Henri Duboc, Hélène Aelion, Dominique Rainteau, Sylvie Rajca, Harry Sokol, Lydie Humbert, Dominique Farabos, Benoit Coffin, Simon Weber, Raphaël Porcher, Olivier Varenne, Denis Duboc – 17 May 2012
Kiran Bambha, Nathan M. Bass – 17 May 2012
Pau Sancho‐Bru, José Altamirano, Ramon Bataller – 17 May 2012
Noriyo Yamashiki, Yasuhiko Sugawara, Sumihito Tamura, Nobuaki Nakayama, Makoto Oketani, Koji Umeshita, Shinji Uemoto, Satoshi Mochida, Hirohito Tsubouchi, Norihiro Kokudo – 11 May 2012 – Nationwide surveys of acute liver failure (ALF) are conducted annually in Japan, and 20% of patients with ALF undergo liver transplantation (LT). We extracted data for 212 patients who underwent LT for ALF from the nationwide survey database of the Intractable Liver Diseases Study Group of Japan.
Lijuan Liu, Xiaobei Chen, Shuixiang Xie, Chuanjie Zhang, Zhenpeng Qiu, Fan Zhu – 11 May 2012 – KIAA0101 overexpression was detected in numerous malignant solid tumors and involved in tumor progression; however, the correlation between KIAA0101 expression level and human hepatocellular carcinoma (HCC) was controversial.
Ellen Hulskotte, Samir Gupta, Fengjuan Xuan, Marga van Zutven, Edward O'Mara, Hwa‐Ping Feng, John Wagner, Joan Butterton – 11 May 2012 – The hepatitis C virus protease inhibitor boceprevir is a strong inhibitor of cytochrome P450 3A4 and 3A5 (CYP3A4/5). Cyclosporine and tacrolimus are calcineurin inhibitor immunosuppressants used to prevent organ rejection after liver transplantation; both are substrates of CYP3A4. This two‐part pharmacokinetic interaction study evaluated boceprevir with cyclosporine (part 1) and tacrolimus (part 2).
Sasan Roayaie, Khaled Obeidat, Carlo Sposito, Luigi Mariani, Sherrie Bhoori, Alessandro Pellegrinelli, Daniel Labow, Josep M. Llovet, Myron Schwartz, Vincenzo Mazzaferro – 11 May 2012 – Asian series have shown a 5‐year survival rate of ≈70% after resection of hepatocellular carcinoma (HCC) ≤2 cm. Western outcomes with resection have not been as good. In addition, ablation of HCC ≤2 cm has been shown to achieve competitive results, leaving the role of resection in these patients unclear.
Johann‐Martin Hempel, Gertrud Greif‐Higer, Thomas Kaufmann, Manfred E. Beutel – 10 May 2012 – Alcoholic liver cirrhosis (ALC) is a commonly accepted indication for liver transplantation (LT). Any alcohol consumption is considered a contraindication for LT. However, the assessment of abstinence in everyday practice mostly relies on patient self‐reporting, which must be considered highly unreliable. After consumption, ethanol is eliminated by alcohol dehydrogenase, with methanol accumulating in the blood.
Ashwin Woodhoo, Marta Iruarrizaga‐Lejarreta, Naiara Beraza, Juan L García‐Rodríguez, Nieves Embade, David Fernández‐Ramos, Nuria Martínez‐López, Virginia Gutiérrez‐De Juan, Beatriz Arteta, Juan Caballeria, Shelly C Lu, José M Mato, Marta Varela‐Rey, María L Martínez‐Chantar – 10 May 2012 – RNA‐binding proteins (RBPs) play a major role in the control of messenger RNA (mRNA) turnover and translation rates. We examined the role of the RBP, human antigen R (HuR), during cholestatic liver injury and hepatic stellate cell (HSC) activation.