Philip Roelandt, Aline Antoniou, Louis Libbrecht, Werner Van Steenbergen, Wim Laleman, Chris Verslype, Schalk Van der Merwe, Frederik Nevens, Rita De Vos, Evelyne Fischer, Marco Pontoglio, Frédéric Lemaigre, David Cassiman – 18 June 2012 – Heterozygous deletion or mutation in hepatocyte nuclear factor 1 homeobox B/transcription factor 2 (HNF1B/TCF2) causes renal cyst and diabetes syndrome (OMIM #137920). Mice with homozygous liver‐specific deletion of Hnf1β revealed that a complete lack of this factor leads to ductopenia and bile duct dysplasia, in addition to mild hepatocyte defects.

Pedro Elias Marques, Sylvia Stella Amaral, Gustavo Batista Menezes – 18 June 2012

Naoki Oishi, Mia R. Kumar, Stephanie Roessler, Junfang Ji, Marshonna Forgues, Anuradha Budhu, Xuelian Zhao, Jesper B. Andersen, Qing‐Hai Ye, Hu‐Liang Jia, Lun‐Xiu Qin, Taro Yamashita, Hyun Goo Woo, Yoon Jun Kim, Shuichi Kaneko, Zhao‐You Tang, Snorri S. Thorgeirsson, Xin Wei Wang – 18 June 2012 – Intrahepatic cholangiocellular carcinoma (ICC) is the second most common type of primary liver cancer. However, its tumor heterogeneity and molecular characteristics are largely unknown.

Lili Wang – 18 June 2012

Victoria M. Velazquez, Huiming Hon, Chris Ibegbu, Stuart J. Knechtle, Allan D. Kirk, Arash Grakoui – 18 June 2012 – Chronic hepatitis C virus (HCV) infection is a serious disease that can result in numerous long‐term complications leading to liver failure or death. Approximately 80% of people fail to clear their infection, largely as the result of weak, narrowly targeting or waning antiviral T‐cell responses.

Hitoshi Ikeda, Kenichiro Enooku, Ryunosuke Ohkawa, Kazuhiko Koike, Yutaka Yatomi – 18 June 2012

Robert J. Fontana, Eric A. Hughes, Henry Appelman, Robert Hindes, Dessislava Dimitrova, Marc Bifano – 18 June 2012 – A recurrent hepatitis C virus (HCV) infection after liver transplantation (LT) can lead to accelerated allograft injury and fibrosis. The aim of this article is to report the first ever use of daclatasvir (DCV; also known as BMS‐790052), a potent orally administered nonstructural 5A replication complex inhibitor, in combination with peginterferon α (PEG‐IFNα) and ribavirin in an LT recipient.

Vered Gazit, Jiansheng Huang, Alexander Weymann, David A. Rudnick – 18 June 2012 – Mice subjected to partial hepatectomy (PH) develop hypoglycemia, followed by increased systemic lipolysis and hepatic fat accumulation, prior to onset of hepatocellular proliferation. Strategies that disrupt these metabolic events inhibit regeneration. These observations suggest that alterations in metabolism in response to hepatic insufficiency promote liver regeneration. Hepatic expression of the peroxisome proliferator‐activated receptor gamma (PPARγ) influences fat accumulation in the liver.

Pietro Lampertico, Enrico Galmozzi, Massimo Colombo – 18 June 2012

Heiyoung Park, Elisavet Serti, Onyinyechi Eke, Brian Muchmore, Ludmila Prokunina‐Olsson, Stefania Capone, Antonella Folgori, Barbara Rehermann – 18 June 2012 – Early, vigorous intrahepatic induction of interferon (IFN)‐stimulated gene (ISG) induction is a feature of hepatitis C virus (HCV) infection, even though HCV inhibits the induction of type I IFNs in vitro.