Maria Beatriz Herrera, Valentina Fonsato, Stefania Bruno, Cristina Grange, Nicholas Gilbo, Renato Romagnoli, Ciro Tetta, Giovanni Camussi – 24 July 2012 – Liver transplantation is currently the only effective therapy for fulminant liver failure, but its use is limited by the scarcity of organs for transplantation, high costs, and lifelong immunosuppression. Here we investigated whether human liver stem cells (HLSCs) protect from death in a lethal model of fulminant liver failure induced by intraperitoneal injection of D‐galactosamine and lipopolysaccharide in SCID mice.

David Ellinghaus, Trine Folseraas, Kristian Holm, Eva Ellinghaus, Espen Melum, Tobias Balschun, Jon K. Laerdahl, Alexey Shiryaev, Daniel N. Gotthardt, Tobias J. Weismüller, Christoph Schramm, Michael Wittig, Annika Bergquist, Einar Björnsson, Hanns‐Ulrich Marschall, Morten Vatn, Andreas Teufel, Christian Rust, Christian Gieger, H‐Erich Wichmann, Heiko Runz, Martina Sterneck, Christian Rupp, Felix Braun, Rinse K. Weersma, Cisca Wijmenga, Cyriel Y. Ponsioen, Christopher G. Mathew, Paul Rutgeerts, Séverine Vermeire, Erik Schrumpf, Johannes R. Hov, Michael P. Manns, Kirsten M.

Xuefu Wang, Rui Sun, Haiming Wei, Zhigang Tian – 23 July 2012 – Acetaminophen overdose causes acute liver inflammation with neutrophil infiltration; however, the mechanism of damage‐associated inflammation has not been elucidated. In this study we found that the HMGB1‐TLR4‐IL‐23‐IL‐17A axis played a crucial role in acetaminophen‐induced infiltration of neutrophils and liver injury. Notably, interleukin (IL)‐17A and IL‐23 significantly increased after acetaminophen challenge.

Jiajie Hou, Juan Xu, Runqiu Jiang, Youjing Wang, Chen Chen, Lei Deng, Xingxu Huang, Xuehao Wang, Beicheng Sun – 23 July 2012 – Protein tyrosine phosphatase receptor type O (PTPRO), one of the receptor types of phosphotyrosine phosphatases (PTP), was recently described as a tumor suppressor in various kinds of cancers. We aimed to clarify the role of PTPRO in hepatocellular carcinoma (HCC).

Douglas Mogul, Kathleen B. Schwarz – 23 July 2012 – Watch an interview with Dr. Schwarz

Sanjeev Arora, Karla Thornton, Andrea Bradford – 23 July 2012 – Watch a video presentation of this article

Mark S. Sulkowski – 23 July 2012 – Watch the interview with the author

Kymberly D. Watt – 23 July 2012 – Key Points

Ho Jung An, Jeong Won Jang, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon, Myung Ah Lee, Young Kyoung You, Dong Goo Kim, Eun Sun Jung – 23 July 2012 – Liver transplantation (LT) is a curative modality for hepatocellular carcinoma (HCC), especially in patients with cirrhosis. However, there are still risks of recurrence. C‐reactive protein (CRP), an acute‐phase inflammatory reactant that is synthesized by hepatocytes, has been related to the prognosis of various malignancies, including HCC.

Nezam H. Afdhal – 23 July 2012 – Watch a video presentation of this article