Efficient replication of primary or culture hepatitis C virus isolates in human liver slices: A relevant ex vivo model of liver infection
Sylvie Lagaye, Hong Shen, Bertrand Saunier, Michelina Nascimbeni, Jesintha Gaston, Pierre Bourdoncle, Laurent Hannoun, Pierre‐Philippe Massault, Anaïs Vallet‐Pichard, Vincent Mallet, Stanislas Pol – 27 March 2012 – The development of human cultured hepatitis C virus (HCV) replication‐permissive hepatocarcinoma cell lines has provided important new virological tools to study the mechanisms of HCV infection; however, this experimental model remains distantly related to physiological and pathological conditions.