Hedgehog/hyaluronic acid interaction network in nonalcoholic fatty liver disease, fibrosis, and hepatocellular carcinoma
Simonetta Pazzaglia, Loredana Cifaldi, Anna Saran, Valerio Nobili, Doriana Fruci, Anna Alisi – 13 April 2012
Oncogene‐specific formation of chemoresistant murine hepatic cancer stem cells
Edward Kai‐Hua Chow, Ling‐ling Fan, Xin Chen, J. Michael Bishop – 13 April 2012 – At least some cancer stem cells (CSCs) display intrinsic drug resistance that may thwart eradication of a malignancy by chemotherapy. We explored the genesis of such resistance by studying mouse models of liver cancer driven by either MYC or the combination of oncogenic forms of activation of v‐akt murine thymoma viral oncogene homolog (AKT) and NRAS. A common manifestation of chemoresistance in CSCs is efflux of the DNA‐binding dye Hoechst 33342.
Comparison of hepatitis C virus treatment between incarcerated and community patients
John P. Rice, David Burnett, Helena Tsotsis, Mary J. Lindstrom, Daniel D. Cornett, Patricia Voermans, Jill Sawyer, Rob Striker, Michael R. Lucey – 13 April 2012 – The prevalence of chronic hepatitis C virus (HCV) infection among incarcerated individuals in the United States is estimated to be between 12% and 31%. HCV treatment during incarceration is an attractive option because of improved access to health care and directly observed therapy.
The mechanism behind the novel fibrosis recently described in NASH in HEPATOLOGY 2011 and Elsewhere
Theresa C. Hemsworth‐Peterson – 13 April 2012
Association between diabetes, family history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis
Rohit Loomba, Maria Abraham, Aynur Unalp, Laura Wilson, Joel Lavine, Ed Doo, Nathan M. Bass, the Nonalcoholic Steatohepatitis Clinical Research Network – 13 April 2012 – Previous studies have shown familial aggregation of insulin resistance and nonalcoholic fatty liver disease (NAFLD). Therefore, we aimed to examine whether family history of diabetes mellitus (DM) is associated with nonalcoholic steatohepatitis (NASH) and fibrosis in patients with NAFLD.
Tim‐3/galectin‐9 signaling pathway mediates T‐cell dysfunction and predicts poor prognosis in patients with hepatitis B virus‐associated hepatocellular carcinoma
Hang Li, Ke Wu, Kaixiong Tao, Libo Chen, Qichang Zheng, Xiaoming Lu, Jun Liu, Liang Shi, Chuanqiao Liu, Guobin Wang, Weiping Zou – 13 April 2012 – The interaction between T cell immunoglobulin‐ and mucin‐domain‐containing molecule (Tim‐3) expressed on T helper 1 (Th1) cells, and its ligand, galectin‐9, negatively regulates Th1‐mediated immune responses. However, it is poorly understood if and how the Tim‐3/galectin‐9 signaling pathway is involved in immune escape in patients with hepatocellular carcinoma (HCC).
Antagonism of sphingosine 1‐phosphate receptor 2 causes a selective reduction of portal vein pressure in bile duct‐ligated rodents
Yuko Kageyama, Hitoshi Ikeda, Naoko Watanabe, Masakazu Nagamine, Yoshika Kusumoto, Mitsuru Yashiro, Yumiko Satoh, Tatsuo Shimosawa, Koji Shinozaki, Tomoaki Tomiya, Yukiko Inoue, Takako Nishikawa, Natsuko Ohtomo, Yasushi Tanoue, Hiromitsu Yokota, Takatoshi Koyama, Kazuhiro Ishimaru, Yasuo Okamoto, Yoh Takuwa, Kazuhiko Koike, Yutaka Yatomi – 13 April 2012 – Sinusoidal vasoconstriction, in which hepatic stellate cells operate as contractile machinery, has been suggested to play a pivotal role in the pathophysiology of portal hypertension.
Cardiovascular phenotype of nonalcoholic fatty liver disease: Hanging the paradigm about the role of distant toxic fat accumulation on vascular disease
Silvia Sookoian, Gustavo O. Castaño, Carlos J. Pirola – 13 April 2012
Hydrogen‐rich water prevents progression of nonalcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice
Daisuke Kawai, Akinobu Takaki, Atsuko Nakatsuka, Jun Wada, Naofumi Tamaki, Tetsuya Yasunaka, Kazuko Koike, Ryuichiro Tsuzaki, Kazuyuki Matsumoto, Yasuhiro Miyake, Hidenori Shiraha, Manabu Morita, Hirofumi Makino, Kazuhide Yamamoto – 13 April 2012 – Oxidative stress is a strong contributor to the progression from simple fatty liver to nonalcoholic steatohepatitis (NASH). Molecular hydrogen is an effective antioxidant that reduces cytotoxic reactive oxygen species.
Race‐ and gender‐related variation in natural killer p46 expression associated with differential anti‐hepatitis c virus immunity
Lucy Golden‐Mason, Amy E.L. Stone, Kiran M. Bambha, Linling Cheng, Hugo R. Rosen – 13 April 2012 – Major racial and gender differences have been documented in the natural history and treatment responses of chronic hepatitis C virus (HCV) infection; however, distinct mechanisms have remained enigmatic. We hypothesized that racial‐ and gender‐related differences in natural killer (NK) cell populations may explain altered natural history and treatment responses.