David van der Poorten, Caroline F. Samer, Mehdi Ramezani‐Moghadam, Sally Coulter, Marina Kacevska, Dennis Schrijnders, Lindsay E. Wu, Duncan McLeod, Elisabetta Bugianesi, Mina Komuta, Tania Roskams, Christopher Liddle, Lionel Hebbard, Jacob George – 19 September 2012 – Advanced liver fibrosis in nonalcoholic steatohepatitis (NASH) is often accompanied by a reduction in hepatic fat to the point of complete fat loss (burnt‐out NASH), but the mechanisms behind this phenomenon have not been elucidated. Adiponectin is raised in cirrhosis of any cause and has potent antisteatotic activity.

Rachael A. Turner, Eliane Wauthier, Oswaldo Lozoya, Randall McClelland, James E. Bowsher, Claire Barbier, Glenn Prestwich, Edward Hsu, David A. Gerber, Lola M. Reid – 19 September 2012 – Cell therapies are potential alternatives to organ transplantation for liver failure or dysfunction but are compromised by inefficient engraftment, cell dispersal to ectopic sites, and emboli formation.

Anna Moles, Ana M. Sanchez, Paul S. Banks, Lindsay B. Murphy, Saimir Luli, Lee Borthwick, Andrew Fisher, Steven O'Reilly, Jacob M. van Laar, Steven A. White, Neil D. Perkins, Alastair D. Burt, Derek A. Mann, Fiona Oakley – 19 September 2012 – Phosphorylation of the RelA subunit at serine 536 (RelA‐P‐Ser536) is important for hepatic myofibroblast survival and is mechanistically implicated in liver fibrosis.

Amy Dhirapong, Guo‐Xiang Yang, Steven Nadler, Weici Zhang, Koichi Tsuneyama, Patrick Leung, Stuart Knechtle, Aftab A. Ansari, Ross L. Coppel, Fu‐Tong Liu, Xiao‐Song He, M. Eric Gershwin – 19 September 2012 – Collectively, the data in both humans and murine models of human primary biliary cirrhosis (PBC) suggest that activated T cells, particularly CD8 T cells, play a critical role in biliary cell destruction.

Hacer Sahin, Erawan Borkham‐Kamphorst, Nicole T. do O, Marie‐Luise Berres, Michaela Kaldenbach, Petra Schmitz, Ralf Weiskirchen, Christian Liedtke, Konrad L. Streetz, Kathrin Maedler, Christian Trautwein, Hermann E. Wasmuth – 19 September 2012 – Aberrant expression of the chemokine CXC chemokine ligand (CXCL)10 has been linked to the severity of hepatitis C virus (HCV)‐induced liver injury, but the underlying molecular mechanisms remain unclear.

Vivek N. Iyer, Karen L. Swanson, Rodrigo Cartin‐Ceba, Ross A. Dierkhising, Charles B. Rosen, Julie K. Heimbach, Russell H. Wiesner, Michael J. Krowka – 19 September 2012 – Hepatopulmonary syndrome (HPS) is a pulmonary vascular disorder occurring as a consequence of advanced liver disease, characterized by hypoxemia due to intrapulmonary vascular dilatations. HPS independently increases mortality, regardless of the cause or severity of liver disease. Liver transplantation (LT) improves survival in HPS.

Courtney Wilkins, Jessica Woodward, Daryl T.‐Y. Lau, Amy Barnes, Michael Joyce, Nicola McFarlane, Jane A. McKeating, D. Lorne Tyrrell, Michael Gale – 19 September 2012 – Type 1 interferon (IFN) continues to be the foundation for the current standard of care combination therapy for chronic hepatitis C virus (HCV) infection, yet the component interferon‐stimulated genes (ISGs) that mediate the antiviral actions of IFN are not fully defined.

Yan Yan, Yue‐Chen Luo, Hai‐Ying Wan, Jun Wang, Pei‐Pei Zhang, Min Liu, Xin Li, Shengping Li, Hua Tang – 19 September 2012 – MicroRNAs (miRNAs) have been reported to be associated with the development of cancers. However, the function of miRNAs in human hepatocellular carcinoma (HCC) remains largely undefined. Here we found that overexpression of miR‐10a promoted the migration and invasion of QGY‐7703 and HepG2 cells in vitro but suppressed metastasis in vivo.

Dorothy Ngo‐Yin Fan, Felice Ho‐Ching Tsang, Aegean Hoi‐Kam Tam, Sandy Leung‐Kuen Au, Carmen Chak‐Lui Wong, Lai Wei, Joyce Man‐Fong Lee, Xianghuo He, Irene Oi‐Lin Ng, Chun‐Ming Wong – 18 September 2012 – Hepatocellular carcinoma (HCC) is a major liver malignancy. We previously demonstrated that deregulation of epigenetic regulators is a common event in human HCC.

Zhong‐Bin Deng, Xiaoying Zhuang, Songwen Ju, Xiaoyu Xiang, Jingyao Mu, Qilong Wang, Hong Jiang, Lifeng Zhang, Mitchell Kronenberg, Jun Yan, Donald Miller, Huang‐Ge Zhang – 18 September 2012 – The Wnt/β‐catenin pathway has been known to play a role in induction of immune tolerance, but its role in the induction and maintenance of natural killer T (NKT) cell anergy is unknown. We found that activation of the Wnt pathways in the liver microenvironment is important for induction of NKT cell anergy.