Sanjoy Roychowdhury, Megan R. McMullen, Sorana G. Pisano, Xiuli Liu, Laura E. Nagy – 14 December 2012 – Hepatocyte cell death via apoptosis and necrosis are major hallmarks of ethanol‐induced liver injury. However, inhibition of apoptosis is not sufficient to prevent ethanol‐induced hepatocyte injury or inflammation. Because receptor‐interacting protein kinase (RIP) 3–mediated necroptosis, a nonapoptotic cell death pathway, is implicated in a variety of pathological conditions, we tested the hypothesis that ethanol‐induced liver injury is RIP3‐dependent and RIP1‐independent.

Flavia H. Feier, Joao Seda Neto, Gilda Porta, Eduardo A. Fonseca, Rodrigo Vincenzi, Helry L. Cândido, Marcel Benavides, Bernardo Ketzer, Renata Pugliese, Irene K. Miura, Vera Baggio, Teresa Guimarães, Adriana Porta, Gustavo Foronda, Enis Donizete, Jose P. da Silva, Lucilia Faria, Mario Kondo, Paulo Chapchap – 13 December 2012 – The association of biliary atresia (BA) with congenital heart diseases has been extensively described, and there are a number of reports on the outcomes of patients in this group who undergo liver transplantation (LT).

Gregory T. Everson, John C. Hoefs, Claus U. Niemann, Kim M. Olthoff, Robert Dupuis, Shannon Lauriski, Andrea Herman, Norah Milne, Brenda W. Gillespie, Nathan P. Goodrich, James E. Everhart – 13 December 2012 – We quantified the rates of hepatic regeneration and functional recovery for 6 months after right hepatic lobectomy in living donors for liver transplantation.

Josh Levitsky, Gabriel C. Oniscu – 12 December 2012 – From May 16–19, 2012, the International Liver Transplantation Society held its annual congress in San Francisco, CA. More than 1300 registrants attended the meeting, which included a premeeting conference entitled Balancing Risk in Liver Transplantation, focused topic sessions, and a variety of oral and poster presentations. This report is not all‐inclusive and focuses on specific research abstracts on key topics in liver transplantation.

Safa Al‐Shamma, Balint Eross, Simon Mclaughlin – 12 December 2012

Brian R. Edlin – 12 December 2012 – Hepatitis C is the most prevalent bloodborne viral disease in the United States and the deadliest. This year, the U.S. Preventive Services Task Force (USPSTF) will update its 2004 hepatitis C guideline, which recommends against screening asymptomatic adults for hepatitis C. This guideline has hampered public health efforts to encourage screening and identify and refer infected persons for care by declaring that such interventions were not supported by the evidence.

Safa Al‐Shamma, Balint Eross, Simon Mclaughlin – 12 December 2012

Cleide G. da Silva, Peter Studer, Marco Skroch, Jerome Mahiou, Darlan C. Minussi, Clayton R. Peterson, Suzhuei W. Wilson, Virendra I. Patel, Averil Ma, Eva Csizmadia, Christiane Ferran – 12 December 2012 – Liver regeneration is of major clinical importance in the setting of liver injury, resection, and transplantation. A20, a potent antiinflammatory and nuclear factor kappa B (NF‐κB) inhibitory protein, has established pro‐proliferative properties in hepatocytes, in part through decreasing expression of the cyclin dependent kinase inhibitor, p21.

Jin‐feng Huang, Ying‐jun Guo, Chen‐xi Zhao, Sheng‐xian Yuan, Yue Wang, Guan‐nan Tang, Wei‐ping Zhou, Shu‐han Sun – 12 December 2012 – The hepatitis B virus X protein (HBx) has been implicated as an oncogene in both epigenetic modifications and genetic regulation during hepatocarcinogenesis, but the underlying mechanisms are not entirely clear. Long noncoding RNAs (lncRNAs), which regulate gene expression with little or no protein‐coding capacity, are involved in diverse biological processes and in carcinogenesis.

Brian R. Edlin – 12 December 2012 – Hepatitis C is the most prevalent bloodborne viral disease in the United States and the deadliest. This year, the U.S. Preventive Services Task Force (USPSTF) will update its 2004 hepatitis C guideline, which recommends against screening asymptomatic adults for hepatitis C. This guideline has hampered public health efforts to encourage screening and identify and refer infected persons for care by declaring that such interventions were not supported by the evidence.