Hepatitis c virus‐specific t‐cell‐derived transforming growth factor beta is associated with slow hepatic fibrogenesis

Shaoyong Li, Lianne E.M. Vriend, Imad A. Nasser, Yury Popov, Nezam H. Afdhal, Margaret J. Koziel, Detlef Schuppan, Mark A. Exley, Nadia Alatrakchi – 14 July 2012 – Hepatitis C virus (HCV)‐specific immune effector responses can cause liver damage in chronic infection. Hepatic stellate cells (HSC) are the main effectors of liver fibrosis. TGFβ, produced by HCV‐specific CD8+ T cells, is a key regulatory cytokine modulating HCV‐specific effector T cells.

Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent

Tomonori Aoyama, Yong‐Han Paik, Sumio Watanabe, Benoît Laleu, Francesca Gaggini, Laetitia Fioraso‐Cartier, Sophie Molango, Freddy Heitz, Cédric Merlot, Cédric Szyndralewiez, Patrick Page, David A. Brenner – 14 July 2012 – Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) generates reactive oxygen species (ROS) in hepatic stellate cells (HSCs) during liver fibrosis. In response to fibrogenic agonists, such as angiotensin II (Ang II), the NOX1 components form an active complex, including Ras‐related botulinum toxin substrate 1 (Rac1).

Complicated relationships of amino acid substitution in hepatitis C virus core region and IL28B genotype influencing hepatocarcinogenesis

Norio Akuta, Fumitaka Suzuki, Yuya Seko, Yusuke Kawamura, Hitomi Sezaki, Yoshiyuki Suzuki, Tetsuya Hosaka, Masahiro Kobayashi, Tasuku Hara, Mariko Kobayashi, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Hiromitsu Kumada – 14 July 2012 – The impact of amino acid (aa) 70 substitution in the core region on hepatocarcinogenesis and survival for liver‐related death in patients of hepatitis C virus (HCV) genotype 1b (HCV‐1b), who had not received antiviral therapy, is unknown. The relationships among aa 70 substitution, IL28B genotype, and hepatocarcinogenesis are also not clear.

Subscribe to