Hypoxia inducible factor 2 alpha inhibits hepatocellular carcinoma growth through the transcription factor dimerization partner 3/ E2F transcription factor 1–dependent apoptotic pathway

Hai‐Xiang Sun, Yang Xu, Xin‐Rong Yang, Wei‐Min Wang, Haibo Bai, Ruo‐Yu Shi, Suresh K. Nayar, Ranjan P. Devbhandari, Yi‐zhou He, Qingfeng Zhu, Yun‐Fan Sun, Bo Hu, Mehtab Khan, Robert A. Anders, Jia Fan – 5 December 2012 – Hypoxia inducible factors (HIFs) are activated in many tumors and show either promoter or suppressor activity, depending on tumor cell biology and background. However, the role of HIF member HIF‐2α remains unclear in hepatocellular carcinoma (HCC).

Bile salt export pump is dysregulated with altered farnesoid X receptor isoform expression in patients with hepatocellular carcinoma

Yuan Chen, Xiulong Song, Leila Valanejad, Alexander Vasilenko, Vijay More, Xi Qiu, Weikang Chen, Yurong Lai, Angela Slitt, Matthew Stoner, Bingfang Yan, Ruitang Deng – 5 December 2012 – As a canalicular bile acid effluxer, the bile salt export pump (BSEP) plays a vital role in maintaining bile acid homeostasis. BSEP deficiency leads to severe cholestasis and hepatocellular carcinoma (HCC) in young children. Regardless of the etiology, chronic inflammation is the common pathological process for HCC development.

Hepatocyte nuclear factor 1β is a novel prognostic marker independent of the milan criteria in transplantable hepatocellular carcinoma: A retrospective analysis based on tissue microarrays

Ju Hyun Shim, Han Chu Lee, Seungbong Han, Hyo Jeong Kang, Eunsil Yu, Sung‐Gyu Lee – 2 December 2012 – We retrospectively investigated the prognostic value of hepatocyte nuclear factor 1 (HNF1) proteins in 159 liver transplant patients with hepatocellular carcinoma (HCC), including 36 (22.6%) exceeding the Milan criteria. The expression of alpha‐fetoprotein (AFP), HNF1α, and HNF1β was examined with immunohistochemistry on duplicate tissue microarray slides containing HCC tumor explants.

Early and Long‐Term Results of Routine Microsurgical Biliary Reconstruction in Living Donor Liver Transplantation

Tsan‐Shiun Lin, Chao‐Long Chen, Allan M. Concejero, Anthony Q. Yap, Yu‐Hung Lin, Chun‐Yi Liu, Yuan‐Cheng Chiang, Chih‐Chi Wang, Shih‐Ho Wang, Chih‐Che Lin, Chee‐Chien Yong, Yu‐Fan Cheng – 29 November 2012 – We describe our early and long‐term experience with routine biliary reconstruction via a microsurgical technique in living donor liver transplantation (LDLT). One hundred seventy‐seven grafts (including 3 dual grafts) were primarily transplanted into 174 recipients. The minimum follow‐up was 44 months.

Liver‐specific p38α deficiency causes reduced cell growth and cytokinesis failure during chronic biliary cirrhosis in mice

Ana M. Tormos, Alessandro Arduini, Raquel Talens‐Visconti, Ivan del Barco Barrantes, Angel R. Nebreda, Juan Sastre – 29 November 2012 – p38α mitogen‐activated protein kinases (MAPK) may be essential in the up‐regulation of proinflammatory cytokines and can be activated by transforming growth factor β, tumor necrosis factor‐α, interleukin‐1β, and oxidative stress. p38 MAPK activation results in hepatocyte growth arrest, whereas increased proliferation has been considered a hallmark of p38α‐deficient cells.

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