco Silecchia, Frida Leonetti, Antonio Fraioli, Antonio Picardi, Sergio Morini, Maria Gisella Cavallo – 30 June 2012 – Evidence suggests an association between low serum 25‐hydroxy‐vitamin D3 [25(OH)D3] levels and the presence and prognosis of liver disease. Vitamin D receptor (VDR) has been widely detected in the liver, but its expression in the course of liver disease has never been investigated.

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