Enhanced hepatocarcinogenesis in mouse models and human hepatocellular carcinoma by coordinate KLF6 depletion and increased messenger RNA splicing

Diana Vetter, Michal Cohen‐Naftaly, Augusto Villanueva, Youngmin A. Lee, Peri Kocabayoglu, Rebekka Hannivoort, Goutham Narla, Josep M. Llovet, Swan N. Thung, Scott L. Friedman – 26 April 2012 – KLF6‐SV1 (SV1), the major splice variant of KLF6, antagonizes the KLF6 tumor suppressor by an unknown mechanism. Decreased KLF6 expression in human hepatocellular carcinoma (HCC) correlates with increased mortality, but the contribution of increased SV1 is unknown.

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