Intraoperative transesophageal echocardiography reveals thrombotic stenosis of inferior vena cava during orthotopic liver transplantation
Jacob Aubuchon, Erin Maynard, Anand Lakshminarasimhachar, William Chapman, Ivan Kangrga – 21 November 2012
Selenium levels in patients with hepatitis C virus‐related chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma: A pilot study
Dominik Bettinger, Michael Schultheiss, Nadine Hennecke, Elisabeth Panther, Eva Knüppel, Hubert E. Blum, Robert Thimme, Hans Christian Spangenberg – 21 November 2012
Inhibition of hedgehog signaling attenuates carcinogenesis in vitro and increases necrosis of cholangiocellular carcinoma
Mona El Khatib, Anna Kalnytska, Vindhya Palagani, Uta Kossatz, Michael P. Manns, Nisar P. Malek, Ludwig Wilkens, Ruben R. Plentz – 21 November 2012 – The Hedgehog signaling pathway plays a pivotal role during embryonic development, stem cell maintenance, and wound healing. Hedgehog signaling also is deregulated in many cancers. However, the role of this signaling pathway in the carcinogenesis of cholangiocarcinoma (CCC) is still unknown.
Bayesian prediction for liver fibrosis staging: Combined use of elastography and serum fibrosis markers
Utaroh Motosugi, Tomoaki Ichikawa, Tsutomu Araki, Masanori Matsuda, Hideki Fujii, Nobuyuki Enomoto – 21 November 2012
Farnesoid X receptor inhibits gankyrin in mouse livers and prevents development of liver cancer
Yanjun Jiang, Polina Iakova, Jingling Jin, Emily Sullivan, Vladislav Sharin, Il‐Hwa Hong, Sayee Anakk, Angela Mayor, Gretchen Darlington, Milton Finegold, David Moore, Nikolai A. Timchenko – 21 November 2012 – One of the early events in the development of liver cancer is a neutralization of tumor suppressor proteins Rb, p53, hepatocyte nuclear factor 4α (HNF4α), and CCAAT/enhancer binding protein (C/EBP) α. The elimination of these proteins is mediated by a small subunit of proteasome, gankyrin, which is activated by cancer.
Late‐breaking Abstracts
19 November 2012
Association between plasma cyclic guanosine monophosphate levels and hemodynamic instability during liver transplantation
Dmitri Bezinover, Zakiyah Kadry, Tadahiro Uemura, Michael Sharghi, Andrea M. Mastro, Donna M. Sosnoski, Priti Dalal, Piotr K. Janicki – 16 November 2012 – The activation of cyclic guanosine monophosphate (cGMP) production in patients with end‐stage liver disease (ESLD) has been associated with hemodynamic instability during orthotopic liver transplantation (OLT). The aim of this prospective, observational study was to investigate the involvement of cGMP in the mediation of profound hypotension during liver graft reperfusion.
Innovative approach using an intragastric balloon for weight loss in a morbidly obese patient undergoing liver transplantation
Narendra S. Choudhary, Sanjiv Saigal, Neeraj Saraf, Rajesh Puri, Arvinder Soin – 14 November 2012
Transposition of the hepatic artery as a salvage procedure for an aortic pseudoaneurysm after liver transplantation
Anne Mossdorf, Tom Ulmer, Sebastian Kalverkamp, Ulf Neumann, Christoph Heidenhain – 14 November 2012
Power of metabolomics in diagnosis and biomarker discovery of hepatocellular carcinoma
Xijun Wang, Aihua Zhang, Hui Sun – 13 November 2012 – Hepatocellular carcinoma (HCC) is the commonest primary hepatic malignancy and the third most common cause of cancer‐related death worldwide. Incidence remains highest in the developing world and is steadily increasing across the developed world. Current diagnostic modalities, of ultrasound and α‐fetoprotein, are expensive and lack sensitivity in tumor detection. Because of its asymptomatic nature, HCC is usually diagnosed at late and advanced stages, for which there are no effective therapies.