Donor polymorphisms of toll‐like receptor 4 associated with graft failure in liver transplant recipients

William S. Oetting, Weihua Guan, David P. Schladt, Robert E. Leduc, Pamala A. Jacobson, Arthur J. Matas, Srinath Chinnakotla, Bernd Schröppel, Barbara T. Murphy, Ajay K. Israni – 15 September 2012 – There have been many reports showing significant associations between recipient genetic variants and allograft outcomes, including acute rejection and graft failure, but less is known about the contribution of the donor genotype.

Declining liver utilization for transplantation in the United States and the impact of donation after cardiac death

Eric S. Orman, A. Sidney Barritt, Stephanie B. Wheeler, Paul H. Hayashi – 11 September 2012 – Worsening donor liver quality resulting in decreased organ utilization may be contributing to the recent decline in liver transplants nationally. We sought to examine trends in donor liver utilization and the relationship between donor characteristics and nonuse. We used the United Network for Organ Sharing database to review all deceased adult organ donors in the United States from whom at least 1 solid organ was transplanted into a recipient. Trends in donor characteristics were examined.

Factors that affect deceased donor liver transplantation rates in the United States in addition to the model for end‐stage liver disease score

Pratima Sharma, Douglas E. Schaubel, Emily E. Messersmith, Mary K. Guidinger, Robert M. Merion – 11 September 2012 – Under an ideal implementation of Model for End‐Stage Liver Disease (MELD)–based liver allocation, the only factors that would predict deceased donor liver transplantation (DDLT) rates would be the MELD score, blood type, and donation service area (DSA). We aimed to determine whether additional factors are associated with DDLT rates in actual practice.

TRAIL but not FasL and TNFα, regulates IL‐33 expression in murine hepatocytes during acute hepatitis

Muhammad Imran Arshad, Claire Piquet‐Pellorce, Annie L'Helgoualc'h, Michel Rauch, Solène Patrat‐Delon, Frédéric Ezan, Catherine Lucas‐Clerc, Sabrina Nabti, Agnès Lehuen, Francisco Javier Cubero, Jean‐Philippe Girard, Christian Trautwein, Michel Samson – 10 September 2012 – Interleukin (IL)‐33, a member of the IL‐1 cytokine family, positively correlates with acute hepatitis and chronic liver failure in mice and humans. IL‐33 is expressed in hepatocytes and is regulated by natural killer T (NKT) cells during concanavalin A (ConA)‐induced acute liver injury.

Ammonia control and neurocognitive outcome among urea cycle disorder patients treated with glycerol phenylbutyrate

George A. Diaz, Lauren S. Krivitzky, Masoud Mokhtarani, William Rhead, James Bartley, Annette Feigenbaum, Nicola Longo, William Berquist, Susan A. Berry, Renata Gallagher, Uta Lichter‐Konecki, Dennis Bartholomew, Cary O. Harding, Stephen Cederbaum, Shawn E. McCandless, Wendy Smith, Gerald Vockley, Stephen A. Bart, Mark S. Korson, David Kronn, Roberto Zori, J. Lawrence Merritt, Sandesh C.S. Nagamani, Joseph Mauney, Cynthia LeMons, Klara Dickinson, Tristen L. Moors, Dion F. Coakley, Bruce F.

Ammonia control and neurocognitive outcome among urea cycle disorder patients treated with glycerol phenylbutyrate

George A. Diaz, Lauren S. Krivitzky, Masoud Mokhtarani, William Rhead, James Bartley, Annette Feigenbaum, Nicola Longo, William Berquist, Susan A. Berry, Renata Gallagher, Uta Lichter‐Konecki, Dennis Bartholomew, Cary O. Harding, Stephen Cederbaum, Shawn E. McCandless, Wendy Smith, Gerald Vockley, Stephen A. Bart, Mark S. Korson, David Kronn, Roberto Zori, J. Lawrence Merritt, Sandesh C.S. Nagamani, Joseph Mauney, Cynthia LeMons, Klara Dickinson, Tristen L. Moors, Dion F. Coakley, Bruce F.

Intrahepatic cholestasis of pregnancy levels of sulfated progesterone metabolites inhibit farnesoid X receptor resulting in a cholestatic phenotype

Shadi Abu‐Hayyeh, Georgia Papacleovoulou, Anita Lövgren‐Sandblom, Mehreen Tahir, Olayiwola Oduwole, Nurul Akmal Jamaludin, Sabiha Ravat, Vanya Nikolova, Jenny Chambers, Clare Selden, Myrddin Rees, Hanns‐Ulrich Marschall, Malcolm G. Parker, Catherine Williamson – 7 September 2012 – Intrahepatic cholestasis of pregnancy (ICP) is the most prevalent pregnancy‐specific liver disease and is associated with an increased risk of adverse fetal outcomes, including preterm labor and intrauterine death.

Solute carrier family 2 member 1 is involved in the development of nonalcoholic fatty liver disease

Mercedes Vazquez‐Chantada, Aintzane Gonzalez‐Lahera, Ibon Martinez‐Arranz, Carmelo Garcia‐Monzon, Manuela M. Regueiro, Juan L. Garcia‐Rodriguez, Karin A. Schlangen, Iñaki Mendibil, Naiara Rodriguez‐Ezpeleta, Juan J. Lozano, Karina Banasik, Johanne M. Justesen, Torben Joergensen, Daniel R. Witte, Torsten Lauritzen, Torben Hansen, Oluf Pedersen, Nicolas Veyrie, Karine Clement, Joan Tordjman, Albert Tran, Yannik Le Marchand‐Brustel, Xabier Buque, Patricia Aspichueta, Jose J. Echevarria‐Uraga, Antonio Martin‐Duce, Joan Caballeria, Philippe Gual, Azucena Castro, Jose M. Mato, Maria L.

Roles of hepatocyte and myeloid CXC chemokine receptor‐2 in liver recovery and regeneration after ischemia/reperfusion in mice

Heather L. Van Sweringen, Nozomu Sakai, Ralph C. Quillin, Jeff Bailey, Rebecca Schuster, John Blanchard, Holly Goetzman, Charles C. Caldwell, Michael J. Edwards, Alex B. Lentsch – 7 September 2012 – Previous studies have demonstrated the significance of signaling through the CXC chemokine receptor‐2 (CXCR2) receptor in the process of recovery and regeneration of functional liver mass after hepatic ischemia/reperfusion (I/R). CXCR2 is constitutively expressed on both neutrophils and hepatocytes; however, the cell‐specific roles of this receptor are unknown.

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