Impact of primary biliary cirrhosis on perceived quality of life: The UK‐PBC national study

George F. Mells, Greta Pells, Julia L. Newton, Andrew J. Bathgate, Andrew K. Burroughs, Michael A. Heneghan, James M. Neuberger, Darren B. Day, Samantha J. Ducker, Richard N. Sandford, Graeme J. Alexander, David E.J. Jones, UK‐PBC Consortium – 7 March 2013 – Primary biliary cirrhosis (PBC) has a complex clinical phenotype, with debate about the extent and specificity of frequently described systemic symptoms such as fatigue.

The nutritional management of hepatic encephalopathy in patients with cirrhosis: International society for hepatic encephalopathy and nitrogen metabolism consensus

Piero Amodio, Chantal Bemeur, Roger Butterworth, Juan Cordoba, Akinobu Kato, Sara Montagnese, Misael Uribe, Hendrik Vilstrup, Marsha Y. Morgan – 7 March 2013 – Nitrogen metabolism plays a major role in the development of hepatic encephalopathy (HE) in patients with cirrhosis. Modulation of this relationship is key to the management of HE, but is not the only nutritional issue that needs to be addressed. The assessment of nutritional status in patients with cirrhosis is problematic.

Interferon regulatory factor 9 protects against hepatic insulin resistance and steatosis in male mice

Xin‐An Wang, Ran Zhang, Dingsheng Jiang, Wei Deng, Shumin Zhang, Shan Deng, Jinfeng Zhong, Tao Wang, Li‐Hua Zhu, Li Yang, Shufen Hong, Sen Guo, Ke Chen, Xiao‐Fei Zhang, Zhigang She, Yingjie Chen, Qinglin Yang, Xiao‐Dong Zhang, Hongliang Li – 7 March 2013 – Obesity is a calorie‐excessive state associated with high risk of diabetes, atherosclerosis, and certain types of tumors. Obesity may induce inflammation and insulin resistance (IR).

MicroRNA‐216a/217‐induced epithelial‐mesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancer

Hongping Xia, London Lucien P.J. Ooi, Kam M. Hui – 7 March 2013 – Tumor recurrence and metastases are the major obstacles to improving the prognosis of patients with hepatocellular carcinoma (HCC). To identify novel risk factors associated with HCC recurrence and metastases, we have established a panel of recurrence‐associated microRNAs (miRNAs) by comparing miRNA expression in recurrent and nonrecurrent human HCC tissue samples using microarrays (recurrence is defined as recurrent disease occurring within a 2‐year time point of the original treatment).

An unbalance between von Willebrand factor and ADAMTS13 in acute liver failure: Implications for hemostasis and clinical outcome

Greg C. G. Hugenholtz, Jelle Adelmeijer, Joost C. M. Meijers, Robert J. Porte, R. Todd Stravitz, Ton Lisman – 6 March 2013 – Emerging evidence supports the concept of a rebalanced hemostatic state in liver disease as a result of a commensurate decline in prohemostatic and antihemostatic drivers. In the present study, we assessed levels and functionality of the platelet‐adhesive protein von Willebrand factor (VWF) and its cleaving protease ADAMTS13 in the plasma of patients with acute liver injury and acute liver failure (ALI/ALF).

Preparing for the inevitable: The death of a living liver donor

Charles Miller, Martin L. Smith, Masato Fujiki, Teresa Diago Uso, Cristiano Quintini – 6 March 2013 – Living donor liver transplantation (LDLT) is associated with a low but finite and well‐documented risk of donor morbidity and mortality, so organizations and individuals involved in this activity must accept the fact that a donor death is a question of when and not if.

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