JD induced pluripotent stem cell–derived hepatocytes faithfully recapitulate the pathophysiology of familial hypercholesterolemia
Max A. Cayo, Jun Cai, Ann DeLaForest, Fallon K. Noto, Masato Nagaoka, Brian S. Clark, Ross F. Collery, Karim Si‐Tayeb, Stephen A. Duncan – 31 May 2012 – Elevated levels of low‐density lipoprotein cholesterol (LDL‐C) in plasma are a major contributor to cardiovascular disease, which is the leading cause of death worldwide. Genome‐wide association studies (GWAS) have identified 95 loci that associate with control of lipid/cholesterol metabolism.