Smoking increases recurrent viral hepatitis after liver transplantation

Mamatha Bhat, Marc Deschenes, Xianming Tan, Myriam Martel, Venkataramana Bhat, Philip Wong, Peter Metrakos, Peter Ghali – 30 March 2012 – Smoking is a common behavior among transplant candidates. The aim of this study was to evaluate the effects of smoking on a range of complications after liver transplantation. We reviewed data about patient demographics and various complications after liver transplantation that were recorded in the McGill University Health Centre liver transplant database over a 14‐year period. χ2 and multivariate analyses were performed.

Prevalence and clinical outcomes of the 46/1 haplotype, Janus kinase 2 mutations, and ten‐eleven translocation 2 mutations in budd‐chiari syndrome and their impact on thrombotic complications post Liver Transplantation

Rachel H. Westbrook, Nicholas C. Lea, Azim M. Mohamedali, Alexander E. Smith, David W. Orr, Lara N. Roberts, Nigel D. Heaton, Julia A. Wendon, John G. O'Grady, Michael A. Heneghan, Ghulam J. Mufti – 30 March 2012 – Latent myeloproliferative disorders (MPDs) can be identified by Janus kinase 2 (JAK2) mutations in patients with idiopathic Budd‐Chiari syndrome (BCS). The incidence and clinical outcomes of JAK2 mutations, novel ten‐eleven translocation 2 (TET2) mutations, and the 46/1 haplotype in BCS are unknown for liver transplantation (LT).

Higher dietary fructose is associated with impaired hepatic adenosine triphosphate homeostasis in obese individuals with type 2 diabetes

Manal F. Abdelmalek, Mariana Lazo, Alena Horska, Susanne Bonekamp, Edward W. Lipkin, Ashok Balasubramanyam, John P. Bantle, Richard J. Johnson, Anna Mae Diehl, Jeanne M. Clark, and the Fatty Liver Subgroup of the Look AHEAD Research Group – 29 March 2012 – Fructose consumption predicts increased hepatic fibrosis in those with nonalcoholic fatty liver disease (NAFLD). Because of its ability to lower hepatic adenosine triphosphate (ATP) levels, habitual fructose consumption could result in more hepatic ATP depletion and impaired ATP recovery.

Recipient survival and graft survival are not diminished by simultaneous liver‐kidney transplantation: An analysis of the united network for organ sharing database

Eric F. Martin, Jonathan Huang, Qun Xiang, John P. Klein, Jasmohan Bajaj, Kia Saeian – 29 March 2012 – Recipients of solitary liver and kidney transplants are living longer, and this increases their risk of long‐term complications such as recurrent hepatitis C virus (HCV) and drug‐induced nephrotoxicity. These complications may require retransplantation. Since the adoption of the Model for End‐Stage Liver Disease, the number of simultaneous liver‐kidney transplantation (SLK) procedures has increased. However, there are no standardized criteria for organ allocation to SLK candidates.

Donor information for living donor liver transplantation: Where can comprehensive information be found?

Emmanuel Melloul, Dimitri Aristotle Raptis, Christian Eugen Oberkofler, Philipp Dutkowski, Mickael Lesurtel, Pierre‐Alain Clavien – 29 March 2012 – Recently published data show that a large number of candidates for living donor liver transplantation (LDLT) actively look for additional information on the Internet because today it represents the main source of information for many of them. However, little is known about the quality of the information on LDLT available on the Internet.

Impact of the donor body mass index on the survival of pediatric liver transplant recipients and Post‐transplant obesity

Emily Rothbaum Perito, Sue Rhee, Dave Glidden, John Paul Roberts, Philip Rosenthal – 29 March 2012 – In adult liver transplant recipients, the donor body mass index (dBMI) is associated with posttransplant obesity but not with graft or patient survival. Because of the obesity epidemic in the United States and the already limited supply of liver donors, clarifying whether the dBMI affects pediatric outcomes is important. United Network for Organ Sharing data for pediatric liver transplants in the United States (1990‐2010) were evaluated.

Long‐term outcomes of stereotactic body radiation therapy in the treatment of hepatocellular cancer as a bridge to transplantation

John K. O'Connor, James Trotter, Gary L. Davis, Jane Dempster, Goran B. Klintmalm, Robert M. Goldstein – 29 March 2012 – Hepatocellular carcinoma (HCC) is potentially curable with hepatic resection or transplantation. Few patients are eligible for resection, and many face a long wait for donor organ availability for liver transplantation. Here we report the safety and efficacy of stereotactic body radiation therapy (SBRT), the explant pathology findings and survival of patients treated with SBRT as a bridge to transplantation for HCC.

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