Michael W. Fried, Donald M. Jensen – 29 November 2012

Matthew Zhang, Shinya Ueki, Shoko Kimura, Osamu Yoshida, Antonino Castellaneta, Kikumi S. Ozaki, Anthony J. Demetris, Mark Ross, Yoram Vodovotz, Angus W. Thomson, Donna B. Stolz, David A. Geller, Noriko Murase – 26 November 2012 – Dendritic cells (DCs) induce and regulate both innate and adaptive immune responses; however, their in vivo functional importance in hepatic ischemia/reperfusion (IR) injury is perplexing. We hypothesized that liver‐resident DC and locally recruited blood‐borne DC might have distinctive roles in hepatic IR injury.

Cindy Kunne, Alexandra Acco, Simon Hohenester, Suzanne Duijst, Dirk R. de Waart, Alaleh Zamanbin, Ronald P.J. Oude Elferink – 26 November 2012 – The difference in bile salt (BS) composition between rodents and humans is mainly caused by formation of muricholate in rodents as well as by efficient rehydroxylation of deoxycholic acid. The aim of this study was to characterize bile formation in a mouse model (Hrn mice) with hepatic disruption of the cytochrome p450 (CYP) oxidoreductase gene, encoding the single electron donor for all CYPs.

Richy C.Y. Chen, Phornnop Naiyanetr, Shang‐An Shu, Jinjun Wang, Guo‐Xiang Yang, Thomas P. Kenny, Kathryn C. Guggenheim, Jeffrey D. Butler, Christopher Bowlus, Mi‐Hua Tao, Mark J. Kurth, Aftab A. Ansari, Marshall Kaplan, Ross L. Coppel, Ana Lleo, M. Eric Gershwin, Patrick S.C. Leung – 26 November 2012 – Antimitochondrial antibodies (AMAs) directed against the lipoyl domain of the E2 subunit of pyruvate dehydrogenase (PDC‐E2) are detected in 95% of patients with primary biliary cirrhosis (PBC) and are present before the onset of clinical disease.

Vincenzo La Mura, Marcos Pasarín, Cintia Z. Meireles, Rosa Miquel, Aina Rodríguez‐Vilarrupla, Diana Hide, Jorge Gracia‐Sancho, Juan Carlos García‐Pagán, Jaime Bosch, Juan G. Abraldes – 26 November 2012 – Endothelial dysfunction drives vascular derangement and organ failure associated with sepsis. However, the consequences of sepsis on liver sinusoidal endothelial function are largely unknown. Statins might improve microvascular dysfunction in sepsis. The present study explores liver vascular abnormalities and the effects of statins in a rat model of endotoxemia.

Tsunekazu Oikawa, Akihide Kamiya, Mikio Zeniya, Hiromi Chikada, Ahn Dong Hyuck, Yuji Yamazaki, Eliane Wauthier, Hisao Tajiri, Lance D. Miller, Xin Wei Wang, Lola M. Reid, Hiromitsu Nakauchi – 23 November 2012 – Liver cancers, including hepatocellular carcinomas (HCCs), cholangiocarcinomas (CCs), and fibrolamellar HCCs (FL‐HCCs) are among the most common cancers worldwide and are associated with a poor prognosis. Investigations of genes important in liver cancers have focused on Sal‐like protein 4 (SALL4), a member of a family of zinc finger transcription factors.

Song Zhang, Ruifang Liang, Wei Luo, Chang Liu, Xiaoli Wu, Yanan Gao, Jianlei Hao, Guangchao Cao, Xi Chen, Jun Wei, Siyuan Xia, Zheng Li, Ti Wen, Yunyun Wu, Xinglong Zhou, Puyue Wang, Liqing Zhao, Zhengzhou Wu, Sidong Xiong, Xiaoming Gao, Xiang Gao, Yongyan Chen, Qing Ge, Zhigang Tian, Zhinan Yin – 23 November 2012 – Interleukin (IL)‐27, a newly discovered IL‐12 family cytokine, is composed of p28 and EBI3. In this study, CD11c‐p28f/f conditional knockout mice were generated to delete p28 specifically in dendritic cells (DCs).

Emerson Y. Chen, Karl Baum, William Collins, Arthur Löve, Michael Merz, Sigurdur Olafsson, Einar S. Björnsson, William M. Lee – 23 November 2012 – The patient presented below gives us the opportunity to discuss challenges in the diagnosis of drug‐induced liver injury in an era of increasing awareness of hepatitis E. (HEPATOLOGY 2012;)

Mark A. Barnes, Megan R. McMullen, Sanjoy Roychowdhury, Sorana G. Pisano, Xiuli Liu, Abram B. Stavitsky, Richard Bucala, Laura E. Nagy – 23 November 2012 – Macrophage migration inhibitory factor (MIF), a multipotent protein that exhibits both cytokine and chemotactic properties, is expressed by many cell types, including hepatocytes and nonparenchymal cells. We hypothesized that MIF is a key contributor to liver injury after ethanol exposure.

Naoki Kumashiro, Toru Yoshimura, Jennifer L. Cantley, Sachin K. Majumdar, Fitsum Guebre‐Egziabher, Romy Kursawe, Daniel F. Vatner, Ioana Fat, Mario Kahn, Derek M. Erion, Xian‐Man Zhang, Dongyan Zhang, Vara Prasad Manchem, Sanjay Bhanot, Glenn S. Gerhard, Kitt F. Petersen, Gary W. Cline, Varman T. Samuel, Gerald I. Shulman – 23 November 2012 – Genome‐wide array studies have associated the patatin‐like phospholipase domain‐containing 3 (PNPLA3) gene polymorphisms with hepatic steatosis.