Anna Moles, Ana M. Sanchez, Paul S. Banks, Lindsay B. Murphy, Saimir Luli, Lee Borthwick, Andrew Fisher, Steven O'Reilly, Jacob M. van Laar, Steven A. White, Neil D. Perkins, Alastair D. Burt, Derek A. Mann, Fiona Oakley – 19 September 2012 – Phosphorylation of the RelA subunit at serine 536 (RelA‐P‐Ser536) is important for hepatic myofibroblast survival and is mechanistically implicated in liver fibrosis.

Rachael A. Turner, Eliane Wauthier, Oswaldo Lozoya, Randall McClelland, James E. Bowsher, Claire Barbier, Glenn Prestwich, Edward Hsu, David A. Gerber, Lola M. Reid – 19 September 2012 – Cell therapies are potential alternatives to organ transplantation for liver failure or dysfunction but are compromised by inefficient engraftment, cell dispersal to ectopic sites, and emboli formation.

David van der Poorten, Caroline F. Samer, Mehdi Ramezani‐Moghadam, Sally Coulter, Marina Kacevska, Dennis Schrijnders, Lindsay E. Wu, Duncan McLeod, Elisabetta Bugianesi, Mina Komuta, Tania Roskams, Christopher Liddle, Lionel Hebbard, Jacob George – 19 September 2012 – Advanced liver fibrosis in nonalcoholic steatohepatitis (NASH) is often accompanied by a reduction in hepatic fat to the point of complete fat loss (burnt‐out NASH), but the mechanisms behind this phenomenon have not been elucidated. Adiponectin is raised in cirrhosis of any cause and has potent antisteatotic activity.

Jieliang Chen, Min Wu, Xiaonan Zhang, Wen Zhang, Zhanqing Zhang, Lixiang Chen, Jing He, Ye Zheng, Cuncun Chen, Fan Wang, Yunwen Hu, Xiaohui Zhou, Cong Wang, Yang Xu, Mengji Lu, Zhenghong Yuan – 19 September 2012 – Treatment with exogenous interferon (IFN)‐α is not effective in the majority of patients with chronic hepatitis B virus (HBV) infection. Recent evidence suggests that HBV has evolved strategies to block the nuclear translocation of signal transducer and activator of transcription (STAT) 1 to limit IFN‐α–induced cellular antiviral responses.

John Aston – 19 September 2012

Yasuji Arase, Mariko Kobayashi, Fumitaka Suzuki, Yoshiyuki Suzuki, Yusuke Kawamura, Norio Akuta, Masahiro Kobayashi, Hitomi Sezaki, Satoshi Saito, Tetsuya Hosaka, Kenji Ikeda, Hiromitsu Kumada, Tetsuro Kobayashi – 18 September 2012 – The aim of this retrospective cohort study was to assess the cumulative development incidence and predictive factors for malignancies after the termination of interferon (IFN) therapy in Japanese patients for hepatitis C virus (HCV). A total of 4,302 HCV‐positive patients treated with IFN were enrolled. The mean observation period was 8.1 years.

Kristin A. Anderson, Dongning Wang, Matthew D. Hirschey – 18 September 2012

Kristin Wahl, Martin Siegemund, Frank Lehner, Florian Vondran, Andreas Nüssler, Florian Länger, Till Krech, Roland Kontermann, Michael P. Manns, Klaus Schulze‐Osthoff, Klaus Pfizenmaier, Heike Bantel – 18 September 2012 – As the result of an increasing incidence and a prevalent therapy resistance of hepatocellular carcinoma (HCC), there is a strong need for novel strategies to enhance treatment responses in HCC.

Norihisa Ichinohe, Naoki Tanimizu, Hidekazu Ooe, Yukio Nakamura, Toru Mizuguchi, Junko Kon, Koichi Hirata, Toshihiro Mitaka – 18 September 2012 – Oval cells and small hepatocytes (SHs) are known to be hepatic stem and progenitor cells. Although oval cells are believed to differentiate into mature hepatocytes (MHs) through SHs, the details of their differentiation process are not well understood. Furthermore, it is not certain whether the induced cells possess fully mature functions as MHs.

Zhong‐Bin Deng, Xiaoying Zhuang, Songwen Ju, Xiaoyu Xiang, Jingyao Mu, Qilong Wang, Hong Jiang, Lifeng Zhang, Mitchell Kronenberg, Jun Yan, Donald Miller, Huang‐Ge Zhang – 18 September 2012 – The Wnt/β‐catenin pathway has been known to play a role in induction of immune tolerance, but its role in the induction and maintenance of natural killer T (NKT) cell anergy is unknown. We found that activation of the Wnt pathways in the liver microenvironment is important for induction of NKT cell anergy.