Vitamin D binding protein gene polymorphisms and baseline vitamin D levels as predictors of antiviral response in chronic hepatitis C

Edmondo Falleti, Davide Bitetto, Carlo Fabris, Giovanna Fattovich, Annarosa Cussigh, Sara Cmet, Elisa Ceriani, Ezio Fornasiere, Michela Pasino, Donatella Ieluzzi, Mario Pirisi, Pierluigi Toniutto – 18 May 2012 – Vitamin D deficiency seems to predict the unsuccessful achievement of sustained viral response (SVR) after antiviral treatment in hepatitis C virus (HCV) difficult‐to‐treat genotypes. Vitamin D binding protein (GC) gene polymorphisms are known to influence vitamin D levels.

Liver sinusoidal endothelial cells contribute to CD8 T cell tolerance toward circulating carcinoembryonic antigen in mice

Bastian Höchst, Frank A. Schildberg, Jan Böttcher, Christina Metzger, Sebastian Huss, Andreas Türler, Markus Overhaus, Andreas Knoblich, Berthold Schneider, Dimitrios Pantelis, Christian Kurts, Jörg C. Kalff, Percy Knolle, Linda Diehl – 18 May 2012 – Immunity against cancer is impeded by local mechanisms promoting development of tumor‐specific T cell tolerance, such as regulatory T cells, myeloid‐derived suppressor cells, or immunosuppressive factors in the tumor microenvironment.

Resection of hepatocellular cancer ≤2 cm: Results from two Western centers

Sasan Roayaie, Khaled Obeidat, Carlo Sposito, Luigi Mariani, Sherrie Bhoori, Alessandro Pellegrinelli, Daniel Labow, Josep M. Llovet, Myron Schwartz, Vincenzo Mazzaferro – 11 May 2012 – Asian series have shown a 5‐year survival rate of ≈70% after resection of hepatocellular carcinoma (HCC) ≤2 cm. Western outcomes with resection have not been as good. In addition, ablation of HCC ≤2 cm has been shown to achieve competitive results, leaving the role of resection in these patients unclear.

Pharmacokinetic interaction between the hepatitis C virus protease inhibitor boceprevir and cyclosporine and tacrolimus in healthy volunteers

Ellen Hulskotte, Samir Gupta, Fengjuan Xuan, Marga van Zutven, Edward O'Mara, Hwa‐Ping Feng, John Wagner, Joan Butterton – 11 May 2012 – The hepatitis C virus protease inhibitor boceprevir is a strong inhibitor of cytochrome P450 3A4 and 3A5 (CYP3A4/5). Cyclosporine and tacrolimus are calcineurin inhibitor immunosuppressants used to prevent organ rejection after liver transplantation; both are substrates of CYP3A4. This two‐part pharmacokinetic interaction study evaluated boceprevir with cyclosporine (part 1) and tacrolimus (part 2).

Variant 1 of KIAA0101, overexpressed in hepatocellular carcinoma, prevents doxorubicin‐induced apoptosis by inhibiting p53 activation

Lijuan Liu, Xiaobei Chen, Shuixiang Xie, Chuanjie Zhang, Zhenpeng Qiu, Fan Zhu – 11 May 2012 – KIAA0101 overexpression was detected in numerous malignant solid tumors and involved in tumor progression; however, the correlation between KIAA0101 expression level and human hepatocellular carcinoma (HCC) was controversial.

Outcomes after living donor liver transplantation for acute liver failure in Japan: Results of a nationwide survey

Noriyo Yamashiki, Yasuhiko Sugawara, Sumihito Tamura, Nobuaki Nakayama, Makoto Oketani, Koji Umeshita, Shinji Uemoto, Satoshi Mochida, Hirohito Tsubouchi, Norihiro Kokudo – 11 May 2012 – Nationwide surveys of acute liver failure (ALF) are conducted annually in Japan, and 20% of patients with ALF undergo liver transplantation (LT). We extracted data for 212 patients who underwent LT for ALF from the nationwide survey database of the Intractable Liver Diseases Study Group of Japan.

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