Olaf Neumann, Miriam Kesselmeier, Robert Geffers, Rossella Pellegrino, Bernhard Radlwimmer, Katrin Hoffmann, Volker Ehemann, Peter Schemmer, Peter Schirmacher, Justo Lorenzo Bermejo, Thomas Longerich – 11 June 2012 – To identify new tumor‐suppressor gene candidates relevant for human hepatocarcinogenesis, we performed genome‐wide methylation profiling and vertical integration with array‐based comparative genomic hybridization (aCGH), as well as expression data from a cohort of well‐characterized human hepatocellular carcinomas (HCCs).

Shunji Nagai, Lloyd Brown, Atsushi Yoshida, Dean Kim, Marwan Kazimi, Marwan S. Abouljoud – 9 June 2012 – Minimally invasive procedures are considered to be safe and effective approaches to the management of surgical liver disease. However, this indication remains controversial for living donor hepatectomy. Between 2000 and 2011, living donor right hepatectomy (LDRH) was performed 58 times. Standard right hepatectomy was performed in 30 patients via a subcostal incision with a midline extension. Minimally invasive procedures began to be used for LDRH in 2008.

Masahiro Takahashi, Seigo Nishida, Zubin J. Panthaki, Ji Fan, Antonio Romano, Akin Tekin, Eddie R. Island, Jang I. Moon, David M. Levi, Andreas G. Tzakis – 9 June 2012

Wenhua Liang, Linwei Wu, Xiaoting Ling, Paul M. Schroder, Weiqiang Ju, Dongping Wang, Yushu Shang, Yuan Kong, Zhiyong Guo, Xiaoshun He – 9 June 2012 – Because of the severe organ shortage, living donor liver transplantation (LDLT) offers a timely alternative to deceased donor liver transplantation (DDLT) for patients with hepatocellular carcinoma (HCC). However, the higher recurrence rate of HCC after LDLT and the indication criteria remain controversial.

Changhua Ji, Konduru S.R. Sastry, Georg Tiefenthaler, Jennifer Cano, Tenny Tang, Zi Zong Ho, Denise Teoh, Sandhya Bohini, Antony Chen, Surya Sankuratri, Paul A. Macary, Patrick Kennedy, Han Ma, Stefan Ries, Klaus Klumpp, Erhard Kopetzki, Antonio Bertoletti – 9 June 2012 – During antiviral therapy, specific delivery of interferon‐α (IFNα) to infected cells may increase its antiviral efficacy, trigger a localized immune reaction, and reduce the side effects caused by systemic administration.

Shashi Bala, Jan Petrasek, Shiv Mundkur, Donna Catalano, Ivan Levin, Jeanine Ward, Hawau Alao, Karen Kodys, Gyongyi Szabo – 9 June 2012 – MicroRNAs are fine tuners of diverse biological responses and are expressed in various cell types of the liver. Here we hypothesized that circulating microRNAs (miRNAs) may serve as biomarkers of liver damage and inflammation.

Maria Elias‐Miró, Marta Massip‐Salcedo, Jens Raila, Florian Schweigert, Mariana Mendes‐Braz, Fernando Ramalho, Mónica B. Jiménez‐Castro, Araní Casillas‐Ramírez, Raquel Bermudo, Antoni Rimola, Juan Rodes, Carmen Peralta – 9 June 2012 – Steatotic livers show increased hepatic damage and impaired regeneration after partial hepatectomy (PH) under ischemia/reperfusion (I/R), which is commonly applied in clinical practice to reduce bleeding. The known function of retinol‐binding protein 4 (RBP4) is to transport retinol in the circulation.

Emmanuel Melloul, Dimitri Aristotle Raptis, Christian Eugen Oberkofler, Philipp Dutkowski, Mickael Lesurtel, Pierre‐Alain Clavien – 9 June 2012

Xiong Cai, Jian Zhai, David E. Kaplan, Yijun Zhang, Lining Zhou, Xutao Chen, Guangyang Qian, Qiudong Zhao, Yonghai Li, Lu Gao, Wenming Cong, Minghua Zhu, Zhenlin Yan, Lehua Shi, Dong Wu, Lixin Wei, Feng Shen, Mengchao Wu – 9 June 2012 – Hepatic progenitor cells (HPC) play important roles in both liver regeneration and carcinogenesis. Combined hepatocellular‐cholangiocarcinoma (CHC), a malignant primary liver tumor with poor prognosis, is thought to be of HPC origin. However, the prognostic significance of this etiology is not well defined.

Karolina Bojkowska, Fabio Aloisio, Marco Cassano, Adamandia Kapopoulou, Francesca Santoni de Sio, Nadine Zangger, Sandra Offner, Cristina Cartoni, Charles Thomas, Simon Quenneville, Kai Johnsson, Didier Trono – 8 June 2012 – The liver is characterized by sexually dimorphic gene expression translating into sex‐specific differences in lipid, drug, steroid hormone, and xenobiotic metabolism, with distinct responses of males and females to environmental challenges.