Immunoproteomic Analysis of Potentially Severe Non‐Graft‐Versus‐Host Disease Hepatitis After Allogenic Bone Marrow Transplantation

Elvire Beleoken, Rodolphe Sobesky, Jean‐Pierre Le Caer, François Le Naour, Mylène Sebagh, Nicolas Moniaux, Bruno Roche, Mohammad Zahid Mustafa, Catherine Guettier, Catherine Johanet, Didier Samuel, Jean‐Henri Bouhris, Jean‐Charles Duclos‐Vallee, Eric Ballot – 22 August 2012 – The development of potentially severe non‐graft‐versus‐host disease (GVHD) hepatitis resembling autoimmune hepatitis (AIH) has been reported after bone marrow transplantation (BMT).

Keratin 19 demonstration of canal of hering loss in primary biliary cirrhosis: “Minimal Change PBC”?

Fahad M. Khan, Arathi Rajendra Komarla, Paulo G. Mendoza, Henry C. Bodenheimer, Neil D. Theise – 22 August 2012 – Liver biopsy is important for diagnosing primary biliary cirrhosis (PBC). Prior investigations suggest that immunostaining for biliary keratin 19 (K19) may show the earliest changes suspicious for PBC, namely, loss of the canals of Hering (CoH).

Interferon regulatory factor 3 deficiency leads to interleukin‐17‐mediated liver ischemia‐reperfusion injury

Patrizia Loi, Qing Yuan, David Torres, Sandrine Delbauve, Marie‐Aline Laute, Marie‐Claude Lalmand, Michel Pétein, Stanislas Goriely, Michel Goldman, Véronique Flamand – 22 August 2012 – Interferon regulatory factor 3 (IRF3) is an important transcription factor in Toll‐like receptor 4 (TLR4) signaling, a pathway that is known to play a critical role in liver ischemia‐reperfusion injury. In order to decipher the involvement of IRF3 in this setting, we first compared the intensity of hepatic lesions in IRF3‐deficient versus wildtype mice.

Adoptive transfer of ex vivo expanded regulatory T cells in an autoimmune hepatitis murine model restores peripheral tolerance

Pascal Lapierre, Kathie Béland, Roland Yang, Fernando Alvarez – 22 August 2012 – Autoimmune hepatitis (AIH) is characterized by a loss of immunological tolerance to hepatocytes. Patients respond well to immunosuppression but progression to endstage liver disease occurs in 10%‐20% of cases, leading to liver transplantation. Using a murine model of type 2 AIH, we identified susceptibility factors for autoimmune hepatitis and attempted to restore immunological tolerance to liver autoantigens.

Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics

Evaggelia Liaskou, Henning W. Zimmermann, Ka‐Kit Li, Ye H. Oo, Shankar Suresh, Zania Stamataki, Omar Qureshi, Patricia F. Lalor, Jean Shaw, Wing‐kin Syn, Stuart M. Curbishley, David H. Adams – 22 August 2012 – Liver fibrosis is a wound healing response to chronic liver injury and inflammation in which macrophages and infiltrating monocytes participate in both the development and resolution phase. In humans, three monocyte subsets have been identified: the classical CD14++CD16−, intermediate CD14++CD16+, and nonclassical CD14+CD16++ monocytes.

In Vivo hyperpolarized carbon‐13 magnetic resonance spectroscopy reveals increased pyruvate carboxylase flux in an insulin‐resistant mouse model

Philip Lee, Waifook Leong, Trish Tan, Miangkee Lim, Weiping Han, George K. Radda – 22 August 2012 – The pathogenesis of type 2 diabetes is characterized by impaired insulin action and increased hepatic glucose production (HGP). Despite the importance of hepatic metabolic aberrations in diabetes development, there is currently no molecular probe that allows measurement of hepatic gluconeogenic pathways in vivo and in a noninvasive manner.

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