Preoperative prediction of the microvascular invasion of hepatocellular carcinoma with diffusion‐weighted imaging

Young Joo Suh, Myeong‐Jin Kim, Jin‐Young Choi, Mi‐Suk Park, Ki Whang Kim – 5 July 2012 – The aim of this study was to investigate whether diffusion‐weighted imaging (DWI) could be useful in predicting the microvascular invasion (MVI) of hepatocellular carcinoma (HCC). Sixty‐seven surgically proven HCCs from 65 patients (54 men and 11 women with an age range of 35‐75 years and a mean age of 56.0 years) were retrospectively analyzed.

Inflammatory markers sampled by microdialysis catheters distinguish rejection from ischemia in liver grafts

Håkon Haugaa, Ebbe Billmann Thorgersen, Anne Pharo, Kirsten M. Boberg, Aksel Foss, Pål Dag Line, Truls Sanengen, Runar Almaas, Guro Grindheim, Lars Wælgaard, Soeren Erik Pischke, Tom Eirik Mollnes, Tor Inge Tønnessen – 5 July 2012 – Rejection and ischemia are serious complications after liver transplantation. Early detection is mandatory, but specific markers are largely missing, particularly for rejection.

SOX1 functions as a tumor suppressor by antagonizing the WNT/β‐catenin signaling pathway in hepatocellular carcinoma

Chun‐Ming Tsao, Ming‐De Yan, Yu‐Lueng Shih, Pei‐Ning Yu, Chih‐Chi Kuo, Wen‐Chi Lin, Hsin‐Jung Li, Ya‐Wen Lin – 5 July 2012 – Oncogenic activation of the Wnt/β‐catenin signaling pathway is common in hepatocellular carcinoma (HCC). Our recent studies have demonstrated that SRY (sex determining region Y)‐box 1 (SOX1) and secreted frizzled‐related proteins are concomitantly promoter‐hypermethylated, and this might lead to abnormal activation of the Wnt signaling pathway in HCC. SOX1 encodes a transcription factor involved in the regulation of embryonic development and cell fate determination.

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