Nozomu Sakai, Heather L. Van Sweringen, R. Cutler Quillin, Rebecca Schuster, John Blanchard, Justin M. Burns, Amit D. Tevar, Michael J. Edwards, Alex B. Lentsch – 10 July 2012 – Interleukin (IL)‐33 is a recently identified member of the IL‐1 family that binds to the receptor, ST2L. In the current study, we sought to determine whether IL‐33 is an important regulator in the hepatic response to ischemia/reperfusion (I/R). Male C57BL/6 mice were subjected to 90 minutes of partial hepatic ischemia, followed by up to 8 hours of reperfusion.

Tram T. Tran, Luis H. Ocampo – 6 July 2012

Kasey C. Vickers, Bassem M. Shoucri, Michael G. Levin, Han Wu, Daniel S. Pearson, David Osei‐Hwedieh, Francis S. Collins, Alan T. Remaley, Praveen Sethupathy – 6 July 2012 – Cellular and plasma lipid levels are tightly controlled by complex gene regulatory mechanisms. Elevated plasma lipid content, or hyperlipidemia, is a significant risk factor for cardiovascular morbidity and mortality.

Chun‐Ming Tsao, Ming‐De Yan, Yu‐Lueng Shih, Pei‐Ning Yu, Chih‐Chi Kuo, Wen‐Chi Lin, Hsin‐Jung Li, Ya‐Wen Lin – 5 July 2012 – Oncogenic activation of the Wnt/β‐catenin signaling pathway is common in hepatocellular carcinoma (HCC). Our recent studies have demonstrated that SRY (sex determining region Y)‐box 1 (SOX1) and secreted frizzled‐related proteins are concomitantly promoter‐hypermethylated, and this might lead to abnormal activation of the Wnt signaling pathway in HCC. SOX1 encodes a transcription factor involved in the regulation of embryonic development and cell fate determination.

Håkon Haugaa, Ebbe Billmann Thorgersen, Anne Pharo, Kirsten M. Boberg, Aksel Foss, Pål Dag Line, Truls Sanengen, Runar Almaas, Guro Grindheim, Lars Wælgaard, Soeren Erik Pischke, Tom Eirik Mollnes, Tor Inge Tønnessen – 5 July 2012 – Rejection and ischemia are serious complications after liver transplantation. Early detection is mandatory, but specific markers are largely missing, particularly for rejection.

Young Joo Suh, Myeong‐Jin Kim, Jin‐Young Choi, Mi‐Suk Park, Ki Whang Kim – 5 July 2012 – The aim of this study was to investigate whether diffusion‐weighted imaging (DWI) could be useful in predicting the microvascular invasion (MVI) of hepatocellular carcinoma (HCC). Sixty‐seven surgically proven HCCs from 65 patients (54 men and 11 women with an age range of 35‐75 years and a mean age of 56.0 years) were retrospectively analyzed.

Scott L. Nyberg – 5 July 2012 – Key Points

James V. Guarrera – 5 July 2012 – Key Points

Simon Lessard, Geneviève Soucy, Michel Dagenais, Catherine Vincent – 5 July 2012

Srinevas K. Reddy, J. Wallis Marsh, Patrick R. Varley, Brady K. Mock, Kapil B. Chopra, David A. Geller, Allan Tsung – 5 July 2012 – Despite the high prevalence of fatty liver disease, the safety of liver resection in settings of steatohepatitis (SH) or hepatic steatosis is poorly understood. The aim of this study was to determine whether underlying SH or simple hepatic steatosis increases morbidity after liver resection.