Myristoylated PreS1‐domain of the hepatitis B virus L‐protein mediates specific binding to differentiated hepatocytes

Anja Meier, Stefan Mehrle, Thomas S. Weiss, Walter Mier, Stephan Urban – 5 December 2012 – Chronic infection with the human hepatitis B virus (HBV) is a global health problem and a main cause of progressive liver diseases. HBV exhibits a narrow host range, replicating primarily in hepatocytes. Both host and hepatocyte specificity presumably involve specific receptor interactions on the target cell; however, direct evidence for this hypothesis is missing.

Hypoxia inducible factor 2 alpha inhibits hepatocellular carcinoma growth through the transcription factor dimerization partner 3/ E2F transcription factor 1–dependent apoptotic pathway

Hai‐Xiang Sun, Yang Xu, Xin‐Rong Yang, Wei‐Min Wang, Haibo Bai, Ruo‐Yu Shi, Suresh K. Nayar, Ranjan P. Devbhandari, Yi‐zhou He, Qingfeng Zhu, Yun‐Fan Sun, Bo Hu, Mehtab Khan, Robert A. Anders, Jia Fan – 5 December 2012 – Hypoxia inducible factors (HIFs) are activated in many tumors and show either promoter or suppressor activity, depending on tumor cell biology and background. However, the role of HIF member HIF‐2α remains unclear in hepatocellular carcinoma (HCC).

Bile salt export pump is dysregulated with altered farnesoid X receptor isoform expression in patients with hepatocellular carcinoma

Yuan Chen, Xiulong Song, Leila Valanejad, Alexander Vasilenko, Vijay More, Xi Qiu, Weikang Chen, Yurong Lai, Angela Slitt, Matthew Stoner, Bingfang Yan, Ruitang Deng – 5 December 2012 – As a canalicular bile acid effluxer, the bile salt export pump (BSEP) plays a vital role in maintaining bile acid homeostasis. BSEP deficiency leads to severe cholestasis and hepatocellular carcinoma (HCC) in young children. Regardless of the etiology, chronic inflammation is the common pathological process for HCC development.

Hepatocyte nuclear factor 1β is a novel prognostic marker independent of the milan criteria in transplantable hepatocellular carcinoma: A retrospective analysis based on tissue microarrays

Ju Hyun Shim, Han Chu Lee, Seungbong Han, Hyo Jeong Kang, Eunsil Yu, Sung‐Gyu Lee – 2 December 2012 – We retrospectively investigated the prognostic value of hepatocyte nuclear factor 1 (HNF1) proteins in 159 liver transplant patients with hepatocellular carcinoma (HCC), including 36 (22.6%) exceeding the Milan criteria. The expression of alpha‐fetoprotein (AFP), HNF1α, and HNF1β was examined with immunohistochemistry on duplicate tissue microarray slides containing HCC tumor explants.

Early and Long‐Term Results of Routine Microsurgical Biliary Reconstruction in Living Donor Liver Transplantation

Tsan‐Shiun Lin, Chao‐Long Chen, Allan M. Concejero, Anthony Q. Yap, Yu‐Hung Lin, Chun‐Yi Liu, Yuan‐Cheng Chiang, Chih‐Chi Wang, Shih‐Ho Wang, Chih‐Che Lin, Chee‐Chien Yong, Yu‐Fan Cheng – 29 November 2012 – We describe our early and long‐term experience with routine biliary reconstruction via a microsurgical technique in living donor liver transplantation (LDLT). One hundred seventy‐seven grafts (including 3 dual grafts) were primarily transplanted into 174 recipients. The minimum follow‐up was 44 months.

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