Heather L. Van Sweringen, Nozomu Sakai, Ralph C. Quillin, Jeff Bailey, Rebecca Schuster, John Blanchard, Holly Goetzman, Charles C. Caldwell, Michael J. Edwards, Alex B. Lentsch – 7 September 2012 – Previous studies have demonstrated the significance of signaling through the CXC chemokine receptor‐2 (CXCR2) receptor in the process of recovery and regeneration of functional liver mass after hepatic ischemia/reperfusion (I/R). CXCR2 is constitutively expressed on both neutrophils and hepatocytes; however, the cell‐specific roles of this receptor are unknown.

Mercedes Vazquez‐Chantada, Aintzane Gonzalez‐Lahera, Ibon Martinez‐Arranz, Carmelo Garcia‐Monzon, Manuela M. Regueiro, Juan L. Garcia‐Rodriguez, Karin A. Schlangen, Iñaki Mendibil, Naiara Rodriguez‐Ezpeleta, Juan J. Lozano, Karina Banasik, Johanne M. Justesen, Torben Joergensen, Daniel R. Witte, Torsten Lauritzen, Torben Hansen, Oluf Pedersen, Nicolas Veyrie, Karine Clement, Joan Tordjman, Albert Tran, Yannik Le Marchand‐Brustel, Xabier Buque, Patricia Aspichueta, Jose J. Echevarria‐Uraga, Antonio Martin‐Duce, Joan Caballeria, Philippe Gual, Azucena Castro, Jose M. Mato, Maria L.

Shadi Abu‐Hayyeh, Georgia Papacleovoulou, Anita Lövgren‐Sandblom, Mehreen Tahir, Olayiwola Oduwole, Nurul Akmal Jamaludin, Sabiha Ravat, Vanya Nikolova, Jenny Chambers, Clare Selden, Myrddin Rees, Hanns‐Ulrich Marschall, Malcolm G. Parker, Catherine Williamson – 7 September 2012 – Intrahepatic cholestasis of pregnancy (ICP) is the most prevalent pregnancy‐specific liver disease and is associated with an increased risk of adverse fetal outcomes, including preterm labor and intrauterine death.

George A. Diaz, Lauren S. Krivitzky, Masoud Mokhtarani, William Rhead, James Bartley, Annette Feigenbaum, Nicola Longo, William Berquist, Susan A. Berry, Renata Gallagher, Uta Lichter‐Konecki, Dennis Bartholomew, Cary O. Harding, Stephen Cederbaum, Shawn E. McCandless, Wendy Smith, Gerald Vockley, Stephen A. Bart, Mark S. Korson, David Kronn, Roberto Zori, J. Lawrence Merritt, Sandesh C.S. Nagamani, Joseph Mauney, Cynthia LeMons, Klara Dickinson, Tristen L. Moors, Dion F. Coakley, Bruce F.

George A. Diaz, Lauren S. Krivitzky, Masoud Mokhtarani, William Rhead, James Bartley, Annette Feigenbaum, Nicola Longo, William Berquist, Susan A. Berry, Renata Gallagher, Uta Lichter‐Konecki, Dennis Bartholomew, Cary O. Harding, Stephen Cederbaum, Shawn E. McCandless, Wendy Smith, Gerald Vockley, Stephen A. Bart, Mark S. Korson, David Kronn, Roberto Zori, J. Lawrence Merritt, Sandesh C.S. Nagamani, Joseph Mauney, Cynthia LeMons, Klara Dickinson, Tristen L. Moors, Dion F. Coakley, Bruce F.

Valentina Medici, Noreene M. Shibata, Kusum K. Kharbanda, Janine M. LaSalle, Rima Woods, Sarah Liu, Jesse A. Engelberg, Sridevi Devaraj, Natalie J. Török, Joy X. Jiang, Peter J. Havel, Bo Lönnerdal, Kyoungmi Kim, Charles H. Halsted – 4 September 2012 – Hepatic methionine metabolism may play an essential role in regulating methylation status and liver injury in Wilson's disease (WD) through the inhibition of S‐adenosylhomocysteine hydrolase (SAHH) by copper (Cu) and the consequent accumulation of S‐adenosylhomocysteine (SAH).

Kari Nejak‐Bowen, Alexander Kikuchi, Satdarshan P.S. Monga – 3 September 2012 – Wnt/β‐catenin signaling plays an important role in hepatic homeostasis, especially in liver development, regeneration, and cancer, and loss of β‐catenin signaling is often associated with increased apoptosis. To elucidate how β‐catenin may be regulating hepatocyte survival, we investigated the susceptibility of β‐catenin conditional knockout (KO) mice and their wild‐type (WT) littermates to Fas and tumor necrosis factor‐α (TNF‐α), two common pathways of hepatocyte apoptosis.

Frank K. Huynh, Ursula H. Neumann, Ying Wang, Brian Rodrigues, Timothy J. Kieffer, Scott D. Covey – 3 September 2012 – Obesity is highly associated with dyslipidemia and cardiovascular disease. However, the mechanism behind this association is not completely understood. The hormone leptin may be a molecular link between obesity and dysregulation of lipid metabolism. Leptin can affect lipid metabolism independent of its well‐known effects on food intake and energy expenditure, but exactly how this occurs is ill‐defined.

Nedim Hadžić – 3 September 2012

Tai‐Chung Tseng, Chun‐Jen Liu, Hung‐Chih Yang, Tung‐Hung Su, Chia‐Chi Wang, Chi‐Ling Chen, Cheng‐An Hsu, Stephanie Fang‐Tzu Kuo, Chen‐Hua Liu, Pei‐Jer Chen, Ding‐Shinn Chen, Jia‐Horng Kao – 3 September 2012 – Chronic hepatitis B patients with high viral loads are at increased risk of cirrhosis and hepatocellular carcinoma (HCC). In patients with low viral loads, higher hepatitis B surface antigen (HBsAg) levels have been shown to predict HCC development.