Estrogen‐sensitive PTPRO expression represses hepatocellular carcinoma progression by control of STAT3

Jiajie Hou, Juan Xu, Runqiu Jiang, Youjing Wang, Chen Chen, Lei Deng, Xingxu Huang, Xuehao Wang, Beicheng Sun – 23 July 2012 – Protein tyrosine phosphatase receptor type O (PTPRO), one of the receptor types of phosphotyrosine phosphatases (PTP), was recently described as a tumor suppressor in various kinds of cancers. We aimed to clarify the role of PTPRO in hepatocellular carcinoma (HCC).

High‐mobility group box 1 (HMGB1)‐toll‐like receptor (TLR)4‐interleukin (IL)‐23‐IL‐17A axis in drug‐induced damage‐associated lethal hepatitis: Interaction of γδ T cells with macrophages

Xuefu Wang, Rui Sun, Haiming Wei, Zhigang Tian – 23 July 2012 – Acetaminophen overdose causes acute liver inflammation with neutrophil infiltration; however, the mechanism of damage‐associated inflammation has not been elucidated. In this study we found that the HMGB1‐TLR4‐IL‐23‐IL‐17A axis played a crucial role in acetaminophen‐induced infiltration of neutrophils and liver injury. Notably, interleukin (IL)‐17A and IL‐23 significantly increased after acetaminophen challenge.

Genome‐wide association analysis in Primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4

David Ellinghaus, Trine Folseraas, Kristian Holm, Eva Ellinghaus, Espen Melum, Tobias Balschun, Jon K. Laerdahl, Alexey Shiryaev, Daniel N. Gotthardt, Tobias J. Weismüller, Christoph Schramm, Michael Wittig, Annika Bergquist, Einar Björnsson, Hanns‐Ulrich Marschall, Morten Vatn, Andreas Teufel, Christian Rust, Christian Gieger, H‐Erich Wichmann, Heiko Runz, Martina Sterneck, Christian Rupp, Felix Braun, Rinse K. Weersma, Cisca Wijmenga, Cyriel Y. Ponsioen, Christopher G. Mathew, Paul Rutgeerts, Séverine Vermeire, Erik Schrumpf, Johannes R. Hov, Michael P. Manns, Kirsten M.

Is liver transplantation a risk factor for cardiovascular disease? a meta‐analysis of observational studies

Surabhi Madhwal, Ashish Atreja, Mazen Albeldawdi, Rocio Lopez, Anthony Post, Marco A. Costa – 20 July 2012 – Up to two‐thirds of patients develop metabolic syndrome within the first 5 years after orthotopic liver transplantation (OLT). However, data on overall cardiovascular (CV) morbidity and mortality among OLT recipients and particularly those who develop metabolic syndrome remain elusive.

Long‐term quality of life of donors after living donor liver transplantation

Yasutsugu Takada, Yoshimi Suzukamo, Fumitaka Oike, Hiroto Egawa, Satoshi Morita, Shunichi Fukuhara, Shinji Uemoto, Koichi Tanaka – 20 July 2012 – The aims of this study were to investigate the long‐term effects of living donor liver transplantation (LDLT) on the health‐related quality of life (HRQOL) of donors with the Short Form 36 health survey and to determine the risk factors for poor outcomes. Between June 1990 and June 2004, LDLT was performed 1000 times at Kyoto University Hospital.

TIE2‐expressing monocytes as a diagnostic marker for hepatocellular carcinoma correlates with angiogenesis

Tokuhiro Matsubara, Tatsuya Kanto, Shoko Kuroda, Sachiyo Yoshio, Koyo Higashitani, Naruyasu Kakita, Masanori Miyazaki, Mitsuru Sakakibara, Naoki Hiramatsu, Akinori Kasahara, Yoshito Tomimaru, Akira Tomokuni, Hiroaki Nagano, Norio Hayashi, Tetsuo Takehara – 19 July 2012 – Angiogenesis is a critical step in the development and progression of hepatocellular carcinoma (HCC). Myeloid lineage cells, such as macrophages and monocytes, have been reported to regulate angiogenesis in mouse tumor models.

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