FGF3/FGF4 amplification and multiple lung metastases in responders to sorafenib in hepatocellular carcinoma

Tokuzo Arao, Kazuomi Ueshima, Kazuko Matsumoto, Tomoyuki Nagai, Hideharu Kimura, Satoru Hagiwara, Toshiharu Sakurai, Seiji Haji, Akishige Kanazawa, Hisashi Hidaka, Yukihiro Iso, Keiichi Kubota, Mitsuo Shimada, Tohru Utsunomiya, Masashi Hirooka, Yoichi Hiasa, Yoshikazu Toyoki, Kenichi Hakamada, Kohichiroh Yasui, Takashi Kumada, Hidenori Toyoda, Shuichi Sato, Hiroyuki Hisai, Teiji Kuzuya, Kaoru Tsuchiya, Namiki Izumi, Shigeki Arii, Kazuto Nishio, Masatoshi Kudo – 13 August 2012 – The response rate to sorafenib in hepatocellular carcinoma (HCC) is relatively low (0.7%‐3%), however, rapid and d

Hepatic encephalopathy is associated with decreased cerebral oxygen metabolism and blood flow, not increased ammonia uptake

Gitte Dam, Susanne Keiding, Ole L. Munk, Peter Ott, Hendrik Vilstrup, Lasse K. Bak, Helle S. Waagepetersen, Arne Schousboe, Michael Sørensen – 10 August 2012 – Studies have shown decreased cerebral oxygen metabolism (CMRO2) and blood flow (CBF) in patients with cirrhosis with hepatic encephalopathy (HE). It remains unclear, however, whether these disturbances are associated with HE or with cirrhosis itself and how they may relate to arterial blood ammonia concentration and cerebral metabolic rate of blood ammonia (CMRA).

Predictors of early graft survival after pediatric liver transplantation

Ruben Ciria, Diego Davila, Shirin E. Khorsandi, Faisal Dar, Roberto Valente, Javier Briceño, Hector Vilca‐Melendez, Anil Dhawan, Mohamed Rela, Nigel D. Heaton – 10 August 2012 – The objective of this study was to identify peritransplant predictors of early graft survival and posttransplant parameters that could be used to predict early graft outcomes after pediatric liver transplantation (PLT). The response of children to liver dysfunction after liver transplantation (LT) is poor.

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