Outcomes of liver transplantation for patients with alagille syndrome: The studies of pediatric liver transplantation experience

Binita M. Kamath, Wanrong Yin, Heather Miller, Ravinder Anand, Elizabeth B. Rand, Estella Alonso, John Bucuvalas, for Studies of Pediatric Liver Transplantation – 27 March 2012 – Alagille syndrome (ALGS) is a multisystem disorder that manifests as childhood cholestasis. Reports of liver transplantation (LT) for patients with ALGS have come largely from single centers, which have reported survival rates of 57% to 79%. The aim of this study was to determine LT outcomes for patients with ALGS.

Increasing the recipient benefit/donor risk ratio by lowering the graft size requirement for living donor liver transplantation

See Ching Chan, Sheung Tat Fan, Kenneth S. H. Chok, William W. Sharr, Wing Chiu Dai, James Y. Y. Fung, Kwok Yin Chan, Dharmesh J. Balsarkar, Chung Mau Lo – 27 March 2012 – In living donor liver transplantation (LDLT), a right liver graft is larger than a left liver graft and hence leads to better recipient survival. However, in comparison with donor left hepatectomy, donor right hepatectomy carries a higher donor risk.

Association of AKI With mortality and complications in hospitalized patients with cirrhosis

Justin M. Belcher, Guadalupe Garcia‐Tsao, Arun J. Sanyal, Harjit Bhogal, Joseph K. Lim, Naheed Ansari, Steven G. Coca, Chirag R. Parikh, for the TRIBE‐AKI Consortium – 27 March 2012 – Acute kidney injury (AKI) is a common and devastating complication in patients with cirrhosis. However, the definitions of AKI employed in studies involving patients with cirrhosis have not been standardized, lack sensitivity, and are often limited to narrow clinical settings.

Efficient replication of primary or culture hepatitis C virus isolates in human liver slices: A relevant ex vivo model of liver infection

Sylvie Lagaye, Hong Shen, Bertrand Saunier, Michelina Nascimbeni, Jesintha Gaston, Pierre Bourdoncle, Laurent Hannoun, Pierre‐Philippe Massault, Anaïs Vallet‐Pichard, Vincent Mallet, Stanislas Pol – 27 March 2012 – The development of human cultured hepatitis C virus (HCV) replication‐permissive hepatocarcinoma cell lines has provided important new virological tools to study the mechanisms of HCV infection; however, this experimental model remains distantly related to physiological and pathological conditions.

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