Differentiation capacity of hepatic stem/progenitor cells isolated from D‐galactosamine‐treated rat livers

Norihisa Ichinohe, Naoki Tanimizu, Hidekazu Ooe, Yukio Nakamura, Toru Mizuguchi, Junko Kon, Koichi Hirata, Toshihiro Mitaka – 18 September 2012 – Oval cells and small hepatocytes (SHs) are known to be hepatic stem and progenitor cells. Although oval cells are believed to differentiate into mature hepatocytes (MHs) through SHs, the details of their differentiation process are not well understood. Furthermore, it is not certain whether the induced cells possess fully mature functions as MHs.

Increased apoptosis induction in hepatocellular carcinoma by a novel tumor‐targeted TRAIL fusion protein combined with bortezomib

Kristin Wahl, Martin Siegemund, Frank Lehner, Florian Vondran, Andreas Nüssler, Florian Länger, Till Krech, Roland Kontermann, Michael P. Manns, Klaus Schulze‐Osthoff, Klaus Pfizenmaier, Heike Bantel – 18 September 2012 – As the result of an increasing incidence and a prevalent therapy resistance of hepatocellular carcinoma (HCC), there is a strong need for novel strategies to enhance treatment responses in HCC.

Effect of type 2 diabetes on risk for malignancies includes hepatocellular carcinoma in chronic hepatitis C

Yasuji Arase, Mariko Kobayashi, Fumitaka Suzuki, Yoshiyuki Suzuki, Yusuke Kawamura, Norio Akuta, Masahiro Kobayashi, Hitomi Sezaki, Satoshi Saito, Tetsuya Hosaka, Kenji Ikeda, Hiromitsu Kumada, Tetsuro Kobayashi – 18 September 2012 – The aim of this retrospective cohort study was to assess the cumulative development incidence and predictive factors for malignancies after the termination of interferon (IFN) therapy in Japanese patients for hepatitis C virus (HCV). A total of 4,302 HCV‐positive patients treated with IFN were enrolled. The mean observation period was 8.1 years.

Human leukocyte antigen (HLA)‐B*57:01‐restricted activation of drug‐specific T cells provides the immunological basis for flucloxacillin‐induced liver injury

Manal M. Monshi, Lee Faulkner, Andrew Gibson, Rosalind E. Jenkins, John Farrell, Caroline J. Earnshaw, Ana Alfirevic, Karin Cederbrant, Ann K. Daly, Neil French, Munir Pirmohamed, B. Kevin Park, Dean J. Naisbitt – 17 September 2012 – The role of the adaptive immune system in adverse drug reactions that target the liver has not been defined. For flucloxacillin, a delay in the reaction onset and identification of human leukocyte antigen (HLA)‐B*57:01 as a susceptibility factor are indicative of an immune pathogenesis.

Dating the origin and dispersal of hepatitis B virus infection in humans and primates

Dimitrios Paraskevis, Gkikas Magiorkinis, Emmanouil Magiorkinis, Simon Y.W. Ho, Robert Belshaw, Jean‐Pierre Allain, Angelos Hatzakis – 17 September 2012 – The origin of hepatitis B virus (HBV) infection in humans and other primates remains largely unresolved. Understanding the origin of HBV is crucial because it provides a framework for studying the burden, and subsequently the evolution, of HBV pathogenicity with respect to changes in human population size and life expectancy.

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