Is liver transplantation a risk factor for cardiovascular disease? a meta‐analysis of observational studies

Surabhi Madhwal, Ashish Atreja, Mazen Albeldawdi, Rocio Lopez, Anthony Post, Marco A. Costa – 20 July 2012 – Up to two‐thirds of patients develop metabolic syndrome within the first 5 years after orthotopic liver transplantation (OLT). However, data on overall cardiovascular (CV) morbidity and mortality among OLT recipients and particularly those who develop metabolic syndrome remain elusive.

CD40 inhibits replication of hepatitis C virus in primary human hepatocytes by c‐jun N terminal kinase activation independent from the interferon pathway

Sibylle J. Rau, Eberhard Hildt, Kiyoshi Himmelsbach, Robert Thimme, Takaji Wakita, Hubert E. Blum, Richard Fischer – 19 July 2012 – CD40, a member of the tumor necrosis factor receptor family, and its ligand, CD40L (CD154), are important regulators of the antiviral immune response. CD40L is up‐regulated on lymphocytes and CD40 on hepatocytes during infection with hepatitis C virus (HCV); we investigated the role of CD40 signaling during HCV replication in hepatocytes.

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