Ylva Bonde, Torsten Plösch, Folkert Kuipers, Bo Angelin, Mats Rudling – 24 July 2012 – Secretion of cholesterol into bile is important for the elimination of cholesterol from the body. Thyroid hormone (TH) increases biliary cholesterol secretion and hepatic gene expression of adenosine triphosphate (ATP)‐binding cassette, subfamily G (WHITE), member 5 (ABCG5) and ATP‐binding cassette, subfamily G (WHITE), member 8 (ABCG8), two half‐transporters that act as a heterodimeric complex promoting sterol secretion.

Tammy T. Hshieh, Vinay Sundaram, Robert M. Najarian, Douglas W. Hanto, Seth J. Karp, Michael P. Curry – 24 July 2012

Sandra Pommey, Bo Lu, Jennifer McRae, John Stagg, Prue Hill, Evelyn Salvaris, Simon C. Robson, Anthony J.F. d'Apice, Peter J. Cowan, Karen M. Dwyer – 24 July 2012 – Ischemia‐reperfusion injury (IRI) is a major limiting event for successful liver transplantation, and CD4+ T cells and invariant natural killer T (iNKT) cells have been implicated in promoting IRI. We hypothesized that hepatic overexpression of CD39, an ectonucleotidase with antiinflammatory functions, will protect liver grafts after prolonged cold ischemia.

Eric S. Orman, Michael W. Fried – 23 July 2012 – Watch the interview with the authors

Mark S. Sulkowski – 23 July 2012 – Watch the interview with the author

Nezam H. Afdhal – 23 July 2012 – Watch a video presentation of this article

Diana L. Sylvestre – 23 July 2012 – Watch an interview with the author

Qinggong Yuan, Komal Loya, Bhavna Rani, Selina Möbus, Asha Balakrishnan, Jutta Lamle, Toni Cathomen, Arndt Vogel, Michael P. Manns, Michael Ott, Tobias Cantz, Amar Deep Sharma – 23 July 2012 – The tightly controlled replication of hepatocytes in liver regeneration and uncontrolled proliferation of tumor cells in hepatocellular carcinoma (HCC) are often modulated by common regulatory pathways. Several microRNAs (miRNAs) are involved in HCC progression by modulating posttranscriptional expression of multiple target genes.

Jason Schwartz, Heather Thiesset, Terry Box, William Hutson, John Sorensen – 23 July 2012

Rania Rabie, Khalid Mumtaz, Eberhard L. Renner – 23 July 2012 – Cyclosporine A (CSA), but not tacrolimus (TAC), inhibits hepatitis C virus (HCV) replication in vitro. Clinical reports on the efficacy of interferon‐α (IFNα)–based antiviral therapy (AVT) for recurrent HCV after liver transplantation (LT) with CSA and TAC are conflicting. Our aim was to assess whether AVT for recurrent HCV after LT is more effective with CSA or TAC. We performed an electronic database search (1995‐2012) and a manual abstract search (2005‐2012).