Hepatitis C viral infection in difficult‐to‐treat populations: An overview
Nezam H. Afdhal – 23 July 2012 – Watch a video presentation of this article
Serum C‐reactive protein is a useful biomarker for predicting outcomes after liver transplantation in patients with hepatocellular carcinoma
Ho Jung An, Jeong Won Jang, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon, Myung Ah Lee, Young Kyoung You, Dong Goo Kim, Eun Sun Jung – 23 July 2012 – Liver transplantation (LT) is a curative modality for hepatocellular carcinoma (HCC), especially in patients with cirrhosis. However, there are still risks of recurrence. C‐reactive protein (CRP), an acute‐phase inflammatory reactant that is synthesized by hepatocytes, has been related to the prognosis of various malignancies, including HCC.
Reducing the load: The evolution and management of obesity and nonalcoholic steatohepatitis before liver transplantation
Kymberly D. Watt – 23 July 2012 – Key Points
Hepatitis C genotype 1 infection in HIV–Infected patients in the era of direct‐acting antiviral therapy
Mark S. Sulkowski – 23 July 2012 – Watch the interview with the author
Access to care: Management of hepatitis C viral infection in remote locations
Sanjeev Arora, Karla Thornton, Andrea Bradford – 23 July 2012 – Watch a video presentation of this article
Hepatitis C viral infection in children
Douglas Mogul, Kathleen B. Schwarz – 23 July 2012 – Watch an interview with Dr. Schwarz
Estrogen‐sensitive PTPRO expression represses hepatocellular carcinoma progression by control of STAT3
Jiajie Hou, Juan Xu, Runqiu Jiang, Youjing Wang, Chen Chen, Lei Deng, Xingxu Huang, Xuehao Wang, Beicheng Sun – 23 July 2012 – Protein tyrosine phosphatase receptor type O (PTPRO), one of the receptor types of phosphotyrosine phosphatases (PTP), was recently described as a tumor suppressor in various kinds of cancers. We aimed to clarify the role of PTPRO in hepatocellular carcinoma (HCC).
High‐mobility group box 1 (HMGB1)‐toll‐like receptor (TLR)4‐interleukin (IL)‐23‐IL‐17A axis in drug‐induced damage‐associated lethal hepatitis: Interaction of γδ T cells with macrophages
Xuefu Wang, Rui Sun, Haiming Wei, Zhigang Tian – 23 July 2012 – Acetaminophen overdose causes acute liver inflammation with neutrophil infiltration; however, the mechanism of damage‐associated inflammation has not been elucidated. In this study we found that the HMGB1‐TLR4‐IL‐23‐IL‐17A axis played a crucial role in acetaminophen‐induced infiltration of neutrophils and liver injury. Notably, interleukin (IL)‐17A and IL‐23 significantly increased after acetaminophen challenge.
Genome‐wide association analysis in Primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4
David Ellinghaus, Trine Folseraas, Kristian Holm, Eva Ellinghaus, Espen Melum, Tobias Balschun, Jon K. Laerdahl, Alexey Shiryaev, Daniel N. Gotthardt, Tobias J. Weismüller, Christoph Schramm, Michael Wittig, Annika Bergquist, Einar Björnsson, Hanns‐Ulrich Marschall, Morten Vatn, Andreas Teufel, Christian Rust, Christian Gieger, H‐Erich Wichmann, Heiko Runz, Martina Sterneck, Christian Rupp, Felix Braun, Rinse K. Weersma, Cisca Wijmenga, Cyriel Y. Ponsioen, Christopher G. Mathew, Paul Rutgeerts, Séverine Vermeire, Erik Schrumpf, Johannes R. Hov, Michael P. Manns, Kirsten M.
Is liver transplantation a risk factor for cardiovascular disease? a meta‐analysis of observational studies
Surabhi Madhwal, Ashish Atreja, Mazen Albeldawdi, Rocio Lopez, Anthony Post, Marco A. Costa – 20 July 2012 – Up to two‐thirds of patients develop metabolic syndrome within the first 5 years after orthotopic liver transplantation (OLT). However, data on overall cardiovascular (CV) morbidity and mortality among OLT recipients and particularly those who develop metabolic syndrome remain elusive.