Interleukin‐33 Is hepatoprotective during liver ischemia/reperfusion in mice

Nozomu Sakai, Heather L. Van Sweringen, R. Cutler Quillin, Rebecca Schuster, John Blanchard, Justin M. Burns, Amit D. Tevar, Michael J. Edwards, Alex B. Lentsch – 10 July 2012 – Interleukin (IL)‐33 is a recently identified member of the IL‐1 family that binds to the receptor, ST2L. In the current study, we sought to determine whether IL‐33 is an important regulator in the hepatic response to ischemia/reperfusion (I/R). Male C57BL/6 mice were subjected to 90 minutes of partial hepatic ischemia, followed by up to 8 hours of reperfusion.

MicroRNA‐27b is a regulatory hub in lipid metabolism and is altered in dyslipidemia

Kasey C. Vickers, Bassem M. Shoucri, Michael G. Levin, Han Wu, Daniel S. Pearson, David Osei‐Hwedieh, Francis S. Collins, Alan T. Remaley, Praveen Sethupathy – 6 July 2012 – Cellular and plasma lipid levels are tightly controlled by complex gene regulatory mechanisms. Elevated plasma lipid content, or hyperlipidemia, is a significant risk factor for cardiovascular morbidity and mortality.

Accuracy of real‐time shear wave elastography for assessing liver fibrosis in chronic hepatitis C: A pilot study

Giovanna Ferraioli, Carmine Tinelli, Barbara Dal Bello, Mabel Zicchetti, Gaetano Filice, Carlo Filice, on behalf of the Liver Fibrosis Study Group – 5 July 2012 – Real‐time shear wave elastography (SWE) is a novel, noninvasive method to assess liver fibrosis by measuring liver stiffness. This single‐center study was conducted to assess the accuracy of SWE in patients with chronic hepatitis C (CHC), in comparison with transient elastography (TE), by using liver biopsy (LB) as the reference standard. Consecutive patients with CHC scheduled for LB by referring physicians were studied.

Underlying steatohepatitis, but not simple hepatic steatosis, increases morbidity after liver resection: A case‐control study

Srinevas K. Reddy, J. Wallis Marsh, Patrick R. Varley, Brady K. Mock, Kapil B. Chopra, David A. Geller, Allan Tsung – 5 July 2012 – Despite the high prevalence of fatty liver disease, the safety of liver resection in settings of steatohepatitis (SH) or hepatic steatosis is poorly understood. The aim of this study was to determine whether underlying SH or simple hepatic steatosis increases morbidity after liver resection.

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